Ascorbylpalmitat | 1184913-60-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ascorbylpalmitat
• 英文别名: L-Ascorbyl palmitate；[2-(3,4-dihydroxy-5-oxo-2H-furan-2-yl)-2-hydroxyethyl] hexadecanoate
• CAS: 1184913-60-7
• 化学式: C₂₂H₃₈O₇
• 分子量: 414.54
• InChiKey: QAQJMLQRFWZOBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  29
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Ascorbylpalmitat 在 calcium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 以99 %的产率得到palmitoyl ascorbate calcium salt
  参考文献：
  名称：

  [EN] CURABLE COMPOSITION PREPARATION KIT, CURABLE COMPOSITION, CURED ARTICLE, AND DENTAL MATERIAL
  [FR] KIT POUR PRÉPARATION DE COMPOSITION DURCISSABLE, COMPOSITION DURCISSABLE, OBJET DURCI, ET PRODUIT DENTAIRE
  [JA] 硬化性組成物調製用キット、硬化性組成物、硬化物及び歯科材料

  摘要：

  第１モノマーを含む第１剤と、第２モノマーを含む第２剤と、を備え、第１剤及び第２剤の少なくとも一方は、アスコルビン酸類と、アルコキシシリル基又はヒドロキシシリル基の少なくとも一方を含む化合物Ａと、をそれぞれ独立に含む硬化性組成物調製用キット。

  公开号：

  WO2024029507A1
• 作为产物：
  描述：

  棕榈酸 、 异抗坏血酸 在 Staphylococcus xylosus lipase immobilized onto silica aerogel 作用下， 以 乙腈 、 叔丁醇 为溶剂， 反应 72.0h， 生成 Ascorbylpalmitat
  参考文献：
  名称：

  Lipophilization of Ascorbic Acid: A Monolayer Study and Biological and Antileishmanial Activities

  摘要：

  Ascorbyl lipophilic derivatives (Asc-C2 to Asc-C(18:1)) were synthesized in a good yield using lipase from Staphylococcus xylosus produced in our laboratory and immobilized onto silica aerogel. Results showed that esterification had little effect on radical-scavenging capacity of purified ascorbyl esters using DPPH assay in ethanol. However, long chain fatty acid esters displayed higher protection of target lipids from oxidation. Moreover, compared to ascorbic acid, synthesized derivatives exhibited an antibacterial effect. Furthermore, ascorbyl derivatives were evaluated, for the first time, for their antileishmanial effects against visceral (Leishmania infantum) and cutaneous parasites (Leishmania major). Among all the tested compounds, only Asc-C10, Asc-C12, and Asc-C(18:1) exhibited antileishmanial activities. The interaction of ascorbyl esters with a phospholipid monolayer showed that only medium and unsaturated long chain (Asc-C10 to Asc-C(18:1)) derivative esters were found to interact efficiently with mimetic membrane of leishmania. These properties would make ascorbyl derivatives good candidates to be used in cosmetic and pharmaceutical lipophilic formulations.

  DOI：

  10.1021/jf5029398
• 作为试剂：
  描述：

  Zeaxanthin-diacetat 在 sodium iodide 、 sodium bromate 、 sodium disulfite 、 没食子酸丙酯 、 Ascorbylpalmitat 、 sodium sulfite 作用下， 以 氯仿 、 水 为溶剂， 反应 6.17h， 生成 Astaxanthin-diacetat 、 3-acetoxy-3'-hydroxycanthaxanthin
  参考文献：
  名称：

  Method for producing esterified astaxanthin from esterified zeaxanthin

  摘要：

  本文描述了一种从玉米黄素制备虾青素酯的方法，该方法通过将玉米黄素与酰化试剂酰化，然后将酯化的玉米黄素与氧化剂接触，以产生酯化的虾青素。当用于鲑鱼色素时，虾青素酯比游离虾青素更稳定，显示出更好的生物利用度。

  公开号：

  US20040158097A1

文献信息

• Cyclopentanone derivatives, method of synthesis and uses thereof
  申请人：Neuropharma S.A.

  公开号：EP1939192A1

  公开（公告）日：2008-07-02

  The present invention relates to cyclopentanone derivatives of formula (I), their method of synthesis and uses thereof. Concretely, the compounds disclosed have proved to be inhibitors of glycogen synthase kinase 3β, GSK-3 β, which is known to be involved in different disease and conditions, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition.

  本发明涉及公式（I）的环戊酮衍生物，其合成方法及用途。具体来说，所披露的化合物已被证明是糖原合成酶激酶3β（GSK-3β）的抑制剂，GSK-3β已知参与不同疾病和病况，如阿尔茨海默病或非胰岛素依赖型糖尿病。本发明还涉及包含这些化合物的药物组合物。此外，本发明旨在将这些化合物用于制造治疗和/或预防GSK-3介导的疾病或病况的药物。
• NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENTRAPPED AGENTS
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：US20170000888A1

  公开（公告）日：2017-01-05

  Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

  描述了包括凝胶剂的自组装凝胶组合物，例如，一种酶可切割的凝胶剂，例如，具有分子量不超过2500的凝胶剂。这些自组装凝胶组合物可以包裹一个或多个药剂。还描述了制备这些自组装凝胶组合物的方法，以及使用这些自组装凝胶组合物进行药物传递的方法。
• COMPOSITION WITH A POLYMER AND AN OXIDATION-CATALYST
  申请人：Gijsman Pieter

