(1RS,5SR,6RS)-6-methylbicyclo[3.1.0]hexan-6-ol | 60153-77-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1RS,5SR,6RS)-6-methylbicyclo[3.1.0]hexan-6-ol
• CAS: 60153-77-7
• 化学式: C₇H₁₂O
• 分子量: 112.172
• InChiKey: AVFQYBXWEJXWJL-ZMONIFLSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.17
• 重原子数：
  8.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  6-(benzyloxy)hex-3-enyl ethanoate 在 METHYLTITANIUM TRIISOPROPOXIDE 、 Cyclopentylmagnesium chloride 作用下， 以 乙醚 为溶剂， 反应 0.33h， 以91%的产率得到6-(benzyloxy)hex-3-en-1-ol
  参考文献：
  名称：

  Intramolecular Kulinkovich–de Meijere reactions of various disubstituted alkenes bearing amide groups

  摘要：

  A range of amides fitted with (E) or (Z) disubstituted alkene groups were prepared and evaluated in intramolecular Kulinkovich-de Meijere reactions. The corresponding aminocyclopropanes were obtained with high diastereoselectivity. Good yields could be achieved with substrates bearing suitable substitutions at the olefin moieties. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.06.067

文献信息

• Intramolecular Kulinkovich–de Meijere reactions of various disubstituted alkenes bearing amide groups
  作者：Claire Madelaine、Nouara Ouhamou、Angèle Chiaroni、Emeline Vedrenne、Laurence Grimaud、Yvan Six

  DOI：10.1016/j.tet.2008.06.067

  日期：2008.9

  A range of amides fitted with (E) or (Z) disubstituted alkene groups were prepared and evaluated in intramolecular Kulinkovich-de Meijere reactions. The corresponding aminocyclopropanes were obtained with high diastereoselectivity. Good yields could be achieved with substrates bearing suitable substitutions at the olefin moieties. (C) 2008 Elsevier Ltd. All rights reserved.