N-[2-[3,5-dihydroxy-2-(hydroxymethyl)-6-[1,2,5-trihydroxy-6-oxo-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyhexan-3-yl]oxyoxan-4-yl]oxy-5-hydroxy-6-(hydroxymethyl)-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[2-[3,5-dihydroxy-2-(hydroxymethyl)-6-[1,2,5-trihydroxy-6-oxo-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyhexan-3-yl]oxyoxan-4-yl]oxy-5-hydroxy-6-(hydroxymethyl)-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide
• 化学式: C₃₂H₅₅NO₂₅
• 分子量: 853.8
• InChiKey: TVVLIFCVJJSLBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9.3
• 重原子数：
  58
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  424
• 氢给体数：
  16
• 氢受体数：
  25

反应信息

• 作为反应物：
  描述：

  D-GlcNAc 、 (β-D-galactopyranosyl)-(1->4)-(2-acetamido)-2-deoxy-β-D-glucopyranosyl)-(1->3)-(β-D-galactopyranosyl)-(1->4)-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-(1->3)-(β-D-galactopyranosyl)-(1->4)-α/β-D-glucopyranose 、 、 、 lacto-N-neo-tetraose 、 N-[2-[3,5-dihydroxy-2-(hydroxymethyl)-6-[1,2,5-trihydroxy-6-oxo-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyhexan-3-yl]oxyoxan-4-yl]oxy-5-hydroxy-6-(hydroxymethyl)-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide 、 Galbeta1-3GlcNAcbeta1-3Galbeta1-4(Fucalpha1-3)Glc 在 sugar 、 Galβ1-4GlcNAcβ1-3Galβ1-3GlcNAcβ1-3Galβ1-4Glc 作用下， 以produced as a secreted form in Example 10的产率得到Galbeta1-4GlcNAcbeta1-3Galbeta1-3GlcNAcbeta1-3Galbeta1-4(Fucalpha1-3)Glc
  参考文献：
  名称：

  USEFUL POLYPEPTIDES

  摘要：

  本发明提供了一种具有β1,3-N-乙酰葡萄糖胺基转移酶活性的新型多肽；一种制备该多肽的方法；编码该多肽的DNA；将该DNA插入重组载体的重组载体；包含重组载体的转化体；使用该多肽制备糖链或复杂碳水化合物的方法；使用该转化体制备糖链或复杂碳水化合物的方法；识别该多肽的抗体；筛选改变编码该多肽的基因表达的物质的方法；以及筛选改变该多肽活性的物质的方法。

  公开号：

  US20090068720A1

文献信息

• Useful polypeptides
  申请人：Sasaki Katsutoshi

  公开号：US20060030001A1

  公开（公告）日：2006-02-09

  The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.

  本发明提供了一种具有β1,3-N-乙酰葡萄糖胺基转移酶活性的新型多肽；一种生产该多肽的方法；一种编码该多肽的DNA；将该DNA插入的重组载体；包含重组载体的转化体；使用该多肽生产糖链或复杂碳水化合物的方法；使用转化体生产糖链或复杂碳水化合物的方法；识别该多肽的抗体；筛选改变编码该多肽的基因表达的物质的方法；以及筛选改变该多肽活性的物质的方法。
• Method of producing sugar chain using human G4 polypeptide
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：US07972815B2

  公开（公告）日：2011-07-05

  The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyl transferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.

  本发明提供了一种具有β1,3-N-乙酰葡萄糖胺基转移酶活性的新型多肽；一种制备该多肽的方法；编码该多肽的DNA；插入该DNA的重组载体；包含该重组载体的转化体；使用该多肽制备糖链或复杂碳水化合物的方法；使用该转化体制备糖链或复杂碳水化合物的方法；识别该多肽的抗体；筛选改变编码该多肽的基因表达的物质的方法；以及筛选改变该多肽活性的物质的方法。
• Process for producing carbohydrates using β 1,3-N-acetyl-glucosaminyltransferase
  申请人：Kyowa Hakko Kogyo Co., Ltd.

  公开号：US07005279B1

  公开（公告）日：2006-02-28

  The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.

  本发明提供了一种新型聚肽，具有β1,3-N-乙酰葡萄糖胺基转移酶活性；一种生产该聚肽的方法；编码该聚肽的DNA；将该DNA插入的重组载体；包含该重组载体的转化体；使用该聚肽生产糖链或复杂碳水化合物的方法；使用该转化体生产糖链或复杂碳水化合物的方法；识别该聚肽的抗体；筛选改变编码该聚肽的基因表达的物质的方法；以及筛选改变该聚肽活性的物质的方法。
• USEFUL POLYPEPTIDES
  申请人：Sasaki Katsutoshi

  公开号：US20090068720A1

  公开（公告）日：2009-03-12

  The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyl transferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the polypeptide; a method for producing a sugar chain or complex carbohydrate, using the transformant; an antibody which recognizes the polypeptide; a method for screening a substance which changes the expression of the gene which encodes the polypeptide; and a method for screening a substance which changes the activity of the polypeptide.

  本发明提供了一种具有β1,3-N-乙酰葡萄糖胺基转移酶活性的新型多肽；一种制备该多肽的方法；编码该多肽的DNA；将该DNA插入重组载体的重组载体；包含重组载体的转化体；使用该多肽制备糖链或复杂碳水化合物的方法；使用该转化体制备糖链或复杂碳水化合物的方法；识别该多肽的抗体；筛选改变编码该多肽的基因表达的物质的方法；以及筛选改变该多肽活性的物质的方法。