2,5-Diacetyl-phenol | 477727-57-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-Diacetyl-phenol
• 英文别名: 1,1'-(2-Hydroxy-1,4-phenylene)di(ethan-1-one)；1-(4-acetyl-3-hydroxyphenyl)ethanone
• CAS: 477727-57-4
• 化学式: C₁₀H₁₀O₃
• 分子量: 178.188
• InChiKey: CHSUVWIYVDZSCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 2,5-Diacetyl-phenol
  参考文献：
  名称：

  505. Cinnolines。第二十一部分。关于Richter综合的进一步观察

  摘要：

  DOI：

  10.1039/jr9490002393

文献信息

• Acetamide/SO2Cl2 as an efficient reagent for Friedel–Craft’s acylation of aromatic compounds under ultrasonic and microwave conditions
  作者：Mukka Satish Kumar、Kamatala Chinna Rajanna、Purugula Venkanna、Marri Venkateswarlu

  DOI：10.1016/j.tetlet.2014.01.099

  日期：2014.3

  developed for effective Friedel–Craft’s acylation of aromatic compounds. Acylation of aromatic compounds with acetamide/SO2Cl2 was much more effective and faster than analogous (acetamide/SOCl2) and (acetamide/POCl3) reagents even under conventional conditions. However, microwave and ultrasonic assisted reactions afforded high yields of products in very short reaction times (30–40 min under sonication and 3–4 min

  已开发出乙酰胺/ SO 2 Cl 2试剂，用于有效地进行Friedel-Craft芳族化合物的酰化反应。即使在常规条件下，与类似的（乙酰胺/ SOCl 2）和（乙酰胺/ POCl 3）试剂相比，用乙酰胺/ SO 2 Cl 2酰化芳族化合物也更有效和更快。但是，微波和超声辅助反应可在非常短的反应时间内（在超声处理下30–40分钟，在微波辅助条件下3-4分钟）提供高产率的产品。
• Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0587311A1

  公开（公告）日：1994-03-16

  Compounds of formula (I) : [wherein: R¹ is hydrogen, alkyl, aralkyl, -CORa, -CORb, -CSRa, -CSRb, -SO₂Rb, -CONHRb, -CSNHRb, -CONRbRb or -CSNRbRb; R² is hydrogen or alkyl; R³ is hydrogen, alkylidene, substituted alkyl, or Rb; R⁴ is optionally substituted alkyl, cycloalkyl, or aryl; R⁵ is RbO-, RbRbN-, RbHN-, aralkyloxycarbonyloxy or aralkyloxycarbonylamino, or R⁵ is -(CH₂)p-D-(CH₂)r- [where D is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and p and r are each 0 or an integer from 1 to 5]; A is -(CH₂)m-B-(CH₂)n- [where B is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and m and n are each 0 or an integer from 1 to 5]; Ra is alkoxy, aralkyloxy, aryloxy or alkoxycarbonyl; Rb is optionally substituted alkyl, cycloalkyl, heterocyclic, aryl or arylalkenyl]; and pharmaceutically acceptable salts and esters thereof and pro-drugs therefor, have the ability to inhibit the activity of HIV protease and may thus be used for the treatment and prophylaxis of AIDS.

  化合物的化学式为(I)：[其中：R¹为氢，烷基，芳基烷基，-CORa，-CORb，-CSRa，-CSRb，-SO₂Rb，-CONHRb，-CSNHRb，-CONRbRb或-CSNRbRb；R²为氢或烷基；R³为氢，烷基亚甲基，取代烷基或Rb；R⁴为可选取代的烷基，环烷基或芳基；R⁵为RbO-，RbRbN-，RbHN-，芳基烷氧羰氧基氧或芳基烷氧羰氨基，或R⁵为-(CH₂)p-D-(CH₂)r- [其中D为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；p和r分别为0或1到5的整数]；A为-(CH₂)m-B-(CH₂)n- [其中B为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；m和n分别为0或1到5的整数]；Ra为烷氧基，芳基烷氧基，芳氧基或烷氧羰基；Rb为可选取代的烷基，环烷基，杂环，芳基或芳基烷烯基]；以及其药学上可接受的盐和酯以及其前药，具有抑制HIV蛋白酶活性的能力，因此可用于治疗和预防艾滋病。
• US5629406A
  申请人：——

  公开号：US5629406A

  公开（公告）日：1997-05-13
• US7799913B2
  申请人：——

  公开号：US7799913B2

  公开（公告）日：2010-09-21