  公开号：US20110034637A1

  公开（公告）日：2011-02-10

  The present invention relates to a polymer composition with an increased rate of oxygen-uptake by the presence of a co-catalyst and an oxidation catalyst. The oxidation catalyst has the following structure with R 1 : a group selected independently from one another from the groups consisting of H, an optionally substituted C 1 -C 20 alkyl group, an optionally substituted C 6 -C 20 aryl group, an optionally substituted C 7 -C 20 alkylaryl group, and an optionally substituted C 7 -C 20 arylalkyl group; R 2 : OR, SR, NRR′, R, O − M + ; in which R, R′: a group selected independently from one another from the groups consisting of H, an optionally substituted C 1 -C 20 alkyl group, an optionally substituted C 6 -C 20 aryl group, an optionally substituted C 7 -C 20 alkylaryl group, and an optionally substituted C 7 -C 20 arylalkyl group; M + : an alkaline metal cation or earth alkaline metal cation, or an ammonium ion; R 3 : SR, NRR′, R, O − M + ; in which R, R′: a group selected independently from one another from the groups consisting of H, an optionally substituted C 1 -C 20 alkyl group, an optionally substituted C 6 -C 2 aryl group, an optionally substituted C 7 -C 20 alkylaryl group, and an optionally substituted C 7 -C 20 arylalkyl group; M + : an alkaline metal cation or earth alkaline metal cation, or an ammonium ion. R 1 -R 3 may be joined together to form a cyclic structure. Or R 3 : OR in which R: a group selected independently from one another from the groups consisting of H, an optionally substituted C 1 -C 20 alkyl group, an optionally substituted C 6 -C 20 aryl group, an optionally substituted C 7 -C 20 alkylaryl group, and an optionally substituted C 7 -C 20 arylalkyl group and at least one of R 1 , R 2 and R 3 are joined together and form a cyclic structure containing less than 5 carbon atoms. The co-catalyst is at least one of an alkaline metal salt, earth alkaline metal salt or an ammonium salt. The invention further relates to a process to increase the rate of oxygen-uptake by a polymer composition. The invention also relates to a process to increase the oxo-biodegradability of a polymer composition and to the use of such a composition for the preparation of a product having a controlled lifetime. The invention further relates to a process to increase the rate of oxygen-scavenging in a composition containing a carbon-containing polymer, the composition obtained by this method and its use in the preparation of an oxygen-scavenging product. The present invention further relates to objects containing an oxygen scavenging layer containing such a composition.

  本发明涉及一种聚合物组合物，通过共催化剂和氧化催化剂的存在提高氧气吸收速率。氧化催化剂具有以下结构，其中R1：从H、可选取代的C1-C20烷基、可选取代的C6-C20芳基、可选取代的C7-C20烷基芳基和可选取代的C7-C20芳基烷基组成的各组中独立选择的一组；R2：OR、SR、NRR'、R、O-M+，其中R、R'：从H、可选取代的C1-C20烷基、可选取代的C6-C20芳基、可选取代的C7-C20烷基芳基和可选取代的C7-C20芳基烷基组成的各组中独立选择的一组；M+：碱金属阳离子或地球碱金属阳离子或铵离子；R3：SR、NRR'、R、O-M+，其中R、R'：从H、可选取代的C1-C20烷基、可选取代的C6-C20芳基、可选取代的C7-C20烷基芳基和可选取代的C7-C20芳基烷基组成的各组中独立选择的一组；M+：碱金属阳离子或地球碱金属阳离子或铵离子。 R1-R3可以结合在一起形成环状结构。或R3：OR，其中R：从H、可选取代的C1-C20烷基、可选取代的C6-C20芳基、可选取代的C7-C20烷基芳基和可选取代的C7-C20芳基烷基组成的各组中独立选择的一组，且R1、R2和R3中至少有一个结合在一起形成含有少于5个碳原子的环状结构。共催化剂至少为碱金属盐、地球碱金属盐或铵盐之一。本发明还涉及一种提高聚合物组合物氧气吸收速率的方法。本发明还涉及一种提高聚合物组合物氧化生物降解性的方法，以及使用这种组合物制备具有可控寿命的产品的方法。本发明还涉及一种提高含碳聚合物组合物氧气清除速率的方法，以及通过此方法获得的组合物及其在制备氧气清除产品中的使用。本发明还涉及包含含有这种组合物的氧气清除层的物品。
• Nanostructured gels capable of controlled release of encapsulated agents
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：US10675351B2

  公开（公告）日：2020-06-09

  Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

  本文描述了自组装凝胶组合物，其中包括凝胶剂，如分子量为 2500 或更小的可酶解凝胶剂。自组装凝胶组合物可以封装一种或多种药剂。还描述了自组装凝胶组合物的制造方法和使用自组装凝胶组合物的给药方法。
• DIHYDROXY ENOL COMPOUNDS USED IN CHEMICAL MECHANICAL POLISHING COMPOSITIONS HAVING METAL ION OXIDIZERS
  申请人：Siddiqui Junaid Ahmed

  公开号：US20090308836A1

  公开（公告）日：2009-12-17

  A chemical mechanical polishing composition contains 1) water, 2) optionally an abrasive material, 3) an oxidizer, preferably a per-type oxidizer, 4) a small amount of soluble metal-ion oxidizer/polishing accelerator, a metal-ion polishing accelerator bound to particles such as to abrasive particles, or both; and 5) at least one of the group selected from a) a small amount of a chelator, b) a small amount of a dihydroxy enolic compound, and c) a small amount of an organic accelerator. Ascorbic acid in an amount less than 800 ppm, preferably between about 100 ppm and 500 ppm, is the preferred dihydroxy enolic compound. The polishing compositions and processes are useful for substantially all metals and metallic compounds found in integrated circuits, but is particularly useful for tungsten. The present invention also pertains to surface-modified colloidal abrasive polishing compositions and associated methods of using these compositions, particularly for chemical mechanical planarization, wherein the slurry comprises low levels of chelating free radical quenchers, non-chelating free radical quenchers, or both.