{4-[tert-Butoxycarbonyl-(2-oxo-tetrahydro-furan-3-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester | 860495-53-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: {4-[tert-Butoxycarbonyl-(2-oxo-tetrahydro-furan-3-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[4-[(2-methylpropan-2-yl)oxycarbonylamino]butyl]-N-[(2-oxooxolan-3-yl)methyl]carbamate
• CAS: 860495-53-0
• 化学式: C₁₉H₃₄N₂O₆
• 分子量: 386.489
• InChiKey: YUQFUYGBFKLLHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  94.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  {4-[tert-Butoxycarbonyl-(2-oxo-tetrahydro-furan-3-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester 在 劳森试剂 、 4-二甲氨基吡啶 、 sodium tetrahydroborate 、 四丁基氟化铵 、 三乙胺 、 nickel dichloride 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 63.0h， 生成 Methanesulfonic acid 4-[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-3-{[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-methyl}-butyl ester
  参考文献：
  名称：

  Synthesis of a Laterally Branched Polyamine from α-Methylene-γ-butyrolactone

  摘要：

  A polyamine derivative was prepared from alpha-methylene-gamma-butyrolactone. This method used Michael addition and lactone aminolysis followed by the nucleophilic substitution of the hydroxyl group by an azido group. The coupling of a lipophilic alkyne led to a polyamine that will be probed as a gene transfer agent.

  DOI：

  10.1021/ol050803x
• 作为产物：
  描述：

  {4-[(2-Oxo-tetrahydro-furan-3-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester 、 二碳酸二叔丁酯 以 二氯甲烷 为溶剂， 反应 20.0h， 以89%的产率得到{4-[tert-Butoxycarbonyl-(2-oxo-tetrahydro-furan-3-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis of a Laterally Branched Polyamine from α-Methylene-γ-butyrolactone

  摘要：

  A polyamine derivative was prepared from alpha-methylene-gamma-butyrolactone. This method used Michael addition and lactone aminolysis followed by the nucleophilic substitution of the hydroxyl group by an azido group. The coupling of a lipophilic alkyne led to a polyamine that will be probed as a gene transfer agent.

  DOI：

  10.1021/ol050803x

文献信息

• Synthesis of a Laterally Branched Polyamine from α-Methylene-γ-butyrolactone
  作者：Mickaël Jean、Myriam Le Roch、Jacques Renault、Philippe Uriac

  DOI：10.1021/ol050803x

  日期：2005.6.1

  A polyamine derivative was prepared from alpha-methylene-gamma-butyrolactone. This method used Michael addition and lactone aminolysis followed by the nucleophilic substitution of the hydroxyl group by an azido group. The coupling of a lipophilic alkyne led to a polyamine that will be probed as a gene transfer agent.