hexadecyl L-glutaminate | 929697-36-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: hexadecyl L-glutaminate
• 英文别名: hexadecyl (2S)-2,5-diamino-5-oxopentanoate
• CAS: 929697-36-9
• 化学式: C₂₁H₄₂N₂O₃
• 分子量: 370.576
• InChiKey: CEKWVRVBTJXVLX-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  26
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  95.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  hexadecyl L-glutaminate 在 potassium hydrogencarbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 11.0h， 生成 hexadecyl N-(lysyl)glutaminate bis(trifluoroacetate)
  参考文献：
  名称：

  pH-sensitive cationic lipopeptides for the design of drug-delivery systems

  摘要：

  Lipopeptides on the basis of L-glutamic acid and glutamine di- and monoesters with aliphatic alcohols of various lengths that contain L-arginine, L-ornithine, and L-lysine were synthesized. The behavior of these amphiphiles in aqueous medium was shown to depend on their structure.

  DOI：

  10.1134/s1068162006050025
• 作为产物：
  描述：

  L-谷氨酰胺 、 1-十六烷醇 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以61%的产率得到hexadecyl L-glutaminate
  参考文献：
  名称：

  pH-sensitive cationic lipopeptides for the design of drug-delivery systems

  摘要：

  Lipopeptides on the basis of L-glutamic acid and glutamine di- and monoesters with aliphatic alcohols of various lengths that contain L-arginine, L-ornithine, and L-lysine were synthesized. The behavior of these amphiphiles in aqueous medium was shown to depend on their structure.

  DOI：

  10.1134/s1068162006050025

文献信息

• CYANOPHOSPHONAMIDES AND METHOD FOR PREPARATION
  申请人：Monsanto Technology LLC

  公开号：EP1135398A1

  公开（公告）日：2001-09-26
• US6218563B1
  申请人：——

  公开号：US6218563B1

  公开（公告）日：2001-04-17
• [EN] CYANOPHOSPHONAMIDES AND METHOD FOR PREPARATION<br/>[FR] CYANOPHOSPHONAMIDES ET LEUR PROCEDE DE PREPARATION
  申请人：MONSANTO CO

  公开号：WO2000032611A1

  公开（公告）日：2000-06-08

  The present invention provides a process for preparing a cyanophosphonamide comprising contacting phosphoric anhydride and a cyanide, preferably in the presence of a Lewis base, to produce a cyanophosphonate intermediate, and subsequently contacting the cyanophosphonate intermediate with an amino compound.
• pH-sensitive cationic lipopeptides for the design of drug-delivery systems
  作者：Yu. L. Sebyakin、U. A. Budanova

  DOI：10.1134/s1068162006050025

  日期：2006.9

  Lipopeptides on the basis of L-glutamic acid and glutamine di- and monoesters with aliphatic alcohols of various lengths that contain L-arginine, L-ornithine, and L-lysine were synthesized. The behavior of these amphiphiles in aqueous medium was shown to depend on their structure.