Catalyst- and Additive-Free Chemoselective Transfer Hydrogenation of α-Keto Amides to α-Hydroxy Amides by Sodium Formate
作者:Feiyue Hao、Zhenyu Gu、Guyue Liu、Wubing Yao、Huajiang Jiang、Jiashou Wu
DOI:10.1002/ejoc.201901073
日期:2019.9.15
A catalyst‐ and additive‐free chemoselective transfer hydrogenation of α‐keto amides to α‐hydroxy amides is easily achieved by using sodium formate as a hydrogen source. Control experiments suggest that the NH group of α‐keto amides is crucial for the chemoselective reduction through the formation of hydrogen bonds.
通过使用甲酸钠作为氢源,可以轻松实现无催化剂和无添加剂的α-酮酰胺的化学选择性转移氢化为α-羟基酰胺。对照实验表明,α-酮酰胺的NH基对于通过形成氢键进行化学选择性还原至关重要。