1-Isobutyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Isobutyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde
• 英文别名: 1-(2-methylpropyl)-2-oxoquinoline-3-carbaldehyde
• 化学式: C₁₄H₁₅NO₂
• mdl: MFCD06738237
• 分子量: 229.27
• InChiKey: YNUXUYBQJKXQHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NOVEL 2-QUINOLONE DERIVATIVE
  申请人：Ikeda Kazuhito

  公开号：US20090131412A1

  公开（公告）日：2009-05-21

  A compound represented by the formula (1) or a pharmaceutically acceptable salt thereof which has a therapeutic or prophylactic effect on an SNS-related disease such as neuropathic pain. (1) wherein R 1 and R 2 independently represent an alkyl group having 1 to 4 carbon atoms or the like, or R 1 and R 2 may together form a 5- to 7-membered ring; n represents a numerical number of 1 to 3; A represents a substituted or unsubstituted aryl group or the like or a formula: —N(R 5 )R 6 (wherein R 5 and R 6 independently represent a substituted or unsubstituted alkyl group or the like); and R 3 and R 4 independently represent a substituted or unsubstituted alkyl group or the like, or R 3 and R 4 may together form a substituted or unsubstituted, saturated or unsubstituted nitrogenated heterocyclic ring, provided that both of R 1 and R 2 are not a hydrogen atom when R 3 and R 4 together form a piperidine ring.