3,5,6,7,8-pentahydroxy-2-phenyl-4H-1-benzopyran-4-one | 727388-91-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3,5,6,7,8-pentahydroxy-2-phenyl-4H-1-benzopyran-4-one
• 英文别名: 3,5,6,7,8-pentahydroxy-flavone；3,5,6,7,8-pentahydroxy-2-phenyl-chromen-4-one；3,5,6,7,8-Pentahydroxy-2-phenyl-chromen-4-on；3,5,6,7,8-pentahydroxy-2-phenylchromen-4-one
• CAS: 727388-91-2
• 化学式: C₁₅H₁₀O₇
• 分子量: 302.24
• InChiKey: RNKSNQNKTRGJSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3,5,6,7,8-pentahydroxy-2-phenyl-4H-1-benzopyran-4-one 、 乙酸酐 在 吡啶 作用下， 生成 3,5,6,7,8-pentaacetoxy-2-phenyl-chromen-4-one
  参考文献：
  名称：

  Sastri; Seshadri, Proceedings - Indian Academy of Sciences, Section A, 1946, # 24, p. 243,252

  摘要：

  DOI：
• 作为产物：
  描述：

  2-hydroxy-3,4,5,6,ο-pentamethoxyacetophenone 在 sodium benzoate 、 氢碘酸 、 乙酸酐 作用下， 生成 3,5,6,7,8-pentahydroxy-2-phenyl-4H-1-benzopyran-4-one
  参考文献：
  名称：

  Seshadri; Venkateswarlu, Proceedings - Indian Academy of Sciences, Section A, 1946, # 23, p. 192,200

  摘要：

  DOI：

文献信息

• Nitric oxide donating derivatives for the treatment of cardiovascular disorders
  申请人：Tucker Joseph

  公开号：US20050080024A1

  公开（公告）日：2005-04-14

  Compounds comprising nitric oxide derivatives of stilbenes, polyphenols and flavonoids and methods of their use are provided for treating patients suffering from any of hypercholesterolemia, vascular oxidative stress and endothelial dysfunction.

  本发明提供了由stilbenes、多酚和类黄酮的亚硝酸盐衍生物组成的化合物，以及它们的使用方法，用于治疗患有高胆固醇血症、血管氧化应激和内皮功能障碍的患者。
• Sirtuin polymorphisms and methods of use thereof
  申请人：Laakso Markku

  公开号：US20080249103A1

  公开（公告）日：2008-10-09

  Provided herein are methods for diagnosis and prognosis using polymorphic variants of sirtuins. Such polymorphic may be used, for example, to identify subjects that would be responsive to treatment with a sirtuin modulating compound and/or subjects that are suffering from or susceptible to a disease mediated by a sirtuin. Also provided are methods for determining the predictive value of a sirtuin polymorphic variant, methods for evaluating sirtuin modulating compounds, and methods for determining appropriate dosage and/or treatment regimens for subjects having one or more sirtuin polymorphic variants. Screening methods for identifying sirtuin modulating compounds using polymorphic variants of a sirtuin are also provided.

  本文提供了使用sirtuins的多态性变体进行诊断和预后的方法。这种多态性可能被用来识别对sirtuin调节化合物治疗有响应的受试者，以及患有或易受sirtuin介导疾病影响的受试者。还提供了确定sirtuin多态性变体预测价值的方法，评估sirtuin调节化合物的方法，以及确定具有一个或多个sirtuin多态性变体的受试者的适当剂量和/或治疗方案的方法。还提供了使用sirtuin的多态性变体筛选识别sirtuin调节化合物的筛选方法。
• BIOMARKERS OF SIRTUIN ACTIVITY AND METHODS OF USE THEREOF
  申请人：Boss Olivier

  公开号：US20100215632A1

  公开（公告）日：2010-08-26

  Provided are methods for monitoring sirtuin modulation in a subject, for example, during therapeutic treatment with a sirtuin modulating compound. The methods involve determining the expression level of one or more sirtuin biomarkers in a biological sample from the subject. Also provided are methods for identifying compounds that modulate the activity of a sirtuin protein using one or more sirtuin biomarkers.

  提供了一种监测主体中sirtuin调节的方法，例如，在使用sirtuin调节化合物进行治疗期间。该方法涉及确定来自主体生物样本中一个或多个sirtuin生物标志物的表达水平。还提供了一种使用一个或多个sirtuin生物标志物识别调节sirtuin蛋白活性的化合物的方法。
• [EN] POLYPHENOL ANALOGS TO TREAT ISCHEMIA<br/>[FR] ANALOGUES DE POLYPHÉNOL POUR TRAITER UNE ISCHÉMIE
  申请人：LAPCHAK PAUL A

  公开号：WO2013025484A1

  公开（公告）日：2013-02-21

  The present invention provides methods of use of polyphenol compounds for treating, preventing, mitigating and delaying ischemia or a condition where ischemia occurs. In one embodiment, the method comprises providing a polyphenol analog; and administering the polyphenol analog to a subject to treat ischemia or a condition where ischemia occurs. Various embodiments of the present invention are useful for the treatment of patients having, or at risk for, any of (1) ischemic stroke, (2) hemorrhagic stroke, (3) cardiovascular disease, (4) ischemia related spinal cord injury, (5) ischemia in diabetic patients, or (6) embolic stroke.. For example, use of the polyphenol compounds can maintain glutathione levels in the patient.

  本发明提供了使用多酚化合物治疗、预防、缓解和延迟缺血或发生缺血状况的方法。在一个实施方式中，该方法包括提供一种多酚类似物；并将该多酚类似物给予受试者以治疗缺血或发生缺血状况。本发明的各种实施方式适用于治疗患有或有风险患有以下任何一种疾病的患者：（1）缺血性中风，（2）出血性中风，（3）心血管疾病，（4）与缺血有关的脊髓损伤，（5）糖尿病患者的缺血，或（6）栓塞性中风。例如，使用多酚化合物可以维持患者的谷胱甘肽水平。
• [EN] NEUROPROTECTIVE POLYPHENOL ANALOGS<br/>[FR] ANALOGUES DU POLYPHÉNOL NEUROPROTECTEURS
  申请人：SCHUBERT DAVID R

  公开号：WO2013025498A1

  公开（公告）日：2013-02-21

  The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and/or antioxidant properties. The neuroprotective polyphenol compounds are useful for promoting, enhancing and/or increasing neuron protection, growth and/or regeneration. The polyphenol compounds further find use for increasing and or maintaining intracellular glutathione (GSH) levels. The polyphenol compounds are also useful for treating, preventing, mitigating and/or delaying neurodegenerative conditions, including diabetes, Parkinson's disease, Huntington's disease, Alzheimer's disease, non-Alzherimer's dementias, multiple sclerosis, traumatic brain injury, spinal cord injury or ALS.

  本发明提供了神经保护多酚化合物，可以是嘌呤、黄芩素或绿原酸的合成类似物，这些化合物具有保持神经保护、抗炎、促进谷胱甘肽以及抗氧化性能。这些神经保护多酚化合物可用于促进、增强和/或增加神经元的保护、生长和/或再生。多酚化合物还可用于增加和/或维持细胞内谷胱甘肽（GSH）水平。多酚化合物还可用于治疗、预防、缓解和/或延缓神经退行性疾病，包括糖尿病、帕金森病、亨廷顿病、阿尔茨海默病、非阿尔茨海默病性痴呆、多发性硬化症、创伤性脑损伤、脊髓损伤或肌萎缩侧索硬化症（ALS）。