(E)-4-(6,8-dihydroxynaphthalen-2-yl)but-3-en-2-one | 1370531-90-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-4-(6,8-dihydroxynaphthalen-2-yl)but-3-en-2-one
• 英文别名: resveratrone
• CAS: 1370531-90-0
• 化学式: C₁₄H₁₂O₃
• 分子量: 228.247
• InChiKey: MQTDJIOARCRXRY-NSCUHMNNSA-N

物化性质

• 沸点：
  487.8±14.0 °C(Predicted)
• 密度：
  1.304±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  trans-resveratrone 以 甲醇 为溶剂， 反应 0.03h， 生成 (E)-4-(6,8-dihydroxynaphthalen-2-yl)but-3-en-2-one
  参考文献：
  名称：

  WATER-SOLUBLE FLUORESCENCE COMPOUND AND METHOD FOR PREPARING THE SAME

  摘要：

  本发明提供了一种水溶性荧光化合物白藜芦醇 6-O-β-葡萄糖苷[(E)-4-(8-羟基-6-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)萘-2-基)丁-3-烯-2-酮]及其具有至少一个水溶性取代基的化合物的衍生物，以及通过白藜芦醇 3-O-β-葡萄糖苷及其具有不发光的化合物的衍生物进行光化学反应制备上述化合物的方法。所述新的水溶性荧光化合物具有单光子吸收特性和/或双光子吸收特性，以及几乎没有毒性，可在需要水溶性荧光特性的领域（诊断、荧光探针、体内成像、显示等）中得到有益利用。

  公开号：

  US20150031867A1

文献信息

• Photochemical generation of a new, highly fluorescent compound from non-fluorescent resveratrol
  作者：Ilseung Yang、Eunha Kim、Junhee Kang、Hyouksoo Han、Soohwan Sul、Seung Bum Park、Seong Keun Kim

  DOI：10.1039/c2cc30940h

  日期：——

  UV irradiation of trans-resveratrol leads to its photochemical transformation to a new, highly fluorescent compound, whose chemical structure was unambiguously identified. The new compound has large values of fluorescence quantum yield, Stokes' shift, and two-photon absorption cross section, which make it suitable for bio-imaging, multi-color labeling, and two-photon microscopy.

  紫外线照射反式白藜芦醇可使其光化学转化为一种新的高荧光化合物，其化学结构已被明确确定。这种新化合物具有较大的荧光量子产率、斯托克斯位移和双光子吸收截面值，因此适用于生物成像、多色标记和双光子显微镜。
• Water-soluble fluorescence compound and method for preparing the same
  申请人：SNU R&DB FOUNDATION

  公开号：US10077399B2

  公开（公告）日：2018-09-18

  The present invention provides a water-soluble fluorescent compound of resveratrone 6-O-β-glucoside [(E)-4-(8-hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)naphthalen-2-yl)but-3-en-2-one] and its derivatives of Formula I which have at least one water-soluble substituent, and a method for preparing the same by a photochemical reaction of resveratrol 3-O-β-glucoside and its derivatives of having Formula 3 which are not fluorescent. Said new water-soluble fluorescent compounds has single-photon absorptive characteristics and/or two-photon absorptive characteristics as well as no or little toxicity, and can be usefully utilized in fields that requires water-soluble fluorescent characteristics (diagnosis, fluorescent probe, in vivo imaging, display, etc.).

  本发明提供了一种白藜芦醇 6-O-β-葡萄糖苷[(E)-4-(8-羟基-6-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)萘-2-基)丁-3-烯-2-酮]的水溶性荧光化合物及其具有至少一个水溶性取代基的式 I 衍生物、以及一种通过白藜芦醇 3-O-β-葡萄糖苷及其式 3 衍生物的光化学反应制备上述物质的方法。 上述新型水溶性荧光化合物具有单光子吸收特性和/或双光子吸收特性，且无毒或毒性很小，可用于需要水溶性荧光特性的领域（诊断、荧光探针、体内成像、显示等）。
• High efficiency fluorescent compound and method for preparing the same
  申请人：Kim Seong Keun

  公开号：US10787607B2

  公开（公告）日：2020-09-29

  The present invention provides a fluorescent resveratrone [(E)-4-(6,8-dihydroxynaphthalen-2-yl)but-3-en-2-one] and its derivatives having Formula 1 and a method for preparing the same by a photochemical reaction of resveratrol and its derivatives which are not fluorescent having Formula 7 or Formula 8. The new fluorescent compounds of the present invention has single-photon absorptive characteristics and/or two-photon absorptive characteristics as well as no or little toxicity according to a cytotoxicity test and can be usefully utilized in the field of organic fluorescent element, display element, spectrometer, two-photon absorptive storing device, laser micro processing apparatus, photo dynamic therapy apparatus and the like.

  本发明提供了一种具有荧光性的白藜芦醇酮[(E)-4-(6,8-二羟基萘-2-基)丁-3-烯-2-酮]及其具有式 1 的衍生物，以及一种通过白藜芦醇及其具有式 7 或式 8 的不具有荧光性的衍生物的光化学反应制备白藜芦醇酮及其衍生物的方法。本发明的新型荧光化合物具有单光子吸收特性和/或双光子吸收特性，并且根据细胞毒性测试没有毒性或毒性很小，可以在有机荧光元件、显示元件、光谱仪、双光子吸收存储设备、激光微处理设备、光动力治疗设备等领域得到有效利用。
• HIGH EFFICIENCY FLUORESCENT COMPOUND AND METHOD FOR PREPARING THE SAME
  申请人：Kim Seong Keun

  公开号：US20190330524A1

  公开（公告）日：2019-10-31

  The present invention provides a fluorescent resveratrone [(E)-4-(6,8-dihydroxynaphthalen-2-yl)but-3-en-2-one] and its derivatives having Formula 1 and a method for preparing the same by a photochemical reaction of resveratrol and its derivatives which are not fluorescent having Formula 7 or Formula 8. The new fluorescent compounds of the present invention has single-photon absorptive characteristics and/or two-photon absorptive characteristics as well as no or little toxicity according to a cytotoxicity test and can be usefully utilized in the field of organic fluorescent element, display element, spectrometer, two-photon absorptive storing device, laser micro processing apparatus, photo dynamic therapy apparatus and the like.
• ANTICANCER FLUORESCENT SUBSTANCE DERIVED FROM NATURAL MATERIALS
  申请人：SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

  公开号：US20210177992A1

  公开（公告）日：2021-06-17

  Provided is a composition for preventing or treating cancer, the composition including resveratrone, resveratrone glucoside, or a combination thereof as an active ingredient.