6-deoxy-D-altrose | 643-18-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-deoxy-D-altrose
• 英文别名: D-6-deoxy-altrose；6-Desoxy-D-altrose；D-altromethylose；(3S,4R,5S,6R)-6-methyloxane-2,3,4,5-tetrol
• CAS: 643-18-5
• 化学式: C₆H₁₂O₅
• 分子量: 164.158
• InChiKey: SHZGCJCMOBCMKK-RSVSWTKNSA-N

物化性质

• 沸点：
  323.9±42.0 °C(Predicted)
• 密度：
  1.556±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-deoxy-D-altrose 在 sodium tetrahydroborate 作用下， 以 水 为溶剂， 反应 15.0h， 生成 6-脱氧阿卓糖醇
  参考文献：
  名称：

  Characterization of 6-deoxy-d-altritol in the cell-wall polysaccharide of Nocardia asteroides R 399

  摘要：

  A polyol, found in the cell-wall of Nocardia asteroides R 399 as a component of a neutral polysaccharide mainly composed of D-arabinose and D-galactose, was identified by mass spectrometry, paper chromatography, thin-layer chromatography, and gas chromatography as 6-deoxy-D-altritol.

  DOI：

  10.1016/s0008-6215(00)90459-2
• 作为产物：
  描述：

  a-L-阿卓吡喃糖 在 镍 盐酸 、 四碘甲烷 、 氢气 、 三苯基膦 作用下， 以 吡啶 、 甲醇 为溶剂， 反应 45.0h， 生成 6-deoxy-D-altrose
  参考文献：
  名称：

  Characterization of 6-deoxy-d-altritol in the cell-wall polysaccharide of Nocardia asteroides R 399

  摘要：

  A polyol, found in the cell-wall of Nocardia asteroides R 399 as a component of a neutral polysaccharide mainly composed of D-arabinose and D-galactose, was identified by mass spectrometry, paper chromatography, thin-layer chromatography, and gas chromatography as 6-deoxy-D-altritol.

  DOI：

  10.1016/s0008-6215(00)90459-2

文献信息

• Pharmaceutical compositions having appetite suppressant activity
  申请人：CSIR

  公开号：US20020168427A1

  公开（公告）日：2002-11-14

  A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1) and its analogues and derivatives is also provided. The invention also extends to the use of such extracts and compound (1) and its analogues for the manufacture of medicaments having appetite suppressant activity. The invention further provides novel intermediates for the synthesis of compound (1).

  一种药物组合物包含可从Trichocaulon或Hoodia属植物中获得的提取物，其中包含具有式（1）的食欲抑制剂。还提供了获得该提取物的过程以及合成化合物（1）及其类似物和衍生物的过程。该发明还扩展到利用这些提取物和化合物（1）及其类似物制造具有食欲抑制活性的药物。该发明还提供了合成化合物（1）的新型中间体。
• Use of extracts from Hoodia gordonii and Hoodia lugardii for the preparation of a medicament for use in the suppression of appetite
  申请人：CSIR

  公开号：EP1438965A1

  公开（公告）日：2004-07-21

  Extracts obtainable from Hoodia gordonii or lugardii containing an appetite suppressant agent having the formula (1) are disclosed for the manufacture of medicaments having appetite suppressant activity.

  公开了从 Hoodia gordonii 或 lugardii 中提取的含有式（1）食欲抑制剂的提取物，用于制造具有食欲抑制活性的药物。
• Method of suppressing appetite
  申请人：CSIR

  公开号：EP1598054A2

  公开（公告）日：2005-11-23

  A non-therapeutic method of suppressing appetite in a human or animal comprises administering to the said human or animal a composition, for example a foodstuff or beverage, comprising an extract from a plant of the genus Trichocaulon or the genus Hoodia, which extract contains an effective amount of an appetite-suppressant steroidal glycoside from said plant, wherein the steroidal glycoside has the formula

  一种抑制人或动物食欲的非治疗方法，包括向所述人或动物施用一种组合物，例如一种食品或饮料，该组合物包含来自毛果芸香属或茄属植物的提取物，该提取物包含有效量的来自所述植物的抑制食欲的甾体苷，其中所述甾体苷的式为
• DOGANCA, S.;ULUBELEN, A.;TUZLACI, E., PHYTOCHEMISTRY, 28,(1989) N2, C. 3561-3562
  作者：DOGANCA, S.、ULUBELEN, A.、TUZLACI, E.

  DOI：——

  日期：——
• BOCK, KLAUS;GUZMAN, FERNANDEZ-BOLANOS;NORRESTAM, ROLF, CARBOHYDR. RES., 179,(1988) C. 97-124
  作者：BOCK, KLAUS、GUZMAN, FERNANDEZ-BOLANOS、NORRESTAM, ROLF

  DOI：——

  日期：——