4-(1-methylpropyl)-1,2-benzenediol | 1129-27-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1-methylpropyl)-1,2-benzenediol
• 英文别名: 4-(1-methylpropyl)benzene-1,2-diol；4-sec-butylcatechol；1,2-dihydroxy-4-sec.butylbenzene；4-(Butan-2-YL)benzene-1,2-diol；4-butan-2-ylbenzene-1,2-diol
• CAS: 1129-27-7
• 化学式: C₁₀H₁₄O₂
• 分子量: 166.22
• InChiKey: WGGXNHOXAQXOAQ-UHFFFAOYSA-N

物化性质

• 沸点：
  90 °C(Press: 4e-1 Torr)
• 密度：
  1.087±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3-二氯丙酮 、 4-(1-methylpropyl)-1,2-benzenediol 在 potassium carbonate 、 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 4.0h， 以49%的产率得到7-(1-methylpropyl)-2H-1,5-benzodioxepin-3(4H)-one
  参考文献：
  名称：

  具有海洋音符的气味域中的结构-活动关系

  摘要：

  我们合成或重新合成了大量2 H -1,5-benzodioxepin-3（4 H）-ones 9（方案1），4,5-dihydro-1-benzoxepin-3（2 H）-ones 10（方案3和4）和5,6,8,9-四氢-7 H-苯并环庚烯-7-酮11（方案5和6），因为基于海洋协议的香水嗅觉的先导化合物很好命名-known benzodioxepinone使Calone 1951年®（9B）。我们精心描述的每个合成的化合物的气味特征和讨论有关结构气味的关系（表1 - 3）。特别地，我们揭示了七元环的构象与这些化合物的活性之间的相关性（表4和图3）。我们还阐明了芳环上烷基取代基的位置和大小的影响。

  DOI：

  10.1002/hlca.200790126
• 作为产物：
  描述：

  4-丁烷-2-基-2-硝基苯酚 在 nitrophenol oxygenase 作用下， 以 phosphate buffer 为溶剂， 生成 4-(1-methylpropyl)-1,2-benzenediol
  参考文献：
  名称：

  Comparison of substituted 2-nitrophenol degradation by enzyme extracts and intact cells

  摘要：

  The first catabolic pathway enzyme, nitrophenol oxygenase, transforms o-nitrophenol (ONP) to catechol. Thirteen of 16 substituted nitrophenols tested were actively transformed by both enzyme preparations and intact cells yielding a wide range of K(m) (K(s)) and V(max). Individual chemicals in binary mixtures demonstrated competitive inhibition. Chemical and physical characteristics (electron withdrawal, size, and position of substitution on the 2-nitrophenol ring) affected degradation kinetics. The strongest correlations were between K(m) or V(max) values and electron withdrawal, though there was also evidence for effects relating to position and size of substitution on the aromatic ring. Kinetic parameters determined for enzyme preparations did not correlate to those determined for intact cells. Though enzyme reactivity ultimately determined whether a given chemical would be transformed, the transformation by intact cells was apparently affected by factors other than those directly impacting the initial catabolic enzyme.

  DOI：

  10.1021/es00051a018

文献信息

• Carbon Nanotubes as Activating Tyrosinase Supports for the Selective Synthesis of Catechols
  作者：Fabiana Subrizi、Marcello Crucianelli、Valentina Grossi、Maurizio Passacantando、Lorenzo Pesci、Raffaele Saladino

  DOI：10.1021/cs400856e

  日期：2014.3.7

  with respect to that of the native enzyme. These catalysts were used in the selective synthesis of catechols by oxidation of meta- and para-substituted phenols in an organic solvent (CH2Cl2) as the reaction medium. It is worth noting that immobilized tyrosinase was able to catalyze the oxidation of very hindered phenol derivatives that are slightly reactive with the native enzyme. The increased reactivity

