N₄-(9-ethyl-9H-carbazol-3-yl)-4-amino-4-oxo-butanoic acid | 477308-70-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N₄-(9-ethyl-9H-carbazol-3-yl)-4-amino-4-oxo-butanoic acid
• 英文别名: N-(9-ethyl-9H-carbazol-3-yl)-succinamic acid；4-[(9-ethyl-9H-carbazol-3-yl)amino]-4-oxobutanoic acid；4-[(9-ethylcarbazol-3-yl)amino]-4-oxobutanoic acid
• CAS: 477308-70-6
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.353
• InChiKey: BKPRNNXPZVIGMI-UHFFFAOYSA-N

物化性质

• 沸点：
  561.7±46.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  71.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氨基-9-乙基咔唑 、 丁二酸 在 N-甲基吗啉 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以78%的产率得到N₄-(9-ethyl-9H-carbazol-3-yl)-4-amino-4-oxo-butanoic acid
  参考文献：
  名称：

  Photoinduced Electron Transfer between Non-Native Donor−Acceptor Moieties Incorporated in Synthetic Polypeptide Aggregates

  摘要：

  [GRAPHICS]A series of analogous photoactive polypeptides that form helical homo and hetero aggregates in aqueous media were prepared. A pyrenyl ketone (the principal chromophore and an electron acceptor) was attached to the N-termini. An electron donor, amidoethylcarbazole, was introduced as a side chain of a non-native amino acid, NCb, 14 residues away. Photoinduced electron-transfer rate constants of the order of 10(8) s(-1) between remote pyrene and carbazole were measured.

  DOI：

  10.1021/ol026656+

文献信息

• [EN] HEPATITIS C VIRUS ENTRY INHIBITORS<br/>[FR] INHIBITEURS DE LA PÉNÉTRATION DU VIRUS DE L'HÉPATITE C
  申请人：IMMUSOL INC

  公开号：WO2008021745A2

  公开（公告）日：2008-02-21

  [EN] The present invention relates to the use of tricyclic diphenylamine derivative compounds for prevention and/or treatment of Hepatitis C virus (HCV) infection by inhibiting HCV entry into permissive cells.
  [FR] La présente invention concerne l'utilisation de composés dérivés de la diphénylamine tricyclique pour la prévention et/ou le traitement d'une infection par le virus de l'hépatite C (Hepatitis C Virus : HCV) en inhibant la pénétration du HCV dans les cellules permissives.
• Photoinduced Electron Transfer between Non-Native Donor−Acceptor Moieties Incorporated in Synthetic Polypeptide Aggregates
  作者：Guilford Jones、Valentine I. Vullev

  DOI：10.1021/ol026656+

  日期：2002.11.1

  [GRAPHICS]A series of analogous photoactive polypeptides that form helical homo and hetero aggregates in aqueous media were prepared. A pyrenyl ketone (the principal chromophore and an electron acceptor) was attached to the N-termini. An electron donor, amidoethylcarbazole, was introduced as a side chain of a non-native amino acid, NCb, 14 residues away. Photoinduced electron-transfer rate constants of the order of 10(8) s(-1) between remote pyrene and carbazole were measured.