Boc-Lys-OMe acetate | 136832-75-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Lys-OMe acetate
• 英文别名: Boc-Lys-OMe acetate salt；acetic acid;methyl (2S)-6-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate
• CAS: 136832-75-2
• 化学式: C₂H₄O₂*C₁₂H₂₄N₂O₄
• 分子量: 320.386
• InChiKey: IQQHZKIYBAMWEX-FVGYRXGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.27
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  128
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Boc-Lys-OMe acetate 在 sodium hydroxide 、 三乙胺 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 17.25h， 生成 Boc-Lys(Trt)-OH
  参考文献：
  名称：

  Probing the functional conformation of neuropeptide Y through the design and study of cyclic analogs

  摘要：

  The functional importance of the PP-fold conformation in neuropeptide Y (NPY) was investigated. NPY and N(alpha)-Ac-NPY(10-36), and corresponding cyclic analogues cyclo18,22-[Lys18,Asp22]-NPY and N(alpha)-Ac-cyclo18,22-[Lys18,Asp22]-NPY(10-36), were synthesized. Strategies for synthesis of the cyclic analogues included the use of the Kaiser oxime resin and a segment condensation approach. Circular dichroism studies in phosphate buffer, pH 5.0, indicated self-association of all four peptides at low micromolar concentrations. Monomeric N(alpha)-Ac-NPY(10-36) showed only 13% alpha-helix, compared to 32% alpha-helix for monomeric NPY, demonstrating a helix-stabilizing effect of residues 1-9 that is consistent with the PP fold. The [Lys18,Lys22] lactam bridge stabilized the helical conformation in N(alpha)-Ac-NPY(10-36) (51% alpha-helix), but was helix destabilizing in NPY (21% alpha-helix). In rat brain receptor binding assays, the cyclic and linear N(alpha)-Ac-NPY(10-36) analogues were equipotent (IC50 = 13 nM for I-125-BH-NPY displacement), although the cyclic analogue was twice as potent in rat vas deferens assays. NPY was more potent than its cyclic analogue in the brain receptor binding assays (IC50 = 0.07 and 0.25 nM, respectively), but these peptides were equipotent in the vas deferens assays. These results support a functional role for the PP fold in NPY and correlate with the solution conformations of the monomeric peptides.

  DOI：

  10.1021/jm00084a021
• 作为产物：
  描述：

  N6-((苄氧基)羰基)-N2-(叔丁氧基羰基)-L-赖氨酸甲酯 、 溶剂黄146 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 0.75h， 生成 Boc-Lys-OMe acetate
  参考文献：
  名称：

  Synthesis of hypusine and other polyamines using dibenzyltriazones for amino protection

  摘要：

  The use of 1,3-dibenzyl-5-substituted-hexahydro-2-oxo-1,3,5-triazine ("dibenzyltriazone") as a protecting group for primary amino is described. Optimized conditions for formation and hydrolysis of dibenzyltriazones, as well as a variety of transformations (reduction, oxidation, hydroxyl modification, C-C bond formation) compatible with this protecting group, are presented. N-Protected amino aldehydes such as 46, 47, and 94 are particularly valuable building blocks, as demonstrated by the syntheses of hypusine (86), deoxyhypusine (85), spermidine (74), and two unsaturated spermidine analogues 81 and 84.

  DOI：

  10.1021/jo00049a036

文献信息

• Immunoproteasome Inhibitor–Doxorubicin Conjugates Target Multiple Myeloma Cells and Release Doxorubicin upon Low-Dose Photon Irradiation
  作者：Elmer Maurits、Michel J. van de Graaff、Santina Maiorana、Dennis P. A. Wander、Patrick M. Dekker、Sabina Y. van der Zanden、Bogdan I. Florea、Jacques J. C. Neefjes、Herman S. Overkleeft、Sander I. van Kasteren

  DOI：10.1021/jacs.9b11969

  日期：2020.4.22

  are anthracyclines such as doxorubicin. We here present a new drug targeting approach that combines both drug classes into a single molecule. Doxorubicin was conjugated to an immunoproteasome-selective inhibitor via light-cleavable linkers, yielding peptide epoxyketone–doxorubicin prodrugs that remained selective and active toward immunoproteasomes. Upon cellular uptake and immunoproteasome inhibition

