5,7,4′-trihydroxy-3′-methoxy-6,8-dimethylflavanone | 95273-00-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5,7,4′-trihydroxy-3′-methoxy-6,8-dimethylflavanone
• 英文别名: 6,8-dimethyl-3’-methoxy-4’,5,7-trihydroxyflavanone；5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6,8-dimethyl-chroman-4-one；5,7-Dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6,8-dimethyl-chroman-4-on；6,8-dimethyl-5,7,4'-trihydroxy-3'-methoxyflavanone；5,7,4'-Trihydroxy-3'-methoxy-6,8-di-C-methylflavanone；5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,8-dimethyl-2,3-dihydrochromen-4-one
• CAS: 95273-00-0
• 化学式: C₁₈H₁₈O₆
• 分子量: 330.337
• InChiKey: QVDZTDYQDZOHRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  二甲基均苯三酚 、 alkaline earth salt of/the/ methylsulfuric acid 在 三氯化铝 、 硝基苯 作用下， 生成 5,7,4′-trihydroxy-3′-methoxy-6,8-dimethylflavanone
  参考文献：
  名称：

  SYNTHETISCHE VERSUCHE MIT METHYL-TRIOXYBENZOL. MITTEILUNG I. SYNTHESE VON 2.6-DIMETHYLPOLYOXY-FLAVANONEN

  摘要：

  DOI：

  10.1246/bcsj.9.24

文献信息

• Pharmaceutical compositions containing compounds with a flavanone
  申请人：Inverni Della Beffa S.p.A.

  公开号：US04636569A1

  公开（公告）日：1987-01-13

  Compounds with a flavanone skeleton having the formula I ##STR1## in which R.sub.1 and R.sub.2, which may be the same or different, represent hydrogen, hydroxyl, methoxyl, thiomethyl, amino or substituted amino, are endowed with expectorant, mucolytic, mucopoietic, choleretic and hypolipaemia-producing activity.

  具有公式I的黄酮骨架化合物，其中R1和R2表示氢、羟基、甲氧基、硫代甲基、氨基或取代氨基，它们具有祛痰、液化痰液、刺激粘膜细胞增生、促进胆汁分泌和降低血脂的活性。
• Pharmaceutical compositions containing compounds with a flavanone skeleton and process for the preparation of said compounds
  申请人：INVERNI DELLA BEFFA S.P.A.

  公开号：EP0122053A2

  公开（公告）日：1984-10-17

  Compounds with a flavanone skeleton having the formula I in which R1 and R2, which may be the same or different, represent hydrogen, hydroxyl, methoxyl, thiomethyl, amino or substituted amino, are endowed with expectorant, mucolytic, mucopoietic, chloretic and hypolipaemia-producing activity.

  具有式 I 的黄烷酮骨架的化合物，其中 R1 和 R2（可以相同或不同）代表氢、羟基、甲氧基、硫甲基、氨基或取代氨基，具有祛痰、粘液溶解、粘液造血、软化胆囊和降血脂活性。
• Flavone/ flavanone derivatives for the systemic treatment and prophlaxis of uv-induced dermatoses
  申请人：——

  公开号：US20040038914A1

  公开（公告）日：2004-02-26

  The invention relates to the use of flavone/flavanone derivatives of general fortnula (I) for the production of medicaments for the systematic treatment and prophylaxis of UV-induced dermatoses, in particular polymorphic light dermatoses and the sub-types thereof and/or the undesired long-term consequences of UV-radiation, in particular light-aging. The invention further relates to the use of the compounds of general formula (I) for the systematic treatment and prophylaxis of the above UV-induced dermatoses.

  本发明涉及使用通式（I）的黄酮/黄烷酮衍生物生产药物，用于系统治疗和预防紫外线引起的皮肤病，特别是多形性光皮肤病及其亚型和/或紫外线辐射的长期不良后果，特别是光老化。本发明进一步涉及通式（I）化合物在系统治疗和预防上述紫外线引起的皮肤病方面的用途。
• FLAVON-/FLAVANON-DERIVATEN ZUR SYSTEMISCHEN BEHANDLUNG UND PROPHYLAXE VON UV-INDUZIERTEN DERMATOSEN
  申请人：Krutmann, Jean

  公开号：EP1294374A1

  公开（公告）日：2003-03-26
• AN ANTI-DIABETIC EXTRACT OF HONEYBUSH
  申请人：Zadec APS

  公开号：EP2120924A2

  公开（公告）日：2009-11-25