5-Methoxy-2-methylpent-1-en-3-one | 136491-97-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Methoxy-2-methylpent-1-en-3-one
• CAS: 136491-97-9
• 化学式: C₇H₁₂O₂
• 分子量: 128.171
• InChiKey: KNOKLWFMPSMQCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-Methoxy-2-methylpent-1-en-3-one 、 甲胺 以20%的产率得到
  参考文献：
  名称：

  MAKIN, S. M.;NAZAROVA, O. N.;KUNDRYUTSKOVA, L. A.;DYMSHAKOVA, G. M.;ARSHA+, ZH. ORGAN. XIMII, 27,(1991) N, S. 312-317

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-1-丁烯-3-酮 在 三乙胺 、 乙腈 、 sodium iodide 、 zinc dibromide 作用下， 反应 2.0h， 生成 5-Methoxy-2-methylpent-1-en-3-one
  参考文献：
  名称：

  Makin, S.M.; Nazarowa, O.N.; Kundryutskova, L.A., Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 2, p. 265 - 269

  摘要：

  DOI：

文献信息

• [EN] MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS DE SUBSTANCES ANALOGUES A LA MIGRASTATINE ET LEURS UTILISATIONS
  申请人：CORNELL RES FOUNDATION INC

  公开号：WO2004087672A1

  公开（公告）日：2004-10-14

  In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-RC, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.

  在一方面，本发明提供了包含式(I)化合物的治疗有效量的药物组合物，其中R1-R6，Ra-RC，Q，Y1，Y2和n如本文所述定义，该组合物为用于向受试者给药而配制成，剂量为约0.1 mg/kg至约50 mg/kg体重。在另一方面，本发明提供了一种治疗受试者乳腺癌转移的方法，包括向需要治疗的受试者给药治疗有效量的上述创新组合物以及药用可接受载体、佐剂或车辆。
• EP1613603A2
  申请人：——

  公开号：EP1613603A2

  公开（公告）日：2006-01-11
• MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF
  申请人：CORNELL RESEARCH FOUNDATION, INC.

  公开号：EP1608626A1

  公开（公告）日：2005-12-28
• Medical device, materials, and methods
  申请人：Rolland P. Jason

  公开号：US20070178133A1

  公开（公告）日：2007-08-02

  Dual thermal and photo curable materials are used for fabricating, functionalizing, and utilizing devices, such as medical devices, surgical devices, and medical implants. The materials include thermal and photo curable components that can adhere layers of the materials to one another, to other substrates, or to biologic tissues to form medical devices, surgical devices, and medical implants.
• METHODS AND MATERIALS FOR FABRICATING MICROFLUIDIC DEVICES
  申请人：DeSimone Joseph M.

  公开号：US20090281250A1

  公开（公告）日：2009-11-12

  Materials and Methods are provided for fabricating microfluidic devices. The materials include low surface energy fluoropolymer compositions having multiple cure functional groups. The materials can include multiple photocurable and/or thermal-curable functional groups such that laminate devices can be fabricated. The materials also substantially do not swell in the presence of hydrocarbon solvents.