(S)-2-Carbazol-9-yl-succinic acid 1-benzyl ester | 883977-41-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (S)-2-Carbazol-9-yl-succinic acid 1-benzyl ester
• 英文别名: (3S)-3-carbazol-9-yl-4-oxo-4-phenylmethoxybutanoic acid
• CAS: 883977-41-1
• 化学式: C₂₃H₁₉NO₄
• 分子量: 373.408
• InChiKey: VCADJWLHZJEIKO-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-2-Carbazol-9-yl-succinic acid 1-benzyl ester 在 N-甲基吗啉 、 palladium on activated charcoal 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 、 环己烯 作用下， 以 二氯甲烷 、 异丙醇 为溶剂， 反应 4.0h， 生成 (S)-2-Carbazol-9-yl-N-[4-((S)-3-carbazol-9-yl-3-carboxy-propionylamino)-butyl]-succinamic acid
  参考文献：
  名称：

  Magnetically Responsive Carboxylated Magnetite-Polydipyrrole/Polydicarbazole Nanocomposites of Core−Shell Morphology. Preparation, Characterization, and Use in DNA Hybridization

  摘要：

  Novel bis-heterocyclic mono- and dicarboxylated dipyrrole and dicarbazole monomers have been synthesized in a modular manner. Their oxidative polymerization around magnetite nanosized particles has been investigated and optimized toward new magnetic magnetite-polydipyrrole/polydicarbazole nanocomposites (NCs) of a core-shell morphology. These NCs were thoroughly characterized by FT-IR, TGA (Thermal Gravimetric Analysis), low- and high-resolution TEM/HR-TEM microscopies, and Mossbauer spectroscopy along with magnetization studies. Exploiting the versatile COOH chemistry (activation by water-soluble diimides) introduced by the polymeric shell, DNA hybridization experiments have been conducted onto NC surfaces using an efficient blue-colored HRP-based enzymatic screening biological system. Highly parallel NC-supported DNA hybridization experimentations revealed that these NCs presented an interesting potential for DNA-based diagnostic applications.

  DOI：

  10.1021/ja050285l
• 作为产物：
  描述：

  2,5-二甲氧基四氢呋喃 、 (S)-3-amino-4-(benzyloxy)-4-oxobutanoic acid 在 盐酸 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以30%的产率得到(S)-2-Carbazol-9-yl-succinic acid 1-benzyl ester
  参考文献：
  名称：

  Magnetically Responsive Carboxylated Magnetite-Polydipyrrole/Polydicarbazole Nanocomposites of Core−Shell Morphology. Preparation, Characterization, and Use in DNA Hybridization

  摘要：

  Novel bis-heterocyclic mono- and dicarboxylated dipyrrole and dicarbazole monomers have been synthesized in a modular manner. Their oxidative polymerization around magnetite nanosized particles has been investigated and optimized toward new magnetic magnetite-polydipyrrole/polydicarbazole nanocomposites (NCs) of a core-shell morphology. These NCs were thoroughly characterized by FT-IR, TGA (Thermal Gravimetric Analysis), low- and high-resolution TEM/HR-TEM microscopies, and Mossbauer spectroscopy along with magnetization studies. Exploiting the versatile COOH chemistry (activation by water-soluble diimides) introduced by the polymeric shell, DNA hybridization experiments have been conducted onto NC surfaces using an efficient blue-colored HRP-based enzymatic screening biological system. Highly parallel NC-supported DNA hybridization experimentations revealed that these NCs presented an interesting potential for DNA-based diagnostic applications.

  DOI：

  10.1021/ja050285l

文献信息

• SURFACE-MODIFIED POLYMER FILMS
  申请人：Lellouche Jean-Paul

  公开号：US20110306722A1

  公开（公告）日：2011-12-15

  Surface-modified polymer films for coating are provided, wherein the surface is modified by covalent binding of nano- or micro-particles comprising a photoreactive species. The surface of the polymer film, e.g. a parylene film, may be modified by covalent binding of nano- or micro-particles of a polymer, e.g. a conductive bifunctional polymer further comprising a chemically reactive functional group, or of a hybrid organic-inorganic oxide, e.g., silica, network comprising a photoreactive species. Further provided are: (i) polymerizable monomers, the conductive bifunctional polymers obtained therefrom; (ii) a hybrid photoreactive organic-inorganic oxide network; and (iii) micro- or nano-particles made from (i) or (ii).

  提供用于涂层的表面改性聚合物薄膜，其中通过共价结合包含光反应物种的纳米或微米颗粒来改性表面。聚合物薄膜的表面，例如帕里林薄膜，可以通过共价结合聚合物的纳米或微米颗粒来改性，例如包含化学反应性官能团的导电双官能聚合物，或者包含光反应物种的混合有机-无机氧化物，例如二氧化硅，网络。还提供：(i)可聚合单体，由此得到的导电双官能聚合物；(ii)混合光反应有机-无机氧化物网络；和(iii)由(i)或(ii)制成的微米或纳米颗粒。
• US8486534B2
  申请人：——

  公开号：US8486534B2

  公开（公告）日：2013-07-16
• Magnetically Responsive Carboxylated Magnetite-Polydipyrrole/Polydicarbazole Nanocomposites of Core−Shell Morphology. Preparation, Characterization, and Use in DNA Hybridization
  作者：Jean-Paul Lellouche、Govindaraji Senthil、Augustine Joseph、Ludmila Buzhansky、Ian Bruce、Erika R. Bauminger、Jacob Schlesinger

  DOI：10.1021/ja050285l

  日期：2005.8.1

  Novel bis-heterocyclic mono- and dicarboxylated dipyrrole and dicarbazole monomers have been synthesized in a modular manner. Their oxidative polymerization around magnetite nanosized particles has been investigated and optimized toward new magnetic magnetite-polydipyrrole/polydicarbazole nanocomposites (NCs) of a core-shell morphology. These NCs were thoroughly characterized by FT-IR, TGA (Thermal Gravimetric Analysis), low- and high-resolution TEM/HR-TEM microscopies, and Mossbauer spectroscopy along with magnetization studies. Exploiting the versatile COOH chemistry (activation by water-soluble diimides) introduced by the polymeric shell, DNA hybridization experiments have been conducted onto NC surfaces using an efficient blue-colored HRP-based enzymatic screening biological system. Highly parallel NC-supported DNA hybridization experimentations revealed that these NCs presented an interesting potential for DNA-based diagnostic applications.