6-amino-3-bromo-2H-chromen-2-one | 405916-09-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 6-amino-3-bromo-2H-chromen-2-one
• 英文别名: 6-amino-3-bromocoumarin；6-Amino-3-brom-cumarin；6-Amino-3-bromochromen-2-one
• CAS: 405916-09-8
• 化学式: C₉H₆BrNO₂
• 分子量: 240.056
• InChiKey: DUQYVYLXEQVZNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-amino-3-bromo-2H-chromen-2-one 在 盐酸 、 氯化亚砜 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 11.0h， 生成 methyl 2-(8-bromo-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)acetate
  参考文献：
  名称：

  Syntheses and characterizations of novel pyrrolocoumarin probes for SNAP-tag labeling technology

  摘要：

  SNAP-tag technology is a revolutionary protein labeling technology employing in various biological studies. Since low signal/noise ratio and severe overlap between the FRET donors/acceptors often occurred in applying present fluorescent probes and thus limited the further applications, development of new fluorescent probes with excellent fluorescent properties is still of request by today's SNAP-tag technology. In this paper, a number of SNAP-tag protein probes have been developed by incorporating a novel pyrrolocoumarin fluorophore recently developed by our group. Examination of these novel synthetic compounds shows all these materials possess satisfactory fluorescent properties. Among these, probe 7 exhibits the most excellent characters, and its quantum yield, maximum emission wavelength and Stocks shift reach to 0.44, 534 nm and 112 nm, respectively. Further analysis of structure-property relationship indicates that the probes with a longer C3-substituted alkyl (such as pentyl) give stronger fluorescence. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.075
• 作为产物：
  描述：

  3-bromo-6-nitro-2H-chromen-2-one 在 铁粉 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 0.67h， 以98%的产率得到6-amino-3-bromo-2H-chromen-2-one
  参考文献：
  名称：

  开发具有令人满意的荧光特性和显着大斯托克斯位移的新型吡咯香豆素衍生物

  摘要：

  具有大斯托克斯位移和长发射波长的小型有机荧光分子是各种现代荧光成像技术（如 FRET）的理想染料。在这项研究中，我们在两个吡咯香豆素骨架的基本结构上设计并合成了许多新的荧光分子，其中 Fischer 的吲哚合成和 Suzuki 偶联成功地作为有效的分子编辑方案。对这些化合物的荧光特性和进一步结构优化的检查提供了三种具有显着大斯托克斯位移和令人满意的荧光特性的新型吡咯并香豆素染料。其中，30 表现出较大的斯托克斯位移（113 nm）和强烈的荧光（φ = 0.55，λem = 523 nm），因此在生物成像研究中显示出巨大的潜力。(© Wiley-VCH Verlag GmbH & Co.

  DOI：

  10.1002/ejoc.200800883

文献信息

• Direct β-Alkenylation of Ketones via Pd-Catalyzed Redox Cascade
  作者：Chengpeng Wang、Alexander J. Rago、Guangbin Dong

  DOI：10.1021/acs.orglett.9b01116

  日期：2019.5.3

  A direct β-alkenylation of simple ketones with alkenyl bromides is reported via a Pd-catalyzed redox cascade strategy. The reaction is redox neutral and directing-group-free, in the absence of strong acids or bases. Both cyclic and linear ketones are suitable substrates, and various alkenyl bromides can be coupled. The resulting β-alkenyl ketones are readily derivatized through diverse alkene functionalization

  据报道，通过Pd催化的氧化还原级联策略，简单的酮与烯基溴化物直接进行β-烯基化反应。在不存在强酸或强碱的情况下，该反应为氧化还原中性且无导向基团。环状酮和线性酮都是合适的底物，并且各种烯基溴化物可以偶联。所得的β-烯基酮很容易通过各种烯烃官能化作用衍生化。
• Dey; Seshadri, Journal of the Indian Chemical Society, 1926, vol. 3, p. 171
  作者：Dey、Seshadri

  DOI：——

  日期：——
• Single-Compound Libraries of Organic Materials: Parallel Synthesis and Screening of Fluorescent Dyes
  作者：Marc-Steffen Schiedel、Christoph A. Briehn、Peter Bäuerle

  DOI：10.1002/1521-3773(20011217)40:24<4677::aid-anie4677>3.0.co;2-u

  日期：2001.12.17
• Syntheses and characterizations of novel pyrrolocoumarin probes for SNAP-tag labeling technology
  作者：De-Sheng Mei、Yi Qu、Jin-Xiang He、Lei Chen、Zhu-Jun Yao

  DOI：10.1016/j.tet.2011.01.075

  日期：2011.3

  SNAP-tag technology is a revolutionary protein labeling technology employing in various biological studies. Since low signal/noise ratio and severe overlap between the FRET donors/acceptors often occurred in applying present fluorescent probes and thus limited the further applications, development of new fluorescent probes with excellent fluorescent properties is still of request by today's SNAP-tag technology. In this paper, a number of SNAP-tag protein probes have been developed by incorporating a novel pyrrolocoumarin fluorophore recently developed by our group. Examination of these novel synthetic compounds shows all these materials possess satisfactory fluorescent properties. Among these, probe 7 exhibits the most excellent characters, and its quantum yield, maximum emission wavelength and Stocks shift reach to 0.44, 534 nm and 112 nm, respectively. Further analysis of structure-property relationship indicates that the probes with a longer C3-substituted alkyl (such as pentyl) give stronger fluorescence. (C) 2011 Elsevier Ltd. All rights reserved.
• Development of New Pyrrolocoumarin Derivatives with Satisfactory Fluorescent Properties and Notably Large Stokes Shifts
  作者：Lei Chen、Tai-Shan Hu、Zhu-Jun Yao

  DOI：10.1002/ejoc.200800883

  日期：2008.12

  efficient molecular editing protocols. The examination of the fluorescent properties and further structural optimization of these compounds afforded three new pyrrolocoumarin dyes with notably large Stokes shifts and satisfactory fluorescent properties. Among these, 30 showed a large Stokes shift (113 nm) and intense fluorescence (φ = 0.55, λem = 523 nm), and thus showed great potential in biological imaging

  具有大斯托克斯位移和长发射波长的小型有机荧光分子是各种现代荧光成像技术（如 FRET）的理想染料。在这项研究中，我们在两个吡咯香豆素骨架的基本结构上设计并合成了许多新的荧光分子，其中 Fischer 的吲哚合成和 Suzuki 偶联成功地作为有效的分子编辑方案。对这些化合物的荧光特性和进一步结构优化的检查提供了三种具有显着大斯托克斯位移和令人满意的荧光特性的新型吡咯并香豆素染料。其中，30 表现出较大的斯托克斯位移（113 nm）和强烈的荧光（φ = 0.55，λem = 523 nm），因此在生物成像研究中显示出巨大的潜力。(© Wiley-VCH Verlag GmbH & Co.