(6-hydroxymethyl-4-oxo-4H-pyran-3-yloxy)-acetic acid | 90345-71-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: (6-hydroxymethyl-4-oxo-4H-pyran-3-yloxy)-acetic acid
• 英文别名: (6-Hydroxymethyl-4-oxo-4H-pyran-3-yloxy)-essigsaeure；2-[6-(Hydroxymethyl)-4-oxopyran-3-yl]oxyacetic acid；2-[6-(hydroxymethyl)-4-oxopyran-3-yl]oxyacetic acid
• CAS: 90345-71-4
• 化学式: C₈H₈O₆
• 分子量: 200.148
• InChiKey: ZTQKOAINFXCQOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (6-hydroxymethyl-4-oxo-4H-pyran-3-yloxy)-acetic acid 、 乙酸酐 在 吡啶 作用下， 生成 (6-acetoxymethyl-4-oxo-4H-pyran-3-yloxy)-acetic acid
  参考文献：
  名称：

  Behavior of Kojic Acid toward Acrylonitrile, Halo Acids and Hydrogen Cyanide

  摘要：

  DOI：

  10.1021/ja01543a041
• 作为产物：
  描述：

  曲酸 、 溴乙酸 在 甲醇 、 sodium methylate 作用下， 生成 (6-hydroxymethyl-4-oxo-4H-pyran-3-yloxy)-acetic acid
  参考文献：
  名称：

  Behavior of Kojic Acid toward Acrylonitrile, Halo Acids and Hydrogen Cyanide

  摘要：

  DOI：

  10.1021/ja01543a041

文献信息

• Pyrazolopyrimidine compound and a process for preparing the same
  申请人：Takamuro Iwao

  公开号：US20060135525A1

  公开（公告）日：2006-06-22

  The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R′ is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic heteromonocyclic group, (C) a substituted cyclo-lower alkyl group, (D) an optionally substituted amino group, or (E) a substituted heteroaryl group, R 2 is (a) an optionally substituted heteroaryl group or (b) an optionally substituted aryl group, Y is a single bond, a lower alkylene group or a lower alkenylene group, Z is a group of the formula: —CO—, —CH2-, S02- or a group of the formula [II]: Q is a lower alkylene group, and q is an integer of 0 or 1 or a pharmaceutically acceptable sait thereof, which has a small conductance potassium channel (SK channel) blocking activity and is useful as a medicament and a process for preparing the same.

  本发明提供了一种新型的吡唑嘧啶化合物，其化学式为[I]：其中R′为（A）取代芳基，（B）可选取代的含氮脂肪杂环基，（C）取代的环低烷基，（D）可选取代的氨基或（E）取代的杂环芳基；R2为（a）可选取代的杂环芳基或（b）可选取代的芳基；Y为单键，低碳基烷基或低碳基烯基；Z为式[II]的基团：其中Q为低碳基烷基，q为0或1的整数，或其药学上可接受的盐。该化合物具有小电导钾通道（SK通道）阻滞活性，并可作为药物使用，以及其制备方法。
• PYRAZOLOPYRIMIDINE COMPOUND AND PROCESS FOR PREPARING THE SAME
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1585481A2

  公开（公告）日：2005-10-19
• US7384952B2
  申请人：——

  公开号：US7384952B2

  公开（公告）日：2008-06-10
• [EN] A PYRAZOLOPYRIMIDINE COMPOUND AND A PROCESS FOR PREPARING THE SAME<br/>[FR] COMPOSE DE PYRAZOLOPYRIMIDINE ET PROCEDE DE PREPARATION ASSOCIE
  申请人：TANABE SEIYAKU CO

  公开号：WO2004064721A2

  公开（公告）日：2004-08-05

  The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R' is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic heteromonocyclic group, (C) a substituted cyclo-lower alkyl group, (D) an optionally substituted amino group, or (E) a substituted heteroaryl group, R2 is (a) an optionally substituted heteroaryl group or (b) an optionally substituted aryl group, Y is a single bond, a lower alkylene group or a lower alkenylene group, Z is a group of the formula: -CO-, -CH2-, -S02- or a group of the formula[II]: Q is a lower alkylene group, and q is an integer of 0 or 1 or a pharmaceutically acceptable sait thereof, which has a small conductance potassium channel (SK channel) blocking activity and is useful as a medicament and a process for preparing the same.
• Behavior of Kojic Acid toward Acrylonitrile, Halo Acids and Hydrogen Cyanide
  作者：Charles D. Hurd、Swiatoslaw Trofimenko

  DOI：10.1021/ja01543a041

  日期：1958.5