[(4S)-2-Oxo-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,9-dioxatricyclo[5.3.1.04,11]undeca-1(10),5-dien-6-yl]methyl acetate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(4S)-2-Oxo-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,9-dioxatricyclo[5.3.1.04,11]undeca-1(10),5-dien-6-yl]methyl acetate
• 化学式: C₁₈H₂₂O₁₁
• 分子量: 414.4
• InChiKey: IBIPGYWNOBGEMH-AEFNDFPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
  申请人：Scaramuzzino, Giovanni

  公开号：EP1336602A1

  公开（公告）日：2003-08-20

  New pharmaceutical compounds of general formula (I): F-(X)q where q is an integer from 1 to 5, preferably 1; -F is chosen among drugs described in the text, -X is chosen among 4 groups -M, -T, -V and -Y as described in the text. The compounds of general formula (I) are nitrate prodrugs which can release nitric oxide in vivo in a controlled and selective way and without hypotensive side effects and for this reason they are useful for the preparation of medicines for prevention and treatment of inflammatory, ischemic, degenerative and proliferative diseases of musculoskeletal, tegumental, respiratory, gastrointestinal, genito-urinary and central nervous systems.

  通式（I）的新药物化合物：F-（X）q，其中q是1到5的整数，最好是1；-F是在文本中描述的药物中选择的，-X是在文本中描述的4个组-M，-T，-V和-Y中选择的。通式（I）的化合物是硝酸盐前药，可以在体内以受控和选择性的方式释放一氧化氮，而不会产生降压副作用，因此它们非常适用于制备用于预防和治疗肌肉骨骼，皮肤，呼吸，消化，泌尿和中枢神经系统的炎症，缺血，退行性和增生性疾病的药物。
• Hair dyeing
  申请人：TOKIWA KANPO PHARMACEUTICAL CO., LTD.

  公开号：EP0440494A2

  公开（公告）日：1991-08-07

  An iridoid glycoside, or an aglycone thereof, is used to dye hair, and for the manufacture of a cosmetic for dyeing hair.

  鸢尾甙或其苷元可用于染发和制造染发化妆品。
• Morinda citrifolia (Noni) enhanced animal food product
  申请人：Morinda, Inc.

  公开号：EP1250849A1

  公开（公告）日：2002-10-23

  The present invention advances prior art animal food products by providing an animal food product formulated with Morinda Citrifolia, or Noni, from the Indian Mulberry plant. The addition of Noni to the animal food product of the present invention serves to provide significant health advantages not found in prior art animal food products.

  本发明提供了一种用印度桑科植物海巴戟或诺丽配制的动物食品，从而改进了现有的动物食品。在本发明的动物食品中添加诺丽，可提供现有动物食品所不具备的显著健康优势。
• Morinda citrifolia-based formulation as lipoxygenase inhibitor
  申请人：Morinda, Inc.

  公开号：EP1604675A1

  公开（公告）日：2005-12-14

  The present invention is directed to methods and formulations for inhibiting Lipoxygenase enzymes that function to biosynthesize or metabolize arachidonic acid into its intermediate Leukotriene constituents, as well as a method and formulation for treating and preventing diseases, including inflammatory diseases, and the symptoms associated with such diseases. The present invention methods and formulations effectively function as such through the introduction into the body (e.g. ingesting) a safe, pre-determined dosage of a naturaceutical composition formulated with or comprising one or more processed Morinda citrifolia products for a safe, pre-determined duration, wherein the processed Morinda citrifolia product may comprise one or more isolated active ingredients.

  本发明涉及抑制花生四烯酸生物合成或代谢为中间体白三烯成分的脂氧合酶的方法和制剂，以及治疗和预防疾病（包括炎症性疾病）和与此类疾病相关症状的方法和制剂。本发明的方法和制剂通过在安全、预定的持续时间内将一种或多种巴戟天加工产品配制或包含的天然药物组合物按安全、预定的剂量引入体内（如摄入），从而有效地发挥上述作用，其中巴戟天加工产品可包含一种或多种分离的活性成分。
• Inhibition of histone deacetylase and of tumor necrosis factor converting enzyme
  申请人：Morinda, Inc.

  公开号：EP1726309A1

  公开（公告）日：2006-11-29

  The present invention relates to methods and compositions for inhibiting Histone Deacetylase ("HDAC") and/or Tumor Necrosis Factor Converting Enzyme ("TACE") in living organisms. More particularly, the present invention relates to methods and compositions involving the inhibition of HDAC and/or TACE using processed Morinda citrifolia L. plant products.

  本发明涉及在生物体内抑制组蛋白去乙酰化酶（"HDAC"）和/或肿瘤坏死因子转换酶（"TACE"）的方法和组合物。更具体地说，本发明涉及使用加工的海巴戟植物产品抑制 HDAC 和/或 TACE 的方法和组合物。