2-methoxy-4-acetoxy-6-methyl pyrimidine | 100936-10-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methoxy-4-acetoxy-6-methyl pyrimidine
• 英文别名: 2-Methoxy-6-methyl-4-pyrimidinyl acetate；(2-methoxy-6-methylpyrimidin-4-yl) acetate
• CAS: 100936-10-5
• 化学式: C₈H₁₀N₂O₃
• 分子量: 182.179
• InChiKey: LLIBHMVCSPALMG-UHFFFAOYSA-N

物化性质

• 熔点：
  121-122 °C(Solv: chloroform (67-66-3))
• 沸点：
  299.0±32.0 °C(Predicted)
• 密度：
  1.184±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  61.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-methoxy-4-acetoxy-6-methyl pyrimidine 、 正丁醇 以10%的产率得到乙酸丁酯
  参考文献：
  名称：

  嘧啶转化中的6-烷基-2-乙氧基-4-（3h）-嘧啶酮：4-酰化嘧啶衍生物的区域特异性制备，抗肿瘤和抗菌活性。胺选择性酰化的新剂

  摘要：

  提出了4-酰化吡咯烷基的高产率合成。这些产品是胺酰基乙酰胺的选择性试剂。抗肿瘤和化合物的抗微生物活性和还报道。

  DOI：

  10.1016/0040-4039(88)85275-4
• 作为产物：
  描述：

  6-methyl-2-methoxy-4-O-piperonylpyrimidine 在 吡啶 作用下， 以 乙腈 为溶剂， 反应 24.0h， 生成 2-methoxy-4-acetoxy-6-methyl pyrimidine
  参考文献：
  名称：

  Researches on antiviral agents. 4. Studies on the chemistry of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives as new acylation reagents and inhibitors of uracil DNA glycosylases.

  摘要：

  The synthesis of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives 2 and 5 along with their properties as acylating agents of amines, alcohols, thiols and alpha-amino acids have been reported. Interestingly some of the tide products revealed an inhibitory activity against the human and herpetic DNA glycosylases.

  DOI：

  10.1016/s0040-4020(01)87037-x

文献信息

• 6-alkyl- and 5,6-dialkyl-2-methoxy-4(3H)-pyrimidinones in the transformations of pyrimidines. Regiospecific 1--acylation of pyrimidines.
  作者：Maurizio Botta、Francesco De Angelis、Gabriella Finizia、Rosario Nicoletti、Maurizio Delfini

  DOI：10.1016/s0040-4039(00)98294-7

  日期：1985.1
• Botta Maurizio, Saladino Raffaele, Gentile Gabriella, Summa Vincenzo, Nic+, Tetrahedron, 50 (1994) N 11, S 3603-3618
  作者：Botta Maurizio, Saladino Raffaele, Gentile Gabriella, Summa Vincenzo, Nic+

  DOI：——

  日期：——
• BOTTA, MAURIZIO;DE, ANGELIS FRANCESCO;NICOLETTI, ROSARIO, TETRAHEDRON LETT., 29,(1988) N 22, 2741-2744
  作者：BOTTA, MAURIZIO、DE, ANGELIS FRANCESCO、NICOLETTI, ROSARIO

  DOI：——

  日期：——
• Researches on antiviral agents. 4. Studies on the chemistry of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives as new acylation reagents and inhibitors of uracil DNA glycosylases.
  作者：Maurizio Botta、Raffaele Saladino、Gabriella Gentile、Vincenzo Summa、Rosario Nicoletti、Annalisa Verri、Federico Focher、Silvio Spadari

  DOI：10.1016/s0040-4020(01)87037-x

  日期：1994.3

  The synthesis of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives 2 and 5 along with their properties as acylating agents of amines, alcohols, thiols and alpha-amino acids have been reported. Interestingly some of the tide products revealed an inhibitory activity against the human and herpetic DNA glycosylases.
• 6-alkyl-2-hethoxy-4-(3h)-pyrimidinones in the transformation of pyrimidines: regiospecific preparation, antitumor and antimicrobial activity of 4-O-acylated pyrimidine derivatives. New agents for selective acylation of amines
  作者：Maurizio Botta、Francesco De Angelis、Rosarlo Nicoletti、Alessandra Pani、Maria Elena Marongiu、Paolo La Colla

  DOI：10.1016/0040-4039(88)85275-4

  日期：——

  A high yielding synthesis of 4--acylated pyrlmldines is presented. These products are selective reagents for amine acylatlon. The antitumor and antimicrobial activity of compounds and is also reported.

  提出了4-酰化吡咯烷基的高产率合成。这些产品是胺酰基乙酰胺的选择性试剂。抗肿瘤和化合物的抗微生物活性和还报道。