{2-[2-(2,5-Dioxo-pyrrolidin-1-yloxycarbonylmethoxy)-ethoxy]-ethoxy}-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester | 211746-81-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: {2-[2-(2,5-Dioxo-pyrrolidin-1-yloxycarbonylmethoxy)-ethoxy]-ethoxy}-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester
• 英文别名: Bis(2,5-dioxopyrrolidin-1-yl) 2,2'-((oxybis(ethane-2,1-diyl))bis(oxy))diacetate；(2,5-dioxopyrrolidin-1-yl) 2-[2-[2-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethoxy]ethoxy]ethoxy]acetate
• CAS: 211746-81-5
• 化学式: C₁₆H₂₀N₂O₁₁
• 分子量: 416.342
• InChiKey: WNIVQJOYZVESBG-UHFFFAOYSA-N

物化性质

• 沸点：
  549.8±60.0 °C(Predicted)
• 密度：
  1.48±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  29
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  155
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  {2-[2-(2,5-Dioxo-pyrrolidin-1-yloxycarbonylmethoxy)-ethoxy]-ethoxy}-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester 在 10 wt% Pd(OH)2 on carbon 、 氢气 、 溶剂黄146 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 7.0h， 生成 8-[[2-[2-[2-[2-(7-Carboxyheptylamino)-2-oxoethoxy]ethoxy]ethoxy]acetyl]amino]octanoic acid
  参考文献：
  名称：

  [EN] DENDRITIC CORE COMPOUNDS
  [FR] COMPOSÉS À CŒUR DENDRITIQUE

  摘要：

  本发明涉及用于制备树枝状化合物有用的化合物，以及使用这些化合物来制备树枝状化合物的方法以及制备这些化合物的过程。

  公开号：

  WO2014084743A1
• 作为产物：
  描述：

  3,6,9-三噁十一烷二酸 在 吡啶 、 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 {2-[2-(2,5-Dioxo-pyrrolidin-1-yloxycarbonylmethoxy)-ethoxy]-ethoxy}-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester
  参考文献：
  名称：

  Ligand Recognition by E- and P-Selectin:  Chemoenzymatic Synthesis and Inhibitory Activity of Bivalent Sialyl Lewis x Derivatives and Sialyl Lewis x Carboxylic Acids

  摘要：

  Described is the preparation of five sLe(x) dimers and five sLe(x) carboxylic acids by coupling chemoenzymatically synthesized amino-substituted sialyl Lewis x (sLe(x)) derivative 4 to homobifunctional cross-linkers 20-24 of varying chain length. 20-24 were obtained by alkylating low-molecular-weight oligoethylene glycols with tert-butyl bromoacetate and subsequent transformation of the di-tert-butyl esters into disuccinimide esters. The products were assayed for inhibition against binding of a sLe(a)-polymer to immobilized E- and P-selectin. In the E-selectin assay all dimers had lower IC50 values than the sLex monomer. The results show that comparable binding enhancements can be obtained with linkers of completely different length and rigidity. In the P-selectin assay four of the five sLe(x) carboxylic acids displayed significantly improved inhibitory potency. The lowest IC50 value was observed for the compound with the shortest spacer between the sLex moiety and the additional carboxylate, being ca. 20-40 times more potent than unmodified sLex. These findings should be of importance for the design of new multivalent forms of sLe(x) as well as sLe(x) mimetics as high-affinity selectin ligands.

  DOI：

  10.1021/jo980350s

文献信息

• [EN] HEPARAN SULFATE GLYCOMIMETIC COMPOUNDS AND THEIR PHARMACEUTICAL AND COSMECEUTICAL USES<br/>[FR] COMPOSÉS GLYCOMIMÉTIQUES DE SULFATE D'HÉPARANE ET LEURS UTILISATIONS PHARMACEUTIQUES ET COSMÉTIQUES
  申请人：VICTORIA LINK LTD

  公开号：WO2018174725A1

  公开（公告）日：2018-09-27

  The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical and cosmeceutical compositions containing the compounds, and methods of treating cancer, inflammation, diabetic nephropathy, neurodegenerative disorders, Niemann-Pick Type C disease, or dermatological conditions.

  该发明涉及树枝状化合物，这些化合物作为药物的使用，包含这些化合物的药物和美容药物组合物，以及治疗癌症、炎症、糖尿病肾病、神经退行性疾病、尼曼-皮克病C型或皮肤病学状况的方法。
• ONE POT ELECTRO-CROSS-LINKING OF A PROTEIN FOR THE DEVELOPMENT OF A PROTEIN-BASED BIOSENSOR
  申请人：Centre National De La Recherche Scientifique

  公开号：US20210010050A1

  公开（公告）日：2021-01-14

  Disclosed is a liquid composition including a protein, a polyphenol and a morphogen; to a solid composition including the cross-linked product of a protein and a polyphenol; to a biosensor and a biofuel cell including the solid composition bound to a surface of an electrochemical probe; to a process for the detection of an analyte with the biosensor; and to the use of a ferrocene as a morphogen in an electrodeposition process.

  披露了一种液体组合物，包括蛋白质、多酚和形态素；一种固体组合物，包括蛋白质与多酚的交联产物；一种生物传感器和生物燃料电池，包括将固体组合物绑定在电化学探针的表面；一种使用生物传感器检测分析物的方法；以及在使用ferrocene作为形态素在电镀过程中的用途。
• Heparan sulfate glycomimetic compounds and their pharmaceutical and cosmeceutical uses
  申请人：VICTORIA LINK LIMITED

  公开号：US11186603B2

  公开（公告）日：2021-11-30

  The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical and cosmeceutical compositions containing the compounds, and methods of treating cancer, inflammation, diabetic nephropathy, neurodegenerative disorders, Niemann-Pick Type C disease, or dermatological conditions.

  本发明涉及树枝状化合物、这些化合物作为药物的用途、含有这些化合物的药物和药妆组合物，以及治疗癌症、炎症、糖尿病肾病、神经退行性疾病、尼曼镰状细胞病 C 型或皮肤病的方法。
• DENDRITIC CORE COMPOUNDS
  申请人：VICTORIA LINK LIMITED

  公开号：US20150291522A1

  公开（公告）日：2015-10-15

  The invention relates to compounds that are useful for the preparation of dendrimer compounds, the use of these compounds for preparing dendrimers and processes for preparing the compounds.
• Saccharide Dendritic Cluster Compounds as Inhibitors of Bace-1
  申请人：VICTORIA LINK LIMITED

  公开号：US20150291644A1

  公开（公告）日：2015-10-15

  The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical compositions containing the compounds, processes for preparing the compounds, and methods of treating diseases or conditions in which it is desirable to inhibit β-secretase.