O-Acetyl-digitoxigenin | 808-19-5

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: O-Acetyl-digitoxigenin
• 英文别名: Digitoxigenin-3-acetat；3-beta-Acetoxy-14-hydroxy-5-beta,14-beta-card-20(22)-enolide；[14-hydroxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl] acetate
• CAS: 808-19-5；5041-05-4；5041-06-5；6901-37-7；22040-82-0；24511-75-9；33022-18-3；111900-78-8；114376-37-3；122211-84-1；124152-50-7
• 化学式: C₂₅H₃₆O₅
• 分子量: 416.558
• InChiKey: WJOGTCZNZPHODB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 危险等级：
  6.1(a)

文献信息

• Improved process for the preparation of 3 beta, 14 beta-dihydroxyethialnaldehyde
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0684256A2

  公开（公告）日：1995-11-29

  A process for producing 3β, 14β-dihydroxyethianaldehyde is disclosed wherein the oxidation of the lactone ring of digitoxigenin-3-acetate is conducted with an alkaline periodate in the presence of a catalytic amount of ruthenium tetroxide obtained in situ by reacting RuO2 hydrate or RuCl3 with the alkaline periodate.

  本发明公开了一种生产 3β，14β-二羟基乙醛的工艺，其中地高辛-3-乙酸酯的内酯环的氧化是在通过使 RuO2 水合物或 RuCl3 与碱性高碘酸盐反应而就地获得的催化量的四氧化钌的存在下，用碱性高碘酸盐进行的。
• MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES FOR THE TREATMENT OF OCULAR DISORDERS
  申请人：Bionaut Pharmaceuticals

  公开号：EP1928470A2

  公开（公告）日：2008-06-11
• Modulators of Hypoxia Inducible Factor-1 and Related Uses for the Treatment of Ocular Disorders
  申请人：Khodadoust Mehran

  公开号：US20110076278A1

  公开（公告）日：2011-03-31

  Methods for treatment of ocular disorders using steroids modulate the effects of local and systemic hypoxic events mediated by hypoxia inducible factor-1 (HIF-1). Steroids that are useful as HIF-1 modulators include bufalin, digitoxigenin, digoxin, lanatoside C, strophantin K, uzarigenin, ouabain and proscillaridin. In some embodiments the ocular disorder is characterized by ischmia.
• US5596110A
  申请人：——

  公开号：US5596110A

  公开（公告）日：1997-01-21
• [EN] MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES FOR THE TREATMENT OF OCULAR DISORDERS<br/>[FR] MODULATEURS DU FACTEUR 1 INDUIT PAR HYPOXIE ET UTILISATIONS ASSOCIEES DANS LE TRAITEMENT DE TROUBLES OCULAIRES
  申请人：BIONAUT PHARMACEUTICALS

  公开号：WO2007016656A2

  公开（公告）日：2007-02-08

  (EN) Methods for treatment of ocular disorders using steroids modulate the effects of local and systemic hypoxic events mediated by hypoxia inducible factor- 1 (HIF-1). Steroids that are useful as HIF-1 modulators include bufalin, digitoxigenin, digoxin, lanatoside C, strophantin K, uzarigenin, ouabain and proscillaridin. In some embodiments the ocular disorder is characterized by ischmia.(FR) L'invention concerne des méthodes de traitement de troubles oculaires à l'aide de composés modulant les effets d'évènements hypoxiques locaux et systémiques.