1,3-bis(3-methoxyphenyl)propane | 124778-34-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,3-bis(3-methoxyphenyl)propane
• 英文别名: 1,3-Bis-(3-methoxy-phenyl)-propan；1-Methoxy-3-[3-(3-methoxyphenyl)propyl]benzene
• CAS: 124778-34-3
• 化学式: C₁₇H₂₀O₂
• 分子量: 256.345
• InChiKey: SKKKJUGPTUYGSH-UHFFFAOYSA-N

物化性质

• 沸点：
  368.6±22.0 °C(Predicted)
• 密度：
  1.035±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3-bis(3-methoxyphenyl)propane 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 3,3'-propanediyl-di-phenol
  参考文献：
  名称：

  A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism

  摘要：

  Targeting Streptococcus mutans is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product honokiol. Herein, a structure activity relationship (SAR) study to ascertain structural motifs key to inhibition is outlined. Furthermore, mechanism studies show that bacterial membrane disruption is central to the bacterial growth inhibition. During this process, it was discovered that analog C2 demonstrated a 4-fold better therapeutic index compared to the commercially available antimicrobial cetylpyridinium chloride (CPC) making it a viable alternative for oral care.

  DOI：

  10.1021/acsinfecdis.9b00190
• 作为产物：
  描述：

  3-甲氧基苯乙酮 在 sodium tetrahydroborate 、 三氟化硼乙醚 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 6.0h， 生成 1,3-bis(3-methoxyphenyl)propane
  参考文献：
  名称：

  A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism

  摘要：

  Targeting Streptococcus mutans is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product honokiol. Herein, a structure activity relationship (SAR) study to ascertain structural motifs key to inhibition is outlined. Furthermore, mechanism studies show that bacterial membrane disruption is central to the bacterial growth inhibition. During this process, it was discovered that analog C2 demonstrated a 4-fold better therapeutic index compared to the commercially available antimicrobial cetylpyridinium chloride (CPC) making it a viable alternative for oral care.

  DOI：

  10.1021/acsinfecdis.9b00190

文献信息

• Ru-Catalyzed Completely Deoxygenative Coupling of 2-Arylethanols through Base-Induced Net Decarbonylation
  作者：Seetharaman Manojveer、Sebastian J. K. Forrest、Magnus T. Johnson

  DOI：10.1002/chem.201705208

  日期：2018.1.19

  Substituted arylethanols can be coupled by using a readily available Ru catalyst in a fully deoxygenative manner to produce hydrocarbon chains in one step. Control experiments indicate that the first deoxygenation occurs through an aldol condensation, whereas the second occurs through a base‐induced net decarbonylation. This double deoxygenation enables further development in the use of alcohols as

  可以通过使用容易获得的Ru催化剂以完全脱氧的方式偶联取代的芳基乙醇，从而一步生成烃链。对照实验表明，第一次脱氧通过羟醛缩合发生，而第二次通过碱诱导的净脱羰发生。这种双重脱氧使得在将醇用作通用和绿色烷基化试剂以及其他领域（例如脱氧和过度官能化的生物质的提质以生产烃）中的进一步开发成为可能。
• [EN] BISPHENOL COMPOUNDS<br/>[FR] COMPOSÉS BISPHÉNOL
  申请人：UNIV PENNSYLVANIA

  公开号：WO2019104153A1

  公开（公告）日：2019-05-31

  The present disclosure provides compounds of formula (I) or salts thereof, wherein R1- R10 and x are defined herein; compositions containing these compounds; methods of inhibiting, reducing, or ameliorating bacterial growth on a substrate using these compound; and products such as dental care products, soaps, antibacterial products, and plastics comprise one or more compounds described herein.

  本公开提供了式（I）的化合物或其盐，其中R1-R10和x在此处定义；含有这些化合物的组合物；使用这些化合物抑制、减少或改善基质上细菌生长的方法；以及包括本文描述的一个或多个化合物的产品，如口腔护理产品、肥皂、抗菌产品和塑料。
• Dodds et al., Proceedings of the Royal Society of London. Series B, Biological sciences, 1953, vol. 140, p. 470,478
  作者：Dodds et al.

  DOI：——

  日期：——
• BISPHENOL COMPOUNDS
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US20200375949A1

  公开（公告）日：2020-12-03

  The present disclosure provides compounds of formula (I) or salts thereof, wherein R 1 -R 10 and x are defined herein; compositions containing these compounds; methods of inhibiting, reducing, or ameliorating bacterial growth on a substrate using these compound; and products such as dental care products, soaps, antibacterial products, and plastics comprise one or more compounds described herein.
• A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism
  作者：Cristian Ochoa、Amy E. Solinski、Marcus Nowlan、Madeline M. Dekarske、William M. Wuest、Marisa C. Kozlowski

  DOI：10.1021/acsinfecdis.9b00190

  日期：2020.1.10

  Targeting Streptococcus mutans is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product honokiol. Herein, a structure activity relationship (SAR) study to ascertain structural motifs key to inhibition is outlined. Furthermore, mechanism studies show that bacterial membrane disruption is central to the bacterial growth inhibition. During this process, it was discovered that analog C2 demonstrated a 4-fold better therapeutic index compared to the commercially available antimicrobial cetylpyridinium chloride (CPC) making it a viable alternative for oral care.