5,8,11,13,16,19-六氧杂二十三烷 | 143-29-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 5,8,11,13,16,19-六氧杂二十三烷
• 英文名称: bis(diethylene glycol butyl ether)formal
• 英文别名: bis(2-(2-butoxyethoxy)ethoxy)methane；5,8,11,13,16,19-Hexaoxatricosane；1-[2-[2-[2-(2-butoxyethoxy)ethoxymethoxy]ethoxy]ethoxy]butane
• CAS: 143-29-3
• 化学式: C₁₇H₃₆O₆
• 分子量: 336.469
• InChiKey: DKWHHTWSTXZKDW-UHFFFAOYSA-N

物化性质

• 沸点：
  392.93°C (rough estimate)
• 密度：
  1.0497 (rough estimate)
• LogP：
  1.83 at 20℃
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  23
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 海关编码：
  2901100000

制备方法与用途

类别：有毒物品

毒性分级：中毒

急性毒性：

• 口服（大鼠）LD₅₀：1746毫克/公斤
• 口服（小鼠）LD₅₀：2700毫克/公斤

可燃性危险特性：可燃；燃烧时产生刺激烟雾

储运特性：库房需通风、低温干燥

灭火剂：干粉、泡沫、沙土、二氧化碳、雾状水

反应信息

• 作为产物：
  描述：

  二乙氧基甲烷 、 二乙二醇丁醚 在 phosphotungstic acid 作用下， 反应 1.5h， 生成 5,8,11,13,16,19-六氧杂二十三烷
  参考文献：
  名称：

  一种双二元醇单烷基醚缩甲醛的制备方法

  摘要：

  本发明公开了一种双二元醇单烷基醚缩甲醛的制备方法，以二乙氧基甲烷和二元醇单烷基醚为原料，在磷钨酸催化下，通过缩醛交换反应，获得双二元醇单烷基醚缩甲醛。本发明采用磷钨酸催化剂合成双二元醇单烷基醚缩甲醛，该催化剂用量少，催化活性高，对设备腐蚀性小，与产物分离容易，实现了催化剂的循环使用，是一种高效、绿色环保的生产方法。用二乙氧基甲烷替代甲醛为原料，大大降低了甲醛对环境的污染和对人体的危害，减少了废水的排放，提高了产品品质，符合绿色化学的理念。

  公开号：

  CN107827717B

文献信息

• 8-(Biaryl)quinoline pde4 inhibitors
  申请人：Dube Daniel

  公开号：US20050234238A1

  公开（公告）日：2005-10-20

  8-(biaryl) quinolines wherein the bi-aryl group at the 8-position is in a meta relationship to the quinoline group, are PDE4 inhibitors useful in the treatment of asthma, chronic bronchitis, chronic obstructive pulmonary disease, eosinophilic granuloma, psoriasis and other benign or malignant proliferative skin diseases, endotoxic shock, laminitis in horses, colic in horses, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and brain, inflammatory arthritis, chronic glomerulonephritis, atopic dermatitis, urticaria, adult respiratory distress syndrome, chronic obstructive pulmonary disease in animals, diabetes insipidus, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, arterial restenosis, ortherosclerosis, atherosclerosis, neurogenic inflammation, pain, cough, rheumatoid arthritis, ankylosing spondylitis, transplant rejection, graft versus host disease, hypersecretion of gastric acid, bacterial, fungal induced sepsis, viral induced sepsis, fungal induced septic shock, viral induced septic shock, inflammation-mediated chronic tissue degeneration, cytokine-mediated chronic tissue degeneration, osteoarthritis, cancer, cachexia, muscle wasting, depression, memory impairment, tumour growth, or cancerous invasion of normal tissues. In another aspect, the present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and cognition enhancing amount of a phosphodiesterase-4 inhibitor.

  8-(联苯基)喹啉中，8位位置的联苯基与喹啉基团呈间位关系，是PDE4抑制剂，可用于治疗哮喘、慢性支气管炎、慢性阻塞性肺疾病、嗜酸性粒细胞肉芽肿、银屑病和其他良性或恶性增生性皮肤疾病、内毒素休克、马蹄疾病、马腹绞痛、败血症休克、溃疡性结肠炎、克罗恩病、心肌和脑再灌注损伤、炎性关节炎、慢性肾小球肾炎、特应性皮炎、荨麻疹、成人呼吸窘迫综合症、动物慢性阻塞性肺疾病、尿崩症、过敏性鼻炎、过敏性结膜炎、春季结膜炎、动脉再狭窄、动脉硬化、神经源性炎症、疼痛、咳嗽、类风湿性关节炎、强直性脊柱炎、移植排斥、移植物抗宿主病、胃酸分泌过多、细菌、真菌引起的败血症、病毒引起的败血症、真菌引起的败血性休克、病毒引起的败血性休克、炎症介导的慢性组织退化、细胞因子介导的慢性组织退化、骨关节炎、癌症、消瘦、肌肉消耗、抑郁症、记忆障碍、肿瘤生长或癌细胞侵袭正常组织。另一方面，本发明还涉及一种增强健康受试者认知能力的方法，包括给予安全的认知增强剂量的磷酸二酯酶-4抑制剂。特别地，本发明涉及一种增强健康受试者记忆、学习、保留、回忆、意识和判断能力的方法，包括给予安全的认知增强剂量的磷酸二酯酶-4抑制剂。
• Synthesis of polyurethane products
  申请人：Hostettler, Fritz

