8,2'-dimethoxyflavone | 115713-42-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 8,2'-dimethoxyflavone
• 英文别名: 8-methoxy-2-(2-methoxyphenyl)chromen-4-one
• CAS: 115713-42-3
• 化学式: C₁₇H₁₄O₄
• 分子量: 282.296
• InChiKey: ZLUNDKGGMHFJPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8,2'-dimethoxyflavone 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 8,2'-dihydroxyflavone
  参考文献：
  名称：

  来自 Primula pulverulenta 的 8,2'-二羟基黄酮

  摘要：

  摘要 从 Primula pulverulenta 的粉糖分泌物中分离出一种新的黄酮，被鉴定为 8,2'-二羟基黄酮。这是第一个天然存在的黄酮，其中环 A 仅在 C-8 处被氧化。该结构是从与结构相关的黄酮的光谱比较中推导出来的：5,2'-、3,2'-和 2',3'-二羟基黄酮，并通过全合成证实。与 8,2'-二羟基黄酮相关地讨论了具有简单模式的其他黄酮氧合的光谱特性。

  DOI：

  10.1016/0031-9422(88)80220-6
• 作为产物：
  描述：

  1-(2-羟基-3-甲氧苯基)乙酮 在 氢氧化钾 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 1,4-二氧六环 、 乙二醇甲醚 为溶剂， 反应 7.0h， 生成 8,2'-dimethoxyflavone
  参考文献：
  名称：

  来自 Primula pulverulenta 的 8,2'-二羟基黄酮

  摘要：

  摘要 从 Primula pulverulenta 的粉糖分泌物中分离出一种新的黄酮，被鉴定为 8,2'-二羟基黄酮。这是第一个天然存在的黄酮，其中环 A 仅在 C-8 处被氧化。该结构是从与结构相关的黄酮的光谱比较中推导出来的：5,2'-、3,2'-和 2',3'-二羟基黄酮，并通过全合成证实。与 8,2'-二羟基黄酮相关地讨论了具有简单模式的其他黄酮氧合的光谱特性。

  DOI：

  10.1016/0031-9422(88)80220-6

文献信息

• WOLLENWEBER, ECKHARD;MANN, KARIN;IINUMA, MUNEKAZU;TANAKA, TOSHIYUKI;MIZUN+, PHYTOCHEMISTRY, 27,(1988) N 5, 1483-1486
  作者：WOLLENWEBER, ECKHARD、MANN, KARIN、IINUMA, MUNEKAZU、TANAKA, TOSHIYUKI、MIZUN+

  DOI：——

  日期：——
• COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING RADIATION INJURY
  申请人：The Johns Hopkins University

  公开号：EP2362770A2

  公开（公告）日：2011-09-07
• Methods and compositions for treating metabolic disorders
  申请人：Mootha Vamsi Krishna

  公开号：US20090143279A1

  公开（公告）日：2009-06-04

  The present invention provides methods of treating of disorders characterized by defective mitochondrial activity. In particular compounds of the present invention can be used in the treatment metabolic diseases and neurodegenerative diseases. The methods are also useful to increase oxidative phosphorylation or to decrease reactive oxygen species (ROS) production in a subject in need thereof.
• SYSTEMS AND METHODS FOR IDENTIFYING COMBINATIONS OF COMPOUNDS OF THERAPEUTIC INTEREST
  申请人：Califano Andrea

  公开号：US20090269772A1

  公开（公告）日：2009-10-29

  Systems, methods, and apparatus for searching for a combination of compounds of therapeutic interest are provided. Cell-based assays are performed, each cell-based assay exposing a different sample of cells to a different compound in a plurality of compounds. From the cell-based assays, a subset of the tested compounds is selected. For each respective compound in the subset, a molecular abundance profile from cells exposed to the respective compound is measured. Targets of transcription factors and post-translational modulators of transcription factor activity are inferred from the molecular abundance profile data using information theoretic measures. This data is used to construct an interaction network. Variances in edges in the interaction network are used to determine the drug activity profile of compounds in the subset of compounds. The drug activity profiles are used to form a filter set of compound combinations from the subset of compounds.
• COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING
  申请人：Bulawa Christine

  公开号：US20100305068A1

  公开（公告）日：2010-12-02

  Disclosed are compositions and methods for modulating protein trafficking and treating or preventing disorders characterized by impaired protein trafficking. Also disclosed are methods for producing a protein and identifying compounds that rescue protein trafficking defects.