Di-n-butoxydisulfan | 3359-06-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Di-n-butoxydisulfan
• 英文别名: dibutoxydisulfane；thiosulfurous acid O,O'-dibutyl ester；Thioschwefligsaeure-O,O'-dibutylester；Dibutyloxydisulfid；Butylthiosulfit；Dibutyloxy-disulfid；1,2-Dibutoxydisulfane；1-(butoxydisulfanyl)oxybutane
• CAS: 3359-06-6
• 化学式: C₈H₁₈O₂S₂
• 分子量: 210.362
• InChiKey: DMOOXBVIMYQNBE-UHFFFAOYSA-N

物化性质

• 沸点：
  252.1±23.0 °C(Predicted)
• 密度：
  1.045±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  sodium butanolate 在 二氯化二硫 作用下， 生成 Di-n-butoxydisulfan
  参考文献：
  名称：

  Stamm; Wintzer, Chemische Berichte, 1937, vol. 70, p. 2058

  摘要：

  DOI：

文献信息

• Antibacterial S-heterosubstituted disulfides
  申请人：Turos Edward

  公开号：US10350177B2

  公开（公告）日：2019-07-16

  Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

  合成衍生的 S,S-互二取代二硫化物对多种细菌（包括金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和土拉弗氏菌）具有强效的体外抗菌活性。本发明提供了有效治疗微生物/细菌感染的化合物、方法和组合物，特别是治疗对传统抗生素产生抗药性的细菌引起的感染。
• Blaschette, Armand; Naeveke, Martina; Jones, Peter G., Zeitschrift fur Naturforschung, B: Chemical Sciences, 1991, vol. 46, # 1, p. 5 - 14
  作者：Blaschette, Armand、Naeveke, Martina、Jones, Peter G.

  DOI：——

  日期：——
• Organic Esters of Bivalent Sulfur. I. Dialkoxy Disulfides
  作者：Q. E. Thompson、M. M. Crutchfield、M. W. Dietrich、E. Pierron

  DOI：10.1021/jo01019a044

  日期：1965.8
• Synthesis and antimicrobial activities of structurally novel S,S′-bis(heterosubstituted) disulfides
  作者：Praveen Ramaraju、Danielle Gergeres、Edward Turos、Sonja Dickey、Daniel V. Lim、John Thomas、Burt Anderson

  DOI：10.1016/j.bmcl.2012.04.056

  日期：2012.6

  The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S'-bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillinresistant S. aureus and F. tularensis. (C) 2012 Elsevier Ltd. All rights reserved.
• ANTIBACTERIAL S-HETEROSUBSTITUTED DISULFIDES
  申请人：Turos Edward

  公开号：US20100204337A1

  公开（公告）日：2010-08-12

  Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus , methicillin-resistant Staphylococcus aureus and Francisella tularensis . The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.