  公开号：EP0152667A2

  公开（公告）日：1985-08-28

  @ There are provided a wide range of polyurethane products, e.g., cellular, dense elastomer, and integral skin mlcrocellular products, obtained by the reaction of (a) a polylsocyanate compound, (b) a polyol, (c) optionally a chain extender and/or blowing agent with/without other known additives, (d) in the presence of a nonhydroxyl flow modifier characterized by carbon and hydrogen atoms, at least one and, generally, a plurality of oxyalkylene groups, O I and at least one urethane, -NHCO-, group. Several of the polyurethane products exhibit unique properties, e.g., foamed articles with capability to conduct static electricity, soft elastomers characterized by improved coefficient or friction, etc. Several classes of the flow modifiers are novel per se. The polyurethane products can be synthesized via the one shot or prepolymer process. Multipackage systems, In particular, two and three component systems are useful In molding operations, e.g., manufacture of shoe soles.

  提供了多种聚氨酯产品，如：蜂窝状、致密弹性体和整体表皮的多孔产品、(a) 一种多异氰酸酯化合物；(b) 一种多元醇；(c) 一种可选的扩链剂和/或发泡剂（含/不含其他已知添加剂）；(d) 一种非羟基流动改性剂，其特征在于该流动改性剂含有碳原子和氢原子、至少一个（一般为多个）氧烷基 O I 和至少一个氨基甲酸酯基 -NHCO-。有几种聚氨酯产品具有独特的性能，例如，具有静电传导能力的发泡制品、具有改善摩擦系数特点的软弹性体等。有几类流动改性剂本身就很新颖。聚氨酯产品可通过一次成型或预聚工艺合成。多组分系统，特别是双组分和三组分系统在模塑操作中非常有用，例如鞋底的制造。
• Latex for coatings having improved flexibility
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP0501272A1

  公开（公告）日：1992-09-02

  This invention relates to the synthesis of a latex which can be formulated into coatings having improved flexibility and good water resistance. Coatings of this type are particularly useful in roof coating applications because they offer excellent flexibility, excellent ultra-violet light resistance, and good water resistance. The subject invention more specifically discloses a process for producing a neutralized latex that is useful in the manufacture of water reducible coatings which comprises: (1) free radical aqueous emulsion polymerizing, at a pH of less than about 3.5, a monomer mixture which comprises, based on 100 weight percent monomers: (a) from about 30 to about 70 weight percent vinyl aromatic monomers, (b) from about 25 to about 65 weight percent of at least one alkyl acrylate monomer, (c) from about 1 to about 5 weight percent of acrylic acid, and (d) about 0.4 to about 3 weight percent methacrylic acid; in the presence of about 0.2 to 0.4 phm at least one sulfonate surfactant and in the presence of about 4 to 8 phm of at least one nonionic surface active agent having a hydrophile-lipophile balance number which is within the range of about 12 to about 20 to produce a latex; and (2) neutralizing the latex with ammonia to a pH which is within the range of about 7 to about 10.5 to produce the neutralized latex.

  本发明涉及一种胶乳的合成，这种胶乳可以配制成具有更好柔韧性和良好耐水性的涂料。这种类型的涂料尤其适用于屋顶涂料应用，因为它们具有优异的柔韧性、优异的抗紫外线能力和良好的耐水性。本发明更具体地公开了一种生产中和胶乳的工艺，这种胶乳可用于制造可还原防水涂料，其工艺包括： 1： (1) 在 pH 值小于约 3.5 的条件下，对单体混合物进行自由基水乳液聚合，该单体混合物以 100 重量百分比的单体为基础包括：(a) 约 30 至约 70 重量百分比的乙烯基芳香族单体，(b) 约 25 至约 65 重量百分比的至少一种丙烯酸烷基酯单体，(c) 约 1 至约 5 重量百分比的丙烯酸，以及 (d) 约 0.4 至约 3 重量百分比的甲基丙烯酸；在约 0.2 至 0.4 phm 的至少一种磺酸盐表面活性剂和约 4 至 8 phm 的至少一种非离子表面活性剂的存在下，产生胶乳，该表面活性剂的亲水-亲脂平衡数在约 12 至约 20 的范围内；以及 (2) 用氨水将胶乳中和至 pH 值在约 7 至约 10.5 范围内，生成中和胶乳。
• Composition based on elastomeric polymers of vinylidene fluoride, suitable for providing microcellular foamed articles
  申请人：AUSIMONT S.p.A.

