(+)-1,2,3,6-tetrahydro-1,4-dimethylazulene

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: (+)-1,2,3,6-tetrahydro-1,4-dimethylazulene
• 英文别名: (+)-1,2,3,6-Tetrahydro-1,4-dimethylazulene；1,4-dimethyl-1,2,3,6-tetrahydroazulene
• 化学式: C₁₂H₁₆
• 分子量: 160.259
• InChiKey: QOXYDBYDOMCGHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  在 Amberlyst(R) 15 作用下， 以 正己烷 为溶剂， 反应 2.0h， 生成 (-)-2,3,3a,4,5,6-hexahydro-1,4-dimethylazulen-4-ol 、 (+)-1,2,3,6-tetrahydro-1,4-dimethylazulene
  参考文献：
  名称：

  Sesquiterpenoids and norsesquiterpenoids from three liverworts

  摘要：

  Six new sesquiterpenoids and two new norsesquiterpenoids were isolated from the essential oils of three liverworts. The isolated compounds include (+)-eudesma-4,11-dien-8o alpha-ol from the liverwort Diplophyllum albicans, (-)-4 beta,5 beta-diacetoxygymnomitr-3(15)-ene, (+)-5 beta-acetoxygymnomitr-3(15)-ene, (-)-15-acetoxygymnomitr-3-ene, (-)-3 beta,15 beta-epoxy-4 beta-acetoxygymnomitrane, and (-)-3o alpha,15 alpha-epoxy-4 beta-acetoxygymnomitrane from Marsupella emarginata, and (+)-1,2,3,6-tetrahydro-1,4-dimethylazulene and (-)-2,3,3a,4,5,6-hexahydro-1,4-dimethylazulen-4-ol from Barbilophozia floerkei. These compounds were isolated by a combination of different chromatographic techniques, and their structures were determined by extensive spectroscopic studies (MS, H-1, C-13, and 2D NMR) and chemical transformations using enantio selective GC. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.06.036

文献信息

• Sesquiterpenoids and norsesquiterpenoids from three liverworts
  作者：Adewale M. Adio、Wilfried A. König

  DOI：10.1016/j.tetasy.2007.06.036

  日期：2007.7

  Six new sesquiterpenoids and two new norsesquiterpenoids were isolated from the essential oils of three liverworts. The isolated compounds include (+)-eudesma-4,11-dien-8o alpha-ol from the liverwort Diplophyllum albicans, (-)-4 beta,5 beta-diacetoxygymnomitr-3(15)-ene, (+)-5 beta-acetoxygymnomitr-3(15)-ene, (-)-15-acetoxygymnomitr-3-ene, (-)-3 beta,15 beta-epoxy-4 beta-acetoxygymnomitrane, and (-)-3o alpha,15 alpha-epoxy-4 beta-acetoxygymnomitrane from Marsupella emarginata, and (+)-1,2,3,6-tetrahydro-1,4-dimethylazulene and (-)-2,3,3a,4,5,6-hexahydro-1,4-dimethylazulen-4-ol from Barbilophozia floerkei. These compounds were isolated by a combination of different chromatographic techniques, and their structures were determined by extensive spectroscopic studies (MS, H-1, C-13, and 2D NMR) and chemical transformations using enantio selective GC. (c) 2007 Elsevier Ltd. All rights reserved.