Methyl 2-benzoyl-4-(2-methoxyethoxy)-5-phenoxypentanoate | 1026542-31-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 2-benzoyl-4-(2-methoxyethoxy)-5-phenoxypentanoate
• CAS: 1026542-31-3
• 化学式: C₂₂H₂₆O₆
• 分子量: 386.445
• InChiKey: BBLAHCZCDFNFOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Methyl 2-benzoyl-4-(2-methoxyethoxy)-5-phenoxypentanoate 在 p-nitrobenzenesulfonyl azide 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 生成 Methyl 2-diazo-4-(2-methoxyethoxy)-5-phenoxypentanoate
  参考文献：
  名称：

  Diastereoselective Rh-Mediated Construction of 2,3,5-Trisubstituted Tetrahydrofurans

  摘要：

  Dirhodium(II) carboxylate catalyzed cyclization of a series of gamma-alkoxy-alpha-diazo esters 1 has been shown to proceed with substantial diastereoselectivity, producing the 2,3,5-trisubstituted tetrahydrofurans 2 and 3. The diastereoselectivity of the cyclization improved as the electron-withdrawing ability of the substituent R increased. A mechanistic hypothesis is presented.

  DOI：

  10.1021/jo960758u
• 作为产物：
  描述：

  苯甲酸甲酯 、 Methyl 4-(2-methoxyethoxy)-5-phenoxypentanoate 在 sodium hydride 作用下， 生成 Methyl 2-benzoyl-4-(2-methoxyethoxy)-5-phenoxypentanoate
  参考文献：
  名称：

  Diastereoselective Rh-Mediated Construction of 2,3,5-Trisubstituted Tetrahydrofurans

  摘要：

  Dirhodium(II) carboxylate catalyzed cyclization of a series of gamma-alkoxy-alpha-diazo esters 1 has been shown to proceed with substantial diastereoselectivity, producing the 2,3,5-trisubstituted tetrahydrofurans 2 and 3. The diastereoselectivity of the cyclization improved as the electron-withdrawing ability of the substituent R increased. A mechanistic hypothesis is presented.

  DOI：

  10.1021/jo960758u