4-(5-(4-(dihexylamino)phenyl)thiophene-2-yl)-1-methylpyridinium trifluoromethanesulfonate | 1236567-78-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 4-(5-(4-(dihexylamino)phenyl)thiophene-2-yl)-1-methylpyridinium trifluoromethanesulfonate
• 英文别名: 4-{5-[4-(dihexylamino) phenyl] thiophene-2-yl} 1-methyl pyridinium trifluoromethane sulfonate；{4-[5-(4-dihexylamino)phenyl]thiophene-2-yl}-1-methyl pyridinium trifluoromethane sulfonate；4-(5-(4-(Dihexylamino)phenyl)thiophen-2-yl)-1-methylpyridinium trifluoromethanesulfonate；N,N-dihexyl-4-[5-(1-methylpyridin-1-ium-4-yl)thiophen-2-yl]aniline;trifluoromethanesulfonate
• CAS: 1236567-78-4
• 化学式: CF₃O₃S*C₂₈H₃₉N₂S
• 分子量: 584.767
• InChiKey: DLYXUXOMJOREBY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  7.93
• 重原子数：
  39
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  对碘苯胺 在 四(三苯基膦)钯 sodium carbonate 、 potassium carbonate 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 32.5h， 生成 4-(5-(4-(dihexylamino)phenyl)thiophene-2-yl)-1-methylpyridinium trifluoromethanesulfonate
  参考文献：
  名称：

  EP2395055

  摘要：

  公开号：

文献信息

• Spectral Shifts of the Environment-sensitive Fluorophore POLARIC™ in Heterogeneous Interfaces
  作者：Sang-Hyun Son、Yutaka Yamagishi、Michiko Tani、Maiko Yuasa、Koji Yamada

  DOI：10.1246/cl.2011.989

  日期：2011.9.5

  We have designed and synthesized amphiphilic environment-sensitive fluorophore, POLARIC™, from four building blocks using Suzuki–Miyaura cross-coupling. The absorption and fluorescence spectra were measured in various micelles and vesicles. The results show that the emission wavelengths of these probes respond to the surface charge and stability of the self-assemblies.

  我们通过Suzuki-Miyaura交叉偶联反应从四个构筑单元设计并合成了具有两亲性和环境敏感性的荧光团POLARIC™。我们测量了它在不同微胞和囊泡中的吸收和荧光光谱。结果表明，这些探针的发射波长会响应自组装体的表面电荷和稳定性。
• FLUORESCENT SOLVATOCHROMIC PIGMENT
  申请人：National University Corporation Hokkaido University

  公开号：EP2395055A1

  公开（公告）日：2011-12-14

  The present invention presents a novel fluorescent solvatochromic dye that (1) has an ionic terminal that makes it easier to use n a hydrophilic surface or in polar solvents, (2) can be efficiently excited by commonly used Argon lasers (488 nm), (3) shifts the wavelength of emitted light according to the change of polarity, and (4) can effectively stain living tissues such as cells and the like. A pyridinium group was introduced to the electron attracting group of the neutral fluorescent solvatochromic dye (Japanese Patent Application Public Disclosure No. 20008-291210 A) displaying an excellent emission wavelength response and synthesized a fluorescent solvatochromic dye. Then it was found that the fluorescence wavelength of the fluorescent solvatochromic dye changed extensively when the polarity changed on a hydrophilic surface and that the fluorescent solvatochromic dye, when altered to a cationic form, stained cell membranes and could be used to observe the behavior thereof.

  本发明提出了一种新型荧光增溶变色染料，该染料 (1) 具有离子端，更易于在亲水性表面或极性溶剂中使用，(2) 可被常用的氩激光器（488 nm）有效激发，(3) 可根据极性变化改变发射光的波长，(4) 可有效染色细胞等活体组织。 在中性荧光溶色染料（日本专利申请公开号 20008-291210 A）的引电子基团上引入吡啶鎓基团，显示出优异的发射波长响应，合成了一种荧光溶色染料。然后发现，当亲水表面的极性发生变化时，荧光溶色染料的荧光波长会发生很大变化，当荧光溶色染料转变为阳离子形式时，可以对细胞膜进行染色，并可用于观察其行为。