a-Methyl glucuronic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: a-Methyl glucuronic acid
• 英文别名: 4,5,6-trihydroxy-3-methoxyoxane-2-carboxylic acid
• 化学式: C₇H₁₂O₇
• 分子量: 208.17
• InChiKey: WGLLPAPKWFDHHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• REMOTE DETECTION OF SUBSTANCE DELIVERY TO CELLS
  申请人：Drummond Daryl C.

  公开号：US20110104261A1

  公开（公告）日：2011-05-05

  The present invention provides for the development of endocytosis-sensitive probes, and a remote method for measuring cellular endocytosis. These probes are based on the reduced water permeability of a nanoparticle or liposomal delivery system, and inherent degradability or disruption of barrier integrity upon endocytosis. The invention also provides for liposomes having combined therapeutic and diagnostic utilities by co-encapsulating ionically coupled diagnostic and therapeutic agents, in one embodiment, by a method using anionic chelators to prepare electrochemical gradients for loading of amphipathic therapeutic bases into liposomes already encapsulating an imaging agent. The invention provides for imaging of therapeutic liposomes by inserting a lipopolymer anchored, remotely sensing reporter molecules into liposomal lipid layer. The invention allows for an integrated delivery system capable of imaging molecular fingerprints in diseased tissues, treatment, and treatment monitoring.
• LOW-MOLECULAR POLYSULFATED HYALURONIC ACID DERIVATIVE AND MEDICINE CONTAINING SAME
  申请人：Kakehi Kazuaki

  公开号：US20110281819A1

  公开（公告）日：2011-11-17

  A low-molecular-weight polysulfated hyaluronic acid derivative useful for prevention and/or treatment of an allergic disease. An agent for prevention and/or treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); wherein n represents a number of 0 to 15; R′s each independently represent a hydrogen atom or an SO 3 H group etc.
• US8993536B2
  申请人：——

  公开号：US8993536B2

  公开（公告）日：2015-03-31