1-cyclohexyl-5,6-dihydro[1,2,3]triazolo[5,1-a]isoquinoline | 1258271-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-cyclohexyl-5,6-dihydro[1,2,3]triazolo[5,1-a]isoquinoline
• CAS: 1258271-66-7
• 化学式: C₁₆H₁₉N₃
• 分子量: 253.347
• InChiKey: SGCDQKNZKHYEAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.55
• 重原子数：
  19.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  30.71
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  1-[2-(2-bromophenyl)ethyl]-4-cyclohexyl-1H-1,2,3-triazole 在 bis-triphenylphosphine-palladium(II) chloride 、 四丁基醋酸铵 作用下， 以 N-甲基吡咯烷酮 为溶剂， 以87%的产率得到1-cyclohexyl-5,6-dihydro[1,2,3]triazolo[5,1-a]isoquinoline
  参考文献：
  名称：

  An easy synthetic approach to 1,2,3-triazole-fused heterocycles

  摘要：

  A convenient synthesis of 1,2,3-triazole-fused isoindolines and dihydroisoquinolines in good to excellent yield is reported, starting from easily available terminal alkynes and (2-haloaryl)alkylazides. The method is based upon a cycloaddition reaction, via click chemistry, followed by a transition metal-catalyzed functionalization of a C-H bond. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.09.068

文献信息

• An easy synthetic approach to 1,2,3-triazole-fused heterocycles
  作者：Vito Fiandanese、Giuseppe Marchese、Angela Punzi、Francesco Iannone、Giacomo G. Rafaschieri

  DOI：10.1016/j.tet.2010.09.068

  日期：2010.11

  A convenient synthesis of 1,2,3-triazole-fused isoindolines and dihydroisoquinolines in good to excellent yield is reported, starting from easily available terminal alkynes and (2-haloaryl)alkylazides. The method is based upon a cycloaddition reaction, via click chemistry, followed by a transition metal-catalyzed functionalization of a C-H bond. (C) 2010 Elsevier Ltd. All rights reserved.