4-(4-methoxyphenyl)-dipropylamine | 107411-43-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(4-methoxyphenyl)-dipropylamine
• 英文别名: N,N-Dipropyl-p-anisidin；N,N-Di-n-propyl-p-anisidin；N,N-Dipropyl-anisidin；4-methoxy-N,N-dipropylaniline
• CAS: 107411-43-8
• 化学式: C₁₃H₂₁NO
• 分子量: 207.316
• InChiKey: FDKFYTMWAQYXLM-UHFFFAOYSA-N

物化性质

• 沸点：
  308.4±25.0 °C(Predicted)
• 密度：
  0.953±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  para-methoxyphenyldiazonium chloride 、 二正丙胺 在 盐酸 、 碳酸氢钠 作用下， 以 四氢呋喃 、 水 、 乙醚 为溶剂， 反应 14.0h， 以76%的产率得到4-(4-methoxyphenyl)-dipropylamine
  参考文献：
  名称：

  Synthesis of a Sensitive and Selective Potassium-Sensing Fluoroionophore

  摘要：

  An efficient synthesis Is reported that delivers in 5 steps and 52% overall yield a new structurally simplified fluorescent K+ sensor with Improved K+ sensitivity and selectivity over existing K+ sensors. The synthesis procedure utilizes a new template-directed oxidative C-N bond-forming macrocyclization reaction and reports new approaches to Pd(0), Sandmeyer-like and metal-free aminoarylations, as well as organotitanlum additions to vinylogous sulfonates.

  DOI：

  10.1021/ol902836c

文献信息

• Reductive Monoalkylation of Aromatic and Aliphatic Nitro Compounds and the Corresponding Amines with Nitriles
  作者：Ruel Nacario、Shailaja Kotakonda、David M. D. Fouchard、L. M. Viranga Tillekeratne、Richard A. Hudson

  DOI：10.1021/ol047580f

  日期：2005.2.1

  [reaction: see text] A simple, selective, rapid, and efficient procedure for the synthesis of secondary amines from the reductive alkylation of either aliphatic or aromatic nitro compounds and the corresponding amines is reported. Ammonium formate is used as the hydrogen source and Pd/C as the hydrogen transfer catalyst. The reaction is carried out at room temperature. The rate differences for the preferential

  [反应：见正文]报告了一种简单，选择性，快速和有效的方法，该方法由脂肪族或芳香族硝基化合物与相应的胺的还原烷基化反应合成仲胺。甲酸铵用作氢源，Pd / C用作氢转移催化剂。反应在室温下进行。相对于第三产品优先形成第二产品的速率差异是由于空间和电子因素造成的。
• Phosphorinanes as Ligands for Palladium-Catalyzed Cross-Coupling Chemistry
  作者：Tim Brenstrum、Julie Clattenburg、James Britten、Serguei Zavorine、Jeff Dyck、Alan J. Robertson、James McNulty、Alfredo Capretta

  DOI：10.1021/ol052579h

  日期：2006.1.1

  organopalladium cross-coupling chemistry. Prepared via a direct double Michael addition of a monoalkyl- or arylphosphine to phorone followed by a Wolf-Kishner reduction, phosphorinanes are relatively inexpensive to manufacture and allow modification of one of the alkyl moieties permitting steric and electronic fine-tuning of the ligands. Library screening and applications of these ligands in the Suzuki, Sonogashira

  [结构：见正文]磷化氢是一类适用于有机钯交叉偶联化学反应的膦配体。通过将单烷基膦基或芳基膦直接双迈克尔加成到佛酮中，然后进行Wolf-Kishner还原，制备了二膦酸酯，其制造相对便宜，并且允许对烷基部分之一进行修饰，从而可以对配体进行空间和电子微调。介绍了这些配体在Suzuki，Sonogashira，酮芳基化和芳基胺化反应中的文库筛选和应用。
• Substituted Oxazole Compounds with Analgesic Activity
  申请人：Merla Beatrix

  公开号：US20090069330A1

  公开（公告）日：2009-03-12

  Substituted oxazole derivatives corresponding to formula 1: a method for producing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds to treat pain, depression, urinary incontinence, diarrhoea, pruritus, alcohol and drug misuse, drug dependency, lethargy and/or anxiety.

  对应于公式1的氧唑衍生物替代物：生产这类化合物的方法，含有这类化合物的药物组合物，以及使用这类化合物治疗疼痛、抑郁、尿失禁、腹泻、瘙痒、酒精和药物滥用、药物依赖、倦怠和/或焦虑的用途。
• [EN] NOVEL SULFONYLAMINOBENZAMIDE COMPOUNDS AS ANTHELMINTICS<br/>[FR] NOUVEAUX COMPOSÉS SULFONYLAMINOBENZAMIDE UTILISÉS COMME ANTHELMINTIQUES
  申请人：NOVARTIS TIERGESUNDHEIT AG

  公开号：WO2016033341A1

  公开（公告）日：2016-03-03

  The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.

  本发明涉及一种新的化合物，其化学式为（I），其中变量的含义如索赔中所示；或其对映体或盐。化合物的化学式（I）在控制寄生虫方面具有用途，特别是在脊椎动物体内和体外的内寄生虫。
• ADHESIVE COMPOSITIONS FOR BACK-COATING DENTAL PLATE AND HARDENING COMPOSITIONS FOR DENTAL USE
  申请人：TOKUYAMA CORPORATION

  公开号：EP1348416A1

  公开（公告）日：2003-10-01

  An adhesive composition for a denture base relining material which comprises an organic solvent containing no halogen atoms such as ethyl acetate, ethyl formate or acetone, a polymer such as a copolymer of methyl methacrylate and ethyl methacrylate, and a radical polymerizable monomer such as tetramethylolmethane tetramethacrylate; and a curable composition which comprises a radical polymerizable monomer, an organic peroxide such as benzoyl peroxide, a tertiary amine compound such as diethyl-p-toluidine or dipropyl-p-toluidine, and a hydroxycarboxylic acid such as malic acid or citric acid. The adhesive composition for a denture base relining material does not contain a halogen-atom-containing organic solvent whose harmful effect has been pointed out. Further, the composition has satisfactory adhesive properties and good operability and causes no degradation in the appearance of a denture base even if it sticks to an area on the surface of the denture base other than a contact area. The dental curable composition is widely used as dental materials having little surface unpolymerized layer and good curability, e.g., dental cement, a composite resin, a resin for crown and a denture base relining material.

  一种用于义齿基托衬垫材料的粘合剂组合物，它包括不含卤素原子的有机溶剂，如乙酸乙酯、甲酸乙酯或丙酮；聚合物，如甲基丙烯酸甲酯和甲基丙烯酸乙酯的共聚物；以及可自由基聚合的单体，如四甲基丙烯酸甲酯；和一种固化组合物，它包括一种可自由基聚合的单体、一种有机过氧化物（如过氧化苯甲酰）、一种叔胺化合物（如二乙基对甲苯胺或二丙基对甲苯胺）和一种羟基羧酸（如苹果酸或柠檬酸）。 用于义齿基托衬垫材料的粘合剂组合物不含已指出其有害影响的含卤原子有机溶剂。此外，该组合物具有令人满意的粘接性能和良好的可操作性，即使粘在义齿基托表面接触区以外的区域，也不会造成义齿基托外观的下降。这种牙科固化组合物被广泛用作表面未聚合层少且固化性好的牙科材料，例如牙科粘合剂、复合树脂、牙冠用树脂和义齿基托衬垫材料。