ethyl 2-hydroxy-2-methyl-4-oxo-4-phenylbutanoate | 57146-97-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 2-hydroxy-2-methyl-4-oxo-4-phenylbutanoate
• CAS: 57146-97-1
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: IGWZXLBFEFTLAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 2-hydroxy-2-methyl-4-phenyl-but-3-ynoate 在 mercury(II) diacetate 作用下， 以 甲酸 、 溶剂黄146 为溶剂， 生成 ethyl 2-hydroxy-2-methyl-4-oxo-4-phenylbutanoate
  参考文献：
  名称：

  Synthesis of 3-Unsubstituted 2-Hydroxy-4-oxoalkanoates

  摘要：

  DOI：

  10.1055/s-1976-24229

文献信息

• NEW CROSS ALDOL REACTIONS. THE REACTIONS OF SILYL ENOL ETHERS WITH KETO ESTERS PROMOTED BY TITANIUM TETRACHLORIDE
  作者：Kazuo Banno、Teruaki Mukaiyama

  DOI：10.1246/cl.1975.741

  日期：1975.7.5

  It was found that, in the presence of TiCl4, keto esters such as ethyl pyruvate, ethyl 2,2-dimethyl acetoacetate, ethyl levulinate and ethyl 5-oxohexanoate react with various trimethylsilyl enol ethers derived from ketones at room temperature to afford cross aldols, i.e., hydroxy keto esters, in good yields.

  发现在 TiCl4 存在下，酮酯如丙酮酸乙酯、2,2-二甲基乙酰乙酸乙酯、乙酰丙酸乙酯和 5-氧代己酸乙酯在室温下与各种衍生自酮的三甲基甲硅烷基烯醇醚反应，得到交叉醛醇，即羟基酮酯，产率良好。
• Aldol-Type Reaction of<i>α</i>-Halo Ketones with<i>α</i>-Ketocarboxylates Mediated by SmI₂or SmI₃: Facile Synthesis of<i>α</i>-Hydroxy-<i>γ</i>-ketocarboxylates
  作者：Tsutomu Arime、Naoki Kato、Fumio Komadate、Hiroko Saegusa、Nobuo Mori

  DOI：10.1080/00397919408010255

  日期：1994.12

  Abstract The title reaction smoothly proceeds at room temperature to give α-hydroxy-γ-keto esters 3 in good yields, probably via a mechanism involving samarium enolates formed in situ from α-halo ketones.

  摘要 标题反应在室温下顺利进行，以良好的产率得到 α-羟基-γ-酮酯 3，这可能是通过 α-卤代酮原位形成钐烯醇化物的机制。
• Functionalized S-perfluorinated sulfoximines: Preparation and evaluation in catalytic processes
  作者：Thanh-Nghi Le、Patrick Diter、Bruce Pégot、Chloée Bournaud、Martial Toffano、Regis Guillot、Giang Vo-Thanh、Yurii Yagupolskii、Emmanuel Magnier

  DOI：10.1016/j.jfluchem.2015.06.020

  日期：2015.11

  N-substituted S-perfluoroalkylated sulfoximines were synthesized from the NH sulfoximines either by a copper coupling reaction with aryl halides or by a reaction with electrophilic substrates. The procedure allowed the preparation of N,N'-bridged bis sulfoximines and of thioureas. The potential of these new sulfoximines was evaluated in different catalytic processes. (C) 2015 Elsevier B.V. All rights reserved.