Propan-2-yl 4-(acetyl{[3,5-bis(trifluoromethyl)phenyl]methyl}amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Propan-2-yl 4-(acetyl{[3,5-bis(trifluoromethyl)phenyl]methyl}amino)-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
• 英文别名: propan-2-yl 4-[acetyl-[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
• 化学式: C₂₇H₂₇F₉N₂O₃
• 分子量: 598.5
• InChiKey: TUPKOWFPVAXQFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  12

文献信息

• [EN] COMPOUNDS USEFUL AS INTERMEDIATES<br/>[FR] COMPOSES UTILES COMME INTERMEDIAIRES
  申请人：PFIZER PROD INC

  公开号：WO2002088069A2

  公开（公告）日：2002-11-07

  This invention relates compounds of formulae Wherein A is CN,CONH2 OR CONHCOOR, R being methyl or optionally substituted benzyl, useful as intermediates for cholesteryl ester transfer protein (CETP) inhibitors and methods for the preparation thereof.

  本发明涉及以下公式化合物，其中A为CN、CONH2或CONHCOOR，R为甲基或可选取代的苯甲基，作为胆固醇酯转移蛋白（CETP）抑制剂的中间体以及其制备方法。
• Methods for preparing CETP inhibitors
  申请人：Pfizer Inc.

  公开号：US20030216576A1

  公开（公告）日：2003-11-20

  This invention relates to methods for preparing certain cholesteryl ester transfer protein (CETP) inhibitors and intermediates useful in the preparation of said CETP inhibitors.

  这项发明涉及制备某些胆固醇酯转移蛋白（CETP）抑制剂及在制备该CETP抑制剂中有用的中间体的方法。
• Method for the preparation of pharmaceutical compositions comprising a solid amorphous dispersion of cholesteryl ester transfer protein inhibitors
  申请人：Bend Research, Inc.

  公开号：EP2305217A1

  公开（公告）日：2011-04-06

  A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.

  一种药物组合物由胆固醇酯转移蛋白抑制剂和浓度增强聚合物的固体无定形分散体组成。
• Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
  申请人：Pfizer Inc

  公开号：US20040122226A1

  公开（公告）日：2004-06-24

  Methods for the preparation of N-arylated oxazolidinone compounds via a copper catalyzed cross coupling reaction are disclosed.

  本发明公开了通过铜催化的交叉偶联反应制备 N-芳基化噁唑烷酮化合物的方法。
• 4-AMINO SUBSTITUTED-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS
  申请人：Pfizer Products Inc.

  公开号：EP1114032B1

  公开（公告）日：2004-06-02