  通过应用逐层原理，制备了一系列基于酪氨酸酶固定在多壁碳纳米管上的氧化还原催化剂。氧化的纳米管（OX-多壁碳纳米管）与聚（二烯丙基二甲基氯化铵）（PDDA）和酪氨酸酶，得到氧化型多壁碳纳米管处理/ PDDA /酪氨酸酶我。已经通过增加PDDA和酶的层数来制备催化剂II和III，而通过将酪氨酸酶与牛血清白蛋白（ox-MWCNTs / PDDA / BSA-酪氨酸酶）共同固定来获得IV。尝试共价结合酪氨酸酶提供了弱活性系统。基于简单的逐层原理的酶包衣提供了催化剂I–III，其活性范围从21单位/毫克（多层，II）到66单位/毫克（单层，I），最好的体系是催化剂IV（80单位/ mg）。通过扫描电子显微镜和原子力显微镜对新型催化剂进行了充分表征，显示出相对于天然酶而言增加的活性。这些催化剂在通过氧化儿茶酚的选择性合成中使用的元-和对位在有机溶剂中-取代的酚（CH 2氯2）作为反应介质。值得注意的是
• POSITIVE-TYPE RESIST COMPOSITION, METHOD FOR FORMING RESIST PATTERN, PHOTO-REACTIVE QUENCHER, AND POLYMERIC COMPOUND
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20160376233A1

  公开（公告）日：2016-12-29

  A positive-type resist composition which generates an acid upon exposure and whose solubility in an alkali developing solution increases under the action of an acid, the composition including a base material component whose solubility in an alkali developing solution increases under the action of an acid; and a compound represented by the following general formula (m0): Z 01 to Z 04 each independently represent a substituent having electron withdrawing properties, Rb 21 and Rb 22 each independently represent an alkyl group, an alicyclic hydrocarbon group which may have a substituent, or a hydroxyl group, Rb 1 represents an aryl group which may have a substituent, an alkyl group, or an alkenyl group, n1 and n2 represent an integer of 0 to 3, and X0 − represents an organic anion.

  一种正型抗蚀组合物，曝光后生成酸，其在碱性显影溶液中的溶解度在酸的作用下增加，该组合物包括一种基材组分，在酸的作用下在碱性显影溶液中的溶解度增加；以及由以下一般式（m0）表示的化合物：Z01至Z04分别独立表示具有电子吸引性的取代基，Rb21和Rb22分别独立表示烷基基团、可能具有取代基的脂环烃基团或羟基，Rb1表示可能具有取代基的芳基、烷基或烯基，n1和n2表示0至3的整数，X0−表示有机阴离子。
• ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE FILM, MASK BLANK PROVIDED WITH ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE FILM, PATTERN FORMING METHOD, METHOD FOR MANUFACTURING ELECTRONIC DEVICE, ELECTRONIC DEVICE, AND COMPOUND
  申请人：FUJIFILM Corporation

  公开号：US20160280675A1

  公开（公告）日：2016-09-29

  The actinic ray-sensitive or radiation-sensitive resin composition includes a crosslinking agent having a polarity converting group and an alkali-soluble resin, in which the polarity converting group is a group capable of decomposing by the action of an alkaline aqueous solution to generate a carboxylic acid or sulfonic acid on the side having a crosslinking group.

  感光树脂或辐射敏感树脂组合物包括具有极性转换基团和可溶于碱性树脂的交联剂，其中极性转换基团是一种能够通过碱性水溶液作用分解并在具有交联基团的侧面生成羧酸或磺酸的基团。
• POSITIVE RESIST COMPOSITION AND PATTERN FORMING METHOD USING THE SAME
  申请人：HIRANO Shuji

  公开号：US20080248419A1

  公开（公告）日：2008-10-09

  A positive resist composition, includes: (A) a resin that has a group having absorption at 248 nm at a main chain terminal of the resin (A), and a pattern forming method uses the composition.

  一种正性光刻胶组合物，包括：（A）一种具有在树脂（A）的主链端具有在248nm处吸收的基团的树脂，并且使用该组合物进行图案形成的方法。
• BIOMIMETIC COMPOUNDS AND SYNTHETIC METHODS THEREFOR
  申请人：Lee Bruce P.

  公开号：US20100197868A1

  公开（公告）日：2010-08-05

  Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical properties of DHPp, allowing it to be useful for different applications i.e. tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.

  本文介绍了用于制造含二羟基苯基衍生物（DHPD）或DHPp的聚合物化合物的合成方法，即通过DHPD改性的聚合物，具有所需的表面活性效果。 DHPp的聚合物骨架具有可定制的结构或性能特征，可以控制DHPp的物理特性，使其在不同的应用中有用，例如组织粘合剂或密封剂，促进粘附涂层和防污涂层。