  公开号：EP0571807A1

  公开（公告）日：1993-12-01

  The present invention relates to compositions based on elastomeric polymers of vinylidene fluoride, hexafluoropropene and optionally tetrafluoroethylene suitable for providing microcellular foamed vulcanized articles by extrusion or compression molding. In the case of the production of extruded articles based on vinylidene fluoride and hexafluoropropene copolymers, the compositions comprise: the copolymer, bisphenol AF, a quaternary phosphonium or aminophosphonium salt, azodicarbonamide, MgO, Ca(OH)₂, zinc stearate and a plasticizer, each of the components being contained in an exactly defined proportion.

  本发明涉及基于偏氟乙烯、六氟丙烯和任选四氟乙烯弹性聚合物的组合物，适于通过挤压或压缩成型提供微孔发泡硫化制品。在生产以偏氟乙烯和六氟丙烯共聚物为基础的挤压制品时，组合物包括 共聚物、双酚 AF、季鏻盐或氨基鏻盐、偶氮二甲酰胺、氧化镁、Ca(OH)₂、硬脂酸锌和增塑剂，每种成分的含量都有精确的规定比例。
• Latex for coatings
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP0764666A2

  公开（公告）日：1997-03-26

  This invention relates to the synthesis of a latex which can be used in making water reducible coating compositions, such as paints, which contain no or extremely low levels of volatile organic compounds. Coatings which are formulated with the latex of this invention offer an environmental advantage as well as excellent flexibility, excellent ultra-violet light resistance, and good water resistance. This invention more specifically discloses a process for producing a neutralized latex that is useful in the manufacture of water reducible coatings which comprises: (1) free radical aqueous emulsion polymerizing, at a pH of less than about 3.5, a monomer mixture which comprises, based on 100 weight percent monomers: (a) from about 30 to about 70 weight percent vinyl aromatic monomers, (b) from about 25 to about 65 weight percent of 2-ethylhexyl acrylate, (c) from about 1 to about 5 weight percent of acrylic acid, and (d) about 0.4 to about 3 weight percent methacrylic acid to produce a latex; wherein said emulsion polymerization step is conducted in the presence of about 0.5 to about 4 phm at least one phosphate ester surfactant and in the presence of about 0.5 to 4 phm of at least one water insoluble nonionic surface active agent selected from the group consisting of nonionic surfactants having a hydrophile-lipophile balance number of less than about 12, fatty alcohols, and polyols which are copolymers of ethylene oxide and propylene oxide; and (2) neutralizing the latex with ammonia to a pH which is within the range of about 7 to about 10.5 to produce the neutralized latex.

  本发明涉及一种胶乳的合成，这种胶乳可用于制造不含挥发性有机化合物或挥发性有机化合物含量极低的可还原水涂料组合物，例如油漆。用本发明的胶乳配制的涂料具有环保优势，同时还具有优异的柔韧性、出色的抗紫外线能力和良好的耐水性。本发明更具体地公开了一种用于生产可还原水性涂料的中和胶乳的生产工艺，该工艺包括： 1： (1) 在 pH 值小于约 3.5 的条件下，对单体混合物进行自由基水乳液聚合，该单体混合物以 100 重量百分比的单体为基础，包括：(a) 约 30 至约 70 重量百分比的乙烯基芳香族单体，(b) 约 25 至约 65 重量百分比的丙烯酸 2-乙基己酯，(c) 约 1 至约 5 重量百分比的丙烯酸，以及 (d) 约 0.4 至约 3 重量百分比的甲基丙烯酸，以生产胶乳；其中所述乳液聚合步骤是在约 0.5至约4phm的至少一种磷酸酯表面活性剂的存在下，以及约0.5至4phm的至少一种不溶于水的非离子表面活性剂的存在下进行；该非离子表面活性剂选自由亲水-亲油平衡数小于约12的非离子表面活性剂、脂肪醇以及环氧乙烷和环氧丙烷的共聚物多元醇组成的组；以及 (2) 用氨水中和胶乳，使其 pH 值在约 7 至约 10.5 的范围内，生成中和胶乳。