isoplagiochin E

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: isoplagiochin E
• 英文别名: dihydroisoplagiochin A；14-oxapentacyclo[21.3.1.12,6.19,13.015,20]nonacosa-1(26),2,4,6(29),9(28),10,12,15(20),16,18,23(27),24-dodecaene-3,18,26-triol
• 化学式: C₂₈H₂₄O₄
• 分子量: 424.496
• InChiKey: ZXMDLMHTDQAKML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  32
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  isoplagiochin B 在 platinum(IV) oxide 、 氢气 作用下， 生成 isoplagiochin E
  参考文献：
  名称：

  Antimitotic activity of two macrocyclic bis(bibenzyls), isoplagiochins A and B from the Liverwort Plagiochila fruticosa

  摘要：

  Two bis(bibenzyls), isoplagiochins A (1) and B (2) have been isolated by the guidance of inhibitory effect of tubulin polymerization from the liverwort Plagiochila fruticosa (Plagiochilaceae). Isoplagiochins A and B inhibited the polymerization of tubulin at IC(50) 50 and 25 mu M, respectively. Furthermore structure-activity relationship based on their conformations was discussed. The presence of two aromatic rings which can be connected through two atoms bridge spacer of double bond may serve to maintain the backbone conformation. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.036

文献信息

• Antimitotic activity of two macrocyclic bis(bibenzyls), isoplagiochins A and B from the Liverwort Plagiochila fruticosa
  作者：Hiroshi Morita、Yuichiro Tomizawa、Tomoe Tsuchiya、Yusuke Hirasawa、Toshihiro Hashimoto、Yoshinori Asakawa

  DOI：10.1016/j.bmcl.2008.11.036

  日期：2009.1

  Two bis(bibenzyls), isoplagiochins A (1) and B (2) have been isolated by the guidance of inhibitory effect of tubulin polymerization from the liverwort Plagiochila fruticosa (Plagiochilaceae). Isoplagiochins A and B inhibited the polymerization of tubulin at IC(50) 50 and 25 mu M, respectively. Furthermore structure-activity relationship based on their conformations was discussed. The presence of two aromatic rings which can be connected through two atoms bridge spacer of double bond may serve to maintain the backbone conformation. (C) 2008 Elsevier Ltd. All rights reserved.