2-Methoxy-6-(1-methyl-2-oxo-propyl)-[1,4]benzoquinone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methoxy-6-(1-methyl-2-oxo-propyl)-[1,4]benzoquinone
• 英文别名: 2-Methoxy-6-(3-oxobutan-2-yl)cyclohexa-2,5-diene-1,4-dione
• 化学式: C₁₁H₁₂O₄
• 分子量: 208.214
• InChiKey: RYIGSNBSBGKNIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Methoxy-6-(1-methyl-2-oxo-propyl)-[1,4]benzoquinone 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 dihydromalbranicin
  参考文献：
  名称：

  A novel quinone antibiotic from Malbranchea cinnamomea TAIM 13T54.

  摘要：

  A novel quinone antibiotic named malbranicin was isolated from the culture filtrate and mycelium of Malbranchea cinnamomea TAIM 13T54, a thermophilic fungus. The antibiotic was elucidated to be 6-(1-acetylethyl)-2-methoxy-2, 5-cyclohexadiene-1, 4-dione by spectral analysis. Malbranicin exhibited antimicrobial and cytotoxic activities against Gram-positive bacteria and mammalian cell lines, respectively.

  DOI：

  10.7164/antibiotics.46.1819

文献信息

• A novel quinone antibiotic from Malbranchea cinnamomea TAIM 13T54.
  作者：YIN-MEI CHIUNG、TOMOYUKI FUJITA、MASAHIRA NAKAGAWA、HIROSHI NOZAKI、GUEH-YUH CHEN、ZUEI-CHING CHEN、MITSURU NAKAYAMA

  DOI：10.7164/antibiotics.46.1819

  日期：——

  A novel quinone antibiotic named malbranicin was isolated from the culture filtrate and mycelium of Malbranchea cinnamomea TAIM 13T54, a thermophilic fungus. The antibiotic was elucidated to be 6-(1-acetylethyl)-2-methoxy-2, 5-cyclohexadiene-1, 4-dione by spectral analysis. Malbranicin exhibited antimicrobial and cytotoxic activities against Gram-positive bacteria and mammalian cell lines, respectively.