Boc-D-Adec-OH | 67862-09-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-D-Adec-OH
• 英文别名: (R)-2-((tert-butoxycarbonyl)amino)decanoic acid；(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]decanoic acid
• CAS: 67862-09-3
• 化学式: C₁₅H₂₉NO₄
• 分子量: 287.4
• InChiKey: OXOZMSCSDJPGHN-GFCCVEGCSA-N

物化性质

• 沸点：
  416.6±28.0 °C(Predicted)
• 密度：
  1.013±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Boc-D-Adec-OH 在 盐酸 作用下， 反应 1.0h， 生成
  参考文献：
  名称：

  Synthesis of chiral α-amino acids

  摘要：

  A novel method for the synthesis of chiral alpha-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the alpha-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)02433-4
• 作为产物：
  描述：

  tert-butyl N-[(2R)-1-phenylmethoxydecan-2-yl]carbamate 在 palladium dihydroxide ruthenium trichloride 、 sodium periodate 、 氢气 作用下， 以 甲醇 、 四氯化碳 、 水 、 乙腈 为溶剂， 反应 5.0h， 生成 Boc-D-Adec-OH
  参考文献：
  名称：

  Synthesis of chiral α-amino acids

  摘要：

  A novel method for the synthesis of chiral alpha-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the alpha-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)02433-4

文献信息

• POLYMYXIN-BASED COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS
  申请人：Universitat de Barcelona

  公开号：EP3636659A1

  公开（公告）日：2020-04-15

  It relates to polymyxin analogues having a disulfide bond and an amino alcohol group adjacent to the disulfide bond, and optionally, an ester bond in the peptide backbone, which are useful as antibacterial agent, as well as to pharmaceutical compositions comprising them. It also relates to a key intermediate compound of formula (II) and its preparation process.

  这涉及到具有二硫键和邻近二硫键的氨基醇基团的聚霉素类似物，以及可选地，在肽骨架中具有酯键，这些类似物可用作抗菌剂，以及包含它们的制药组合物。还涉及到公式（II）的关键中间化合物及其制备过程。
• Mori, Tomonori; Miyagi, Marie; Suzuki, Kengo, Heterocycles, 2007, vol. 72, p. 275 - 291
  作者：Mori, Tomonori、Miyagi, Marie、Suzuki, Kengo、Shibasaki, Mitsuhito、Saikawa, Yoko、Nakata, Masaya

  DOI：——

  日期：——