gamma cyclodextrin

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: gamma cyclodextrin
• 英文别名: Cyclooctaamylose；(1S,5R,6S,10R,11S,15R,16S,20R,21S,25R,26S,30R,31S,35R,36S,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R,50R,51R,52R,53R,54R,55R,56R)-5,10,15,20,25,30,35,40-octakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo[36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36]hexapentacontane-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecol
• 化学式: C₄₈H₈₀O₄₀
• 分子量: 1297.14
• InChiKey: GDSRMADSINPKSL-KFWIRYAQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -17.2
• 重原子数：
  88
• 可旋转键数：
  8
• 环数：
  30.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  633
• 氢给体数：
  24
• 氢受体数：
  40

反应信息

• 作为反应物：
  描述：

  利伐沙班 、 gamma cyclodextrin 在 甲醇 作用下， 以 2,2,2-三氟乙醇 为溶剂， 反应 0.25h， 生成 rivaroxaban-gamma cyclodextrin
  参考文献：
  名称：

  [EN] NEW CO CRYSTALS USEFUL IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS
  [FR] NOUVEAUX CO-CRISTAUX UTILES DANS LA PRÉPARATION DE COMPOSITIONS PHARMACEUTIQUES

  摘要：

  该发明涉及与草酸和γ-环糊精形成的INN利伐沙班的新共晶体，其是5-氯-N-///5S/-2-氧代-3-/4-/3-氧代-吗啉-4-基-苯基-1,3-噁唑啉-5-基-甲基-噻吩-2-羧酰胺的新共晶体。该发明还涉及制备利伐沙班和草酸的共晶体的方法。根据该方法，非晶态或结晶利伐沙班或利伐沙班的水合物、溶剂合物或共晶体溶解在有机溶剂、水或有机溶剂和水的混合物中，向溶液中加入草酸并去除溶剂。根据该发明，还提供了制备利伐沙班和γ-环糊精的共晶体的方法。根据该方法，非晶态或结晶利伐沙班或利伐沙班的水合物、溶剂合物或共晶体溶解在有机溶剂、水或有机溶剂和水的混合物中，向溶液中加入γ-环糊精并去除溶剂。

  公开号：

  WO2013054146A1

文献信息

• Injectable phenol formulations and methods of their use
  申请人：SAOL INTERNATIONAL DEVELOPMENT LTD.

  公开号：US11083694B2

  公开（公告）日：2021-08-10

  Phenol formulations including phenol and an encapsulation agent, such as a cyclodextrin or derivatives thereof, and uses of such formulations.

  包括苯酚和封装剂（如环糊精或其衍生物）的苯酚制剂及其用途。
• Injectable phenol formulations and methods of manufacture
  申请人：SAOL INTERNATIONAL DEVELOPMENT LTD.

  公开号：US11083695B2

  公开（公告）日：2021-08-10

  Phenol formulations including phenol and an encapsulation agent, such as a cyclodextrin or derivatives thereof, and uses of such formulations.

  包括苯酚和封装剂（如环糊精或其衍生物）的苯酚制剂及其用途。
• APPARATUS AND METHODS FOR BIOSYNTHETIC PRODUCTION OF CANNABINOIDS
  申请人：FULL SPECTRUM LABORATORIES LIMITED

  公开号：US20160340629A1

  公开（公告）日：2016-11-24

  The present invention provides an apparatus and methods for producing tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) and cannabichromenic acid (CBCA) in different ratios. The apparatus comprises:(i) a bioreactor comprising (a) an automated supply system configured to deliver a first automated supply of cannabigerolic acid (CBGA), a cannabinoid acid synthase, and a reaction mixture; and (b) a second automated system to cease the reaction; (ii) a controller configured to modify a property of the reaction mixture to produce the desired products; and (iii) an extractor configured to recover the tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) or cannabidiolic acid (CBDA) and cannabichromenic acid.
• TUNGSTEN-PROCESSING SLURRY WITH CATIONIC SURFACTANT AND CYCLODEXTRIN
  申请人：Cabot Microelectronics Corporation

  公开号：US20170121560A1

  公开（公告）日：2017-05-04

  Described are chemical-mechanical polishing compositions (e.g., slurries) and methods of using the slurries for chemical-mechanical polishing (or planarizing) a surface of a substrate that contains tungsten, the compositions containing cationic surfactant and cyclodextrin.
• CMP PROCESSING COMPOSITION COMPRISING ALKYLAMINE AND CYCLODEXTRIN
  申请人：Cabot Microelectronics Corporation

  公开号：US20170183540A1

  公开（公告）日：2017-06-29

  Described are compositions useful in methods for chemical-mechanical processing a surface of a substrate, especially a substrate that contains dielectric material, wherein the composition contains cyclodextrin and an alkylamine.