methyl 6-((tert-butoxycarbonyl)amino)hexanoate | 128372-97-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 6-((tert-butoxycarbonyl)amino)hexanoate
• 英文别名: N-tert-butoxycarbonyl-6-aminohexanoic acid methyl ester；methyl 6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate
• CAS: 128372-97-4
• 化学式: C₁₂H₂₃NO₄
• 分子量: 245.319
• InChiKey: GJAKZXZWJMIYTC-UHFFFAOYSA-N

物化性质

• 沸点：
  330.3±25.0 °C(Predicted)
• 密度：
  1.011±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 储存条件：
  2-8℃

反应信息

• 作为反应物：
  描述：

  methyl 6-((tert-butoxycarbonyl)amino)hexanoate 在 sodium tetrahydroborate 、 lithium chloride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 以92%的产率得到N-(6-羟基己基)氨基甲酸叔丁酯
  参考文献：
  名称：

  Dendrimeric amide- and carbamate-linked lysine-based efficient molecular transporters

  摘要：

  羧酸酯和酰胺连接的赖氨酸基第二代树状寡聚物，在隔夜孵育后形成复合物后，能够非常高效地将pDNA输送到细胞内。

  DOI：

  10.1039/c7ob02552a
• 作为产物：
  描述：

  碳酸二叔丁酯 在 sodium hydroxide 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 叔丁醇 为溶剂， 生成 methyl 6-((tert-butoxycarbonyl)amino)hexanoate
  参考文献：
  名称：

  Asymmetric catalysis of intramolecular N–H insertion reactions of α-diazocarbonyls

  摘要：

  Intramolecular N-H insertion reactions of alpha-diazocarbonyl substrates are catalysed by rhodium(II) carboxylates with catalyst-dependent competition with C-H insertion and beta-elimination; asymmetric N-H insertion leading to a pipecolic acid derivative with ee up to 45% is achieved using chiral catalysts.

  DOI：

  10.1039/cc9960001465

文献信息

• Straightforward synthesis of functionalized (E)-3-acylacrylic acids
  作者：Ivan Sivák、Jakub Václav、Dušan Berkeš、Andrej Kolarovič

  DOI：10.1016/j.tet.2015.10.003

  日期：2015.11

  An experimentally simple, mild and straightforward synthetic route towards diversely functionalized (E)-3-acylacrylic acids is described, with Horner–Wadsworth–Emmons (HWE) reaction as the key step. The substrate scope and limitations of the HWE reaction were investigated with a range of β-ketophosphonates. Glyoxylic acid monohydrate was demonstrated to be fully compatible with the HWE reaction conditions

  朝不同地官能化（通过实验简单，轻度和直接合成路线ë）-3- acylacrylic酸进行了说明，与霍纳-沃兹沃思-埃蒙斯（HWE）作为关键步骤反应。基板范围和HWE反应的局限性与一系列β-ketophosphonates的进行了研究。已证明乙醛酸一水合物与HWE反应条件完全相容，因此避免了最后一步中相应的3-丙烯酸丙烯酸酯的麻烦水解，并提供了有价值的合成捷径。
• Two-way homologation of aliphatic aldehydes: Both one-carbon shortening and lengthening via the same intermediate
  作者：Jae Won Yoo、Youngran Seo、Jong Beom Park、Young Gyu Kim

  DOI：10.1016/j.tet.2019.130883

  日期：2020.2

  Aliphatic aldehydes can be homologated to both one-carbon shorter and one-carbon longer homologous carbonyl compounds through the 2–4 steps of reactions via the same intermediates, β,γ-unsaturated α-nitrosulfones, prepared from the proline-catalyzed sequential reactions of several aliphatic aldehydes with phenylsulfonylnitromethane. While the oxidative cleavage of the key intermediates gave one-carbon

  脂肪醛可通过相同的中间体β，γ-不饱和α-硝基砜，经脯氨酸催化的连续反应制备的相同中间体，通过2–4个反应，与一碳短和一碳长的同源羰基化合物同源。几种脂肪醛与苯磺酰基硝基甲烷。当关键中间体的氧化裂解得到一碳较少的同源羰基化合物时，相同关键中间体的还原随后被氧化产生了更多一碳的同源羰基化合物。
• BIO-INSPIRED AND ANTIMICROBIAL POLYMERS CONTAINING AMINO ACID-LIKE MONOMER BUILDING BLOCKS
  申请人：Joy Abraham

  公开号：US20170172147A1

  公开（公告）日：2017-06-22

  Methods for killing a microbial are provided that include introducing a functionalized amide polymer to a microbe, where the functionalized amide polymer includes a polymer backbone selected from polyesters and polyurethanes; an amide group with a pendant functional group, where the nitrogen atom of the amide group is part of the polymer backbone; and a net positive charge.

  提供了一种杀灭微生物的方法，包括向微生物引入一个功能化酰胺聚合物，其中该功能化酰胺聚合物包括从聚酯和聚氨酯中选择的聚合物骨架；一个带有挂链功能基团的酰胺基团，其中酰胺基团的氮原子是聚合物骨架的一部分；以及净正电荷。
• Radiolabeled annexin conjugates with hexose and a chelator
  申请人：NeoRx Corporation

  公开号：US05968477A1

  公开（公告）日：1999-10-19

  Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.

  放射性标记的凋亡素和修饰的凋亡素共轭物可用于成像血管血栓。还提供了制备和使用这种放射性标记的凋亡素共轭物的方法。
• Hepatic-directed compounds and reagents for preparation thereof
  申请人：NeoRx Corporation

  公开号：US05886143A1

  公开（公告）日：1999-03-23

  Hepatic-directed compounds, reagents useful in making such compounds and associated methods and compositions are discussed. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from the metabolic mechanisms encountered by compounds which are not so directed. Reagents useful in the preparation of hepatic-directed compounds include a hexose cluster characterized by multiple hexose residues connected in an iteratively branched configuration. In one embodiment, the hexose cluster comprises at least four hexose residues with each branch of the configuration having two prongs. In another embodiment, the hexose cluster comprises at least nine hexose residues with each branch of the configuration having three prongs.

  肝向化合物、制备此类化合物的有用试剂以及相关方法和组合物进行了讨论。肝向化合物通过代谢机制进行处理，这些代谢机制通常在程度或种类上与非肝向化合物所遇到的代谢机制不同。用于制备肝向化合物的有用试剂包括具有多个连接成迭代分支配置的己糖残基的己糖簇。在一个实施例中，己糖簇包括至少四个己糖残基，每个配置的分支具有两个叉。在另一个实施例中，己糖簇包括至少九个己糖残基，每个配置的分支具有三个叉。