1-(6-Hydroxy-3'-methoxy-biphenyl-3-yl)-pentan-1-one | 565203-88-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(6-Hydroxy-3'-methoxy-biphenyl-3-yl)-pentan-1-one
• 英文别名: 1-(6-Hydroxy-3'-methoxy[1,1'-biphenyl]-3-yl)-1-pentanone；1-[4-hydroxy-3-(3-methoxyphenyl)phenyl]pentan-1-one
• CAS: 565203-88-5
• 化学式: C₁₈H₂₀O₃
• 分子量: 284.355
• InChiKey: CSLSCTKLTOYGND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(6-Hydroxy-3'-methoxy-biphenyl-3-yl)-pentan-1-one 在 bis-triphenylphosphine-palladium(II) chloride 、 二乙基异丙基胺 作用下， 生成 1-(3'-Methoxy-6-trimethylsilanylethynyl-biphenyl-3-yl)-pentan-1-one
  参考文献：
  名称：

  Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor

  摘要：

  Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The synthesis and detailed biological data of this series of analogues are presented. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00122-7
• 作为产物：
  描述：

  1-(6,3'-Dimethoxy-biphenyl-3-yl)-pentan-1-one 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 1-(6-Hydroxy-3'-methoxy-biphenyl-3-yl)-pentan-1-one
  参考文献：
  名称：

  Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor

  摘要：

  Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The synthesis and detailed biological data of this series of analogues are presented. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00122-7

文献信息

• Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor
  作者：Nan-Horng Lin、Le Wang、Jerry Cohen、Wen-Zhen Gu、David Frost、Haiying Zhang、Saul Rosenberg、Hing Sham

  DOI：10.1016/s0960-894x(03)00122-7

  日期：2003.4

  Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The synthesis and detailed biological data of this series of analogues are presented. (C) 2003 Elsevier Science Ltd. All rights reserved.