indolizine-1,2,3-triyltris((3-methoxyphenyl)methanone) | 1352441-15-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: indolizine-1,2,3-triyltris((3-methoxyphenyl)methanone)
• 英文别名: [2,3-Bis(3-methoxybenzoyl)indolizin-1-yl]-(3-methoxyphenyl)methanone；[2,3-bis(3-methoxybenzoyl)indolizin-1-yl]-(3-methoxyphenyl)methanone
• CAS: 1352441-15-6
• 化学式: C₃₂H₂₅NO₆
• 分子量: 519.554
• InChiKey: DYHFEQDFPSOOFB-UHFFFAOYSA-N

物化性质

• 熔点：
  121-122 °C
• 密度：
  1.22±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  83.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  吡啶 、 3-甲氧基苯乙酮 在 碘 、 二甲基亚砜 作用下， 反应 36.0h， 以62%的产率得到indolizine-1,2,3-triyltris((3-methoxyphenyl)methanone)
  参考文献：
  名称：

  Convergent domino synthesis of 1,2,3-triaroylindolizines from methyl ketones and pyridines via self-division of labor strategy

  摘要：

  A highly efficient method for the synthesis of 1,2,3-triaroylindolizines has been established from readily available methyl ketones and pyridines in the presence of iodine. This reaction also examplified the self-division of labor strategy in convergent domino synthesis. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.06.091

文献信息

• One-pot multicomponent synthesis of polysubstituted indolizines
  作者：Zhenjun Mao、Xuejian Li、Xufeng Lin、Ping Lu、Yanguang Wang

  DOI：10.1016/j.tet.2011.10.083

  日期：2012.1

  Concise and efficient four-component tandem approaches to polysubstituted indolizines have been developed under metal-free and mild aerobic conditions in refluxing acetonitrile. The mechanism of the novel reactions was proposed involving the formation of pyridinium ylides and alpha,beta-unsaturated ketones with subsequent 1,3-dipolar cycloaddition and aromatization reaction. (C) 2011 Elsevier Ltd. All rights reserved.