2-methyl-5-dodecanone | 40238-96-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methyl-5-dodecanone
• 英文别名: 2-methyl-dodecan-5-one；2-Methyldodecan-5-one
• CAS: 40238-96-8
• 化学式: C₁₃H₂₆O
• 分子量: 198.349
• InChiKey: SMRKAPSTEFVTEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异己酰氯 、 二庚基镉 生成 2-methyl-5-dodecanone
  参考文献：
  名称：

  Structure and Reactivity. I. The Oximation Rates of Some Straight-Chain and Monomethyl-Substituted Alkanones

  摘要：

  DOI：

  10.1021/jo01029a022

文献信息

• BIFUNCTIONAL RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE
  申请人：INSPIRE PHARMACEUTICALS, INC.

  公开号：US20130131106A1

  公开（公告）日：2013-05-23

  This invention relates to synthetic bifunctional compounds comprising a first rho-associated kinase (ROCK) inhibiting compound and a second pharmaceutically active compound with complementary activity; the first and the second compounds are covalently linked by a biologically labile bond. This invention also relates to methods of making such compounds. The invention also relates to methods of using such bifunctional compounds in the prevention or treatment of diseases or conditions that are affected or can be assisted by altering the integrity or rearrangement of the cytoskeleton. Particularly, this invention relates to methods of treating ophthalmic diseases such as disorders in which intraocular pressure is elevated, for example primary open-angle glaucoma, using the bifunctional compounds.

  本发明涉及合成的双功能化合物，包括第一种抑制rho相关激酶(ROCK)的化合物和具有互补活性的第二种药物活性化合物；第一种和第二种化合物由生物可降解的化学键共价连接。本发明还涉及制备这种化合物的方法。本发明还涉及使用这种双功能化合物预防或治疗受到细胞骨架完整性或重组影响的疾病或病况的方法。特别地，本发明涉及使用这种双功能化合物治疗眼科疾病，例如原发性开角型青光眼等眼内压升高的疾病。
• Chinese traditional medicines for psoriasis
  申请人：——

  公开号：US20030152588A1

  公开（公告）日：2003-08-14

  The invention relates to disclose some Chinese formula for psoriasis. Whether treatment for psoriasis is targeted at both the hyperproliferative and inflammatory aspect of the topical therapy. Specially, the administration dosage is soft gel, cream, tincture and aerosol etc. topical dosages.
• [EN] BIFUNCTIONAL RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE<br/>[FR] COMPOSÉS INHIBITEURS DE RHO-KINASES BIFONCTIONNELS, COMPOSITION ET UTILISATION
  申请人：INSPIRE PHARMACEUTICALS INC

  公开号：WO2012012282A1

  公开（公告）日：2012-01-26

  This invention relates to synthetic bifunctional compounds comprising a first rho-associated kinase (ROCK) inhibiting compound and a second pharmaceutically active compound with complementary activity; the first and the second compounds are covalently linked by a biologically labile bond. This invention also relates to methods of making such compounds. The invention also relates to methods of using such bifunctional compounds in the prevention or treatment of diseases or conditions that are affected or can be assisted by altering the integrity or rearrangement of the cytoskeleton. Particularly, this invention relates to methods of treating ophthalmic diseases such as disorders in which intraocular pressure is elevated, for example primary open-angle glaucoma, using the bifunctional compounds.