  蛋白酶体抑制剂是治疗血液系统癌症的公认治疗剂，蒽环类药物如阿霉素也是如此。我们在这里提出了一种新的药物靶向方法，它将两种药物类别结合到一个分子中。多柔比星通过光可裂解接头与免疫蛋白酶体选择性抑制剂偶联，产生肽环氧基酮-多柔比星前药，该前药对免疫蛋白酶体保持选择性和活性。在细胞摄取和免疫蛋白酶体抑制后，多柔比星通过光照射从免疫蛋白酶体抑制剂中释放出来。多发性骨髓瘤细胞以这种方式受到双重打击：免疫蛋白酶体抑制和阿霉素诱导的毒性。我们的策略需要靶向细胞毒剂，
• [EN] BIOSYNTHETICALLY GENERATED PYRROLINE-CARBOXY-LYSINE AND SITE SPECIFIC PROTEIN MODIFICATIONS VIA CHEMICAL DERIVATIZATION OF PYRROLINE-CARBOXY-LYSINE AND PYRROLYSINE RESIDUES<br/>[FR] PYRROLINE-CARBOXY-LYSINE PRODUITE PAR BIOSYNTHÈSE ET MODIFICATIONS DE PROTÉINES SPÉCIFIQUES DE SITE OBTENUES PAR UNE DÉRIVATISATION CHIMIQUE DE PYRROLINE-CARBOXY-LYSINE ET DE RÉSIDUS DE PYRROLYSINE
  申请人：IRM LLC

  公开号：WO2010048582A1

  公开（公告）日：2010-04-29

  Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and peptides that have PCL incorporated therein and methods for incorporating PCL into such proteins, polypeptides and peptides. Also disclosed herein is the site-specific derivatization of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. Also disclosed herein is the crosslinking of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein.

  本文披露了吡咯酮羧基赖氨酸（PCL），一种吡咯赖氨酸类似物，它是一种天然的、生物合成产生的氨基酸，以及生物合成生成PCL的方法。本文还披露了含有PCL的蛋白质、多肽和肽以及将PCL纳入这些蛋白质、多肽和肽中的方法。本文还披露了具有PCL或吡咯赖氨酸的蛋白质、多肽和肽的特定位点衍生化。本文还披露了具有PCL或吡咯赖氨酸的蛋白质、多肽和肽的交联。
• Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides
  作者：Rupert S. J. Proctor、Padon Chuentragool、Avene C. Colgan、Robert J. Phipps

  DOI：10.1021/jacs.1c01556

  日期：2021.4.7

  formed stereocenter as well as site selectivity on both the heteroarene and the amide. This is achieved by the use of a chiral phosphoric acid catalyst in conjunction with diacetyl as a combined hydrogen atom transfer reagent and oxidant. Diacetyl is directly photoexcitable, and thus, no extraneous photocatalyst is required: an added feature that contributes to the simplicity and practicality of the

  Minisci型反应是围绕基本杂芳烃构建复杂性的最强大方法之一。最理想的变体涉及每个伙伴上 C-H 键的正式氧化偶联，从而得到最简单的起始材料。我们在此公开了一种方法，该方法能够实现线性酰胺和杂芳烃的这种偶联，并完全控制新形成的立构中心处的对映选择性以及杂芳烃和酰胺两者上的位点选择性。这是通过使用手性磷酸催化剂与联乙酰作为组合的氢原子转移试剂和氧化剂来实现的。二乙酰可直接光激发，因此不需要额外的光催化剂：这一附加功能有助于该方案的简单性和实用性。
• A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition
  作者：Nicholas Favalli、Stefan Biendl、Marco Hartmann、Jacopo Piazzi、Filippo Sladojevich、Susanne Gräslund、Peter J. Brown、Katja Näreoja、Herwig Schüler、Jörg Scheuermann、Raphael Franzini、Dario Neri

  DOI：10.1002/cmdc.201800193

  日期：2018.7.6

  A DNA‐encoded chemical library (DECL) with 1.2 million compounds was synthesized by combinatorial reaction of seven central scaffolds with two sets of 343×492 building blocks. Library screening by affinity capture revealed that for some target proteins, the chemical nature of building blocks dominated the selection results, whereas for other proteins, the central scaffold also crucially contributed

  通过七个中央支架与两组 343×492 构建块的组合反应，合成了一个包含 120 万种化合物的 DNA 编码化学文库 (DECL)。通过亲和力捕获进行的文库筛选表明，对于某些靶蛋白，构建块的化学性质主导了选择结果，而对于其他蛋白质，中心支架也对配体亲和力至关重要。发现基于 3,5-双（氨基甲基）苯甲酸核心结构的分子与人血清白蛋白结合的K d值为 6 nm ，而在等距但灵活的 L-赖氨酸支架上具有相同取代基的化合物显示140 - 降低亲和力。18 nm tankyrase-1 粘合剂具有特色l赖氨酸作为连接部分，而基于d-赖氨酸或 (2 S ,4 S )-氨基- l-脯氨酸的分子与靶标没有可检测到的结合。这项工作表明，使化学结构单元朝向蛋白质靶标的方向易于定位的中央支架可以提高编码文库的筛选效率。
• Synthesis of the reported structure of the naturally occurring siderophore nocardimicin B
  作者：James C. Banks、Christopher J. Moody

  DOI：10.1016/j.tetlet.2009.02.124

  日期：2009.7

  A total synthesis of the reported structure of the naturally occurring siderophore nocardimicin B is reported: the synthetic material appears to be diastereomeric with the natural product.

  据报道，天然存在的铁载体诺卡霉素B的结构已完全合成：合成材料似乎与天然产物是非对映异构的。