1-(4-Hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione | 918629-54-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 1-(4-Hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione
• CAS: 918629-54-6
• 化学式: C₁₄H₁₆O₄
• 分子量: 248.27
• InChiKey: YSLKZSXJKBKPMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste
  申请人：Ley Jakob

  公开号：US20080227866A1

  公开（公告）日：2008-09-18

  The use of a hydroxyphenylalkadione derivative of the formula (I) wherein, for X, a and Y: X is a —CH 2 —, —NH— or —O— group, Y is a —CH 2 — group and a is a single bond or X and Y are in each case a —CH— group and a is a double bond in the Z or E configuration, wherein, for R 1 , R 2 and R 3 R 1 denotes hydrogen, an aliphatic radical having 1 to 4 C atoms or a —O—R 5 , —S—R 5 or —NR 5 R 6 group and R 2 and R 3 independently of one another denote hydrogen or an alkyl having 1, 2, 3, 4 or 5 C atoms which is optionally substituted by one or more oxo groups or R 7 —O— groups or R 1 and R 2 together form an aliphatic ring which contains a total of 4 to 10 carbon atoms and 0 or 1 oxygen atom, wherein the ring constituent represented by R 1 and R 2 is optionally substituted by one or more oxo groups and/or R 7 —O— groups and/or aliphatic radicals having 1 to 4 C atoms and R 3 denotes hydrogen or an alkyl having 1, 2, 3, 4 or 5 C atoms which is optionally substituted by one or more oxo groups or R 7 —O— groups or R 2 and R 3 together form an aliphatic ring which contains a total of 4 to 10 carbon atoms and 0 or 1 oxygen atom, wherein the ring constituent represented by R 2 and R 3 is optionally substituted by one or more oxo groups and/or R 7 —O— groups and/or aliphatic radicals having 1 to 4 C atoms and R 1 denotes hydrogen, an aliphatic radical having 1 to 4 C atoms or a —O—R 5 , —S—R 5 or —NR 5 R 6 group, wherein, for R 4 and R: R 4 and R independently of one another denote hydrogen, methyl or ethyl and wherein, for R 5 , R 6 and R 7 : R 5 , R 6 and R 7 independently of one another denote hydrogen or an aliphatic radical having 1 to 4 C atoms, a salt of such a hydroxyphenylalkadione of the formula (I), a mixture comprising or consisting of two or more different hydroxyphenylalkadiones of the formula (I), wherein X, a, Y, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 in each case have the meaning given above, a mixture comprising or consisting of salts of two or more different hydroxyphenylalkadiones of the formula (I), wherein X, a, Y, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 in each case have the meaning given above, or a mixture comprising or consisting of a hydroxyphenylalkadione of the formula (I) or two or more different hydroxyphenylalkadiones of the formula (I), wherein X, a, Y, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 in each case have the meaning given above, and a salt of a hydroxyphenylalkadione of the formula (I) or two or more salts of different hydroxyphenylalkadiones of the formula (I), wherein X, a, Y, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 in each case have the meaning given above, for modifying, masking or reducing the unpleasant flavour impression of an unpleasantly tasting substance and/or for intensifying the sweet taste of a sweet-tasting substance and/or the sweet odour impression of an aroma substance which causes a sweet odour impression, as well as formulations and processes including a hydroxyphenylalkadione of the formula (I), are described.

  本文描述了使用公式（I）的羟基苯基丙酮衍生物的用途，其中，对于X、a和Y： X是一个-CH2-，-NH-或-O-基团， Y是一个- -基团， a是一个单键； 或者X和Y在每种情况下都是一个-CH-基团，并且在Z或E构型中有一个双键； 对于R1、R2和R3，它们分别表示氢、具有1至4个C原子的脂肪基或-O-R5、-S-R5或-NR5R6基团； R2和R3独立地表示氢或具有1、2、3、4或5个C原子的烷基，该烷基可以被一个或多个氧化基团或R7-O-基团取代； 或者R1和R2共同形成一个含有4至10个碳原子和0或1个氧原子的脂肪环，其中由R1和R2表示的环组分可以选择地被一个或多个氧化基团和/或R7-O-基团和/或具有1至4个C原子的脂肪基取代，而R3表示氢或具有1、2、3、4或5个C原子的烷基，该烷基可以被一个或多个氧化基团或R7-O-基团取代； 或者R2和R3共同形成一个含有4至10个碳原子和0或1个氧原子的脂肪环，其中由R2和R3表示的环组分可以选择地被一个或多个氧化基团和/或R7-O-基团和/或具有1至4个C原子的脂肪基取代； R1表示氢、具有1至4个C原子的脂肪基或-O-R5、-S-R5或-NR5R6基团； 对于R4和R： R4和R分别独立地表示氢、甲基或乙基； 对于R5、R6和R7： R5、R6和R7分别独立地表示氢或具有1至4个C原子的脂肪基； 本文还描述了使用公式（I）的羟基苯基丙酮衍生物的盐，包括或仅包括两种或两种以上不同的公式（I）的羟基苯基丙酮衍生物的混合物，其中X、a、Y、R、R1、R2、R3、R4、R5、R6和R7在每种情况下具有上述给定的含义，以及包括公式（I）的羟基苯基丙酮衍生物的制剂和过程，用于修改、掩盖或减少令人不愉快的味道物质的不愉快的口感印象，以及用于增强甜味物质的甜味和/或引起甜味印象的香气物质的甜味气味印象。
• Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0245825B1

  公开（公告）日：1991-03-13
• HYDROXYPHENYLALKADIONES AND THEIR USE FOR MASKING BITTER TASTE AND/OR FOR INTENSIFYING SWEET TASTE
  申请人：Symrise GmbH & Co. KG

  公开号：EP1901618B1

  公开（公告）日：2009-06-17