(2-Hydroxy)propylimidazole | 67106-66-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (2-Hydroxy)propylimidazole
• 英文别名: 1,3-diazolyl-2-propanol；2-(2-Hydroxypropyl)-imidazol；1-(1H-imidazol-2-yl)propan-2-ol
• CAS: 67106-66-5
• 化学式: C₆H₁₀N₂O
• 分子量: 126.158
• InChiKey: JHSNSAFVQQRHAD-UHFFFAOYSA-N

物化性质

• 沸点：
  353.3±25.0 °C(Predicted)
• 密度：
  1.166±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carbonyl chloride 、 (2-Hydroxy)propylimidazole 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以133.6 mg的产率得到1-(1H-imidazol-2-yl)propan-2-yl 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylate
  参考文献：
  名称：

  [EN] TRANSTHYRETIN STABILIZING COMPOUNDS
  [FR] COMPOSÉS STABILISATEURS DE TRANSTHYRÉTINE

  摘要：

  Provided herein are compounds having activity against TTR related conditions, and pharmaceutically accepted salts and solvates thereof. Also provided are methods of using the compounds for inhibiting and preventing TTR aggregation and/or amyloid formation in the peripheral nerves, kidney, cardiac tissue, eye and CNS, and of treating a subject with peripheral TTR amyloidosis.

  公开号：

  WO2023009585A2
• 作为产物：
  描述：

  1-(1-trityl-1H-imidazol-2-yl)propan-2-ol 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 生成 (2-Hydroxy)propylimidazole
  参考文献：
  名称：

  [EN] TRANSTHYRETIN STABILIZING COMPOUNDS
  [FR] COMPOSÉS STABILISATEURS DE TRANSTHYRÉTINE

  摘要：

  Provided herein are compounds having activity against TTR related conditions, and pharmaceutically accepted salts and solvates thereof. Also provided are methods of using the compounds for inhibiting and preventing TTR aggregation and/or amyloid formation in the peripheral nerves, kidney, cardiac tissue, eye and CNS, and of treating a subject with peripheral TTR amyloidosis.

  公开号：

  WO2023009585A2

文献信息

• 2-(heterocycloalkylthio)penems
  申请人：Schering Corporation

  公开号：US04690922A1

  公开（公告）日：1987-09-01

  This invention relates to 2-(heterocycloalkylthio)penems wherein the nitrogen of the heterocyclic ring is connected to the alkyl group, and to their use as antibacterial agents.

  本发明涉及2-(杂环烷硫基)青霉烷，其中杂环环的氮原子连接到烷基上，以及它们作为抗菌剂的使用。
• [EN] MERCAPTO-CONTAINING BISANHYDROHEXITOL DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE BISANHYDROHEXITOL CONTENANT DES GROUPES MERCAPTO ET LEURS UTILISATIONS
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2013090138A1

  公开（公告）日：2013-06-20

  Bisanhydrohexitol derivatives having terminal mercapto groups are provided. Additionally, curable compositions that include these mercapto-containing bisanhydrohexitol derivatives, cured compositions prepared from the curable compositions, and articles containing the cured compositions are provided. More specifically, the curable compositions are epoxy-based formulations and the mercapto-containing bisanhydrohexitol derivatives function as curing agents for epoxy resins.

  提供具有末端巯基的双脱水己糖醇衍生物。另外，还提供了包含这些含巯基双脱水己糖醇衍生物的可固化组合物、由可固化组合物制备的固化组合物，以及包含固化组合物的物品。更具体地说，这些可固化组合物是基于环氧的配方，而含巯基的双脱水己糖醇衍生物作为环氧树脂的固化剂。
• [EN] IONIC LIQUIDS CONTAINING SECONDARY HYDROXYL-GROUPS AND A METHOD FOR THEIR PREPARATION<br/>[FR] LIQUIDES IONIQUES CONTENANT DES GROUPES HYDROXYLES SECONDAIRES, ET LEUR METHODE DE PREPARATION
  申请人：UNIV ALABAMA

  公开号：WO2005026179A1

  公开（公告）日：2005-03-24

  The invention provides ionic liquids having a secondary hydroxyl group, and an atom-efficient method for the preparation of these ionic liquids, by epoxidation of a protonated nitrogen- containing organic base (which can optionally be prepared in situ) in the presence of an anion suitable for supporting ionic liquid formation.

  本发明提供了具有次级羟基的离子液体，以及一种原子效率高的方法，用于制备这些离子液体，方法是在适合支持离子液体形成的阴离子存在下，通过氧化剂使质子化的含氮有机碱（可选地在原位制备）发生环氧化反应。
• Polyepoxy compounds having an amide linkage
  申请人：Brennan J. David

  公开号：US20050256277A1

  公开（公告）日：2005-11-17

  The present invention provides compounds that have an amide linkage and at least two epoxy groups. The compounds are preferably aliphatic.

  本发明提供了具有酰胺键和至少两个环氧基团的化合物。这些化合物最好是脂肪族的。
• Preparation of phosphorothioate oligomers
  申请人：McGill University

  公开号：US20040097722A9

  公开（公告）日：2004-05-20

  Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.

  本发明揭示了制备含有对映异构富集的磷酸硫酯键寡聚物的方法和中间体。