divinyl octanedioate | 35873-11-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: divinyl octanedioate
• 英文别名: divinyl suberate；octanedioic acid divinyl ester；Divinyl suberat；Octanedioic acid,1,8-diethenyl ester；bis(ethenyl) octanedioate
• CAS: 35873-11-1
• 化学式: C₁₂H₁₈O₄
• 分子量: 226.273
• InChiKey: HZLCYFUZPYEUJL-UHFFFAOYSA-N

物化性质

• 沸点：
  296.3±23.0 °C(Predicted)
• 密度：
  1.011±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  divinyl octanedioate 、 methyl shikimate 在 lipase acrylic resin from Candida antarctica 作用下， 以 丙酮 为溶剂， 反应 14.0h， 以62.5%的产率得到
  参考文献：
  名称：

  sh草酸甲酯的可聚合衍生物的高度区域选择性酶促合成。

  摘要：

  描述了用于合成sh草酸甲酯的可聚合衍生物的酶促方法的区域可控选择性。南极假丝酵母的脂肪酶丙烯酸树脂（CAL-B）和Mucor miehei的固定化脂肪酶（MML）对sh草酸甲酯的仲羟基具有较高的区域选择性，呈现出三个具有相似反应性的羟基。通过MML在丙酮中的催化促进了高产率的5-O-酰基甲基sh草酸酯衍生物的一步合成，而在丙酮中使用CAL-B提供了4-O-酰基甲基sh草酸酯衍生物。所获得的sh草酸甲酯衍生物系列将是sh草酸的潜在有用类似物的重要单体。

  DOI：

  10.1016/j.bmcl.2007.10.064
• 作为产物：
  描述：

  辛二酸 、 丙酸乙烯酯 在 硫酸 、 mercury(II) diacetate 作用下， 生成 divinyl octanedioate
  参考文献：
  名称：

  Synthesis of poly (glycerol-co-dioate-co-butanedioate-co-xanthorrhizol) ester and a study of chain length effect on pendant group loading

  摘要：

  Natural R-(-)-xanthorrhizol possess a number of therapeutic activities including anti-cancer. The pharmacokinetic properties of that poorly aqueous soluble compound could be improved by incorporating it into polymeric materials. Glycerol can produce a functionalized polymer through a polycondensation process. Enzymatic polycondensation of glycerol and divinylesters was studied and xanthorrhizol was covalently loaded via a butanedioate linker to the polymer backbone. It was observed that xanthorrhizol loading to the polymer backbone increases with the increasing of the chain length of a dioate moiety. Enzyme-mediated xanthorrhizol release from a polymer backbone shows that the polymeric prodrug is able to release xanthorrhizol in a sustained manner. Therefore, the approach described here might be valuable for controlled loading and release of such phenolic sesquiterpenes from the polymeric prodrug. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcatb.2012.05.022

文献信息

• COMPOSITION THAT CAN BE CURED BY POLYMERISATION FOR THE PRODUCTION OF BIODEGRADABLE, BIOCOMPATIBLE, CROSS-LINKABLE POLYMERS ON THE BASIS OF POLYVINYL ALCOHOL
  申请人：Liska Robert

  公开号：US20100303804A1

  公开（公告）日：2010-12-02

  The present invention relates to a polymerization-curable composition for the preparation of biodegradable, biocompatible, cross-linked polymers on the basis of polyvinyl alcohol comprising: 5 to 100% by weight of (a) vinyl ester monomer(s) of one of the general formulas (I) to (III): wherein X is oxygen, sulfur, nitrogen, or phosphorus; n is 1 to 1000, at least 20% of the n being ≧2; the R 1 are selected from hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups having 1 to 30 carbon atoms, which optionally have heteroatoms and are optionally substituted with one or more substituents selected from —OH, —COON, —CN, —CHO, and ═O, and n-valent radicals of biodegradable, biocompatible oligomers and polymers; m is an integer from 1 to 5; the R 2 are selected from hydrogen, —OH, ═O, and the options listed for R 1 ; and the R 3 are selected from hydrogen, —OH, and the options listed for R 1 ; 0 to 50% by weight of ethylenically unsaturated co-monomers; 0 to 10% by weight of (a) polymerization initiator(s); and 0 to 95% by weight of solvent(s).

  本发明涉及一种用于制备基于聚乙烯醇的可生物降解、生物相容、交联聚合物的聚合固化组合物，包括：按重量计5至100%的(a)乙烯酸酯单体，其具有下列通式(I)至(III)之一： 其中X为氧、硫、氮或磷；n为1至1000，n的至少20%为≧2；R 1 选自氢；直链、支链或环状、饱和或不饱和、含有1至30个碳原子的n价碳氢基团，该基团可选地具有杂原子，并可选地被选自—OH、—COON、—CN、—CHO和═O的一个或多个取代基以及生物降解、生物相容寡聚物和聚合物的n价基团取代；m为1至5的整数；R 2 选自氢、—OH、═O以及R 1 中列出的选项；R 3 选自氢、—OH以及R 1 中列出的选项；按重量计0至50%的乙烯基不饱和共聚单体；按重量计0至10%的(a)聚合引发剂；按重量计0至95%的溶剂。
• [EN] PROCESS FOR PREPARING RAPAMYCIN 42-ESTERS AND FK-506 32-ESTERS WITH DICARBOXYLIC ACID, PRECURSORS FOR RAPAMYCIN CONJUGATES AND ANTIBODIES<br/>[FR] PROCEDE D'ELABORATION DE 42-ESTERS DE RAPAMYCINE ET DE 32-ESTERS DE FK-506 AVEC DE L'ACIDE DICARBOXYLIQUE, PRECURSEURS POUR CONJUGUES DE RAPAMYCINE ET ANTICORPS VIS-A-VIS DE LA RAPAMYCINE
  申请人：WYETH CORP

  公开号：WO2005105812A1

  公开（公告）日：2005-11-10

  Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional activated ester of dicarboxylic acid with a lipase.

  本文描述了合成具有区域特异性的42-半酯化雷帕霉素和32-酯化FK506的方法，该方法涉及使用脂肪酶催化雷帕霉素或FK-506与二羧酸酐或双官能团活性二羧酸酯之间的反应。
• Medical Resin Composition, Process For Producing Resin Composition and Process For Producing Molded Article
  申请人：Tanaka Jiro

  公开号：US20080200630A1

  公开（公告）日：2008-08-21

  A medical resin composition is produced by mixing a powder of a polymer (A) comprising repeating units having an ester group and a liquid of a vinyl ester monomer (B) having 6 or more carbon atoms to increase a viscosity and, according to demand, further performing a polymerization reaction. The thus produced resin composition inhibits leaching of irritative substances, reduces any adverse effects on the human body by endocrine disruptors, etc. and can be prepared with high operational efficiency. The resin composition is suitably used as a dental resin composition such as a tissue conditioner, a functional impression material, a lining material, a denture base material or a mouth piece material.

  一种医用树脂组合物的制备方法，包括将含有酯基重复单元的聚合物(A)粉末和含有6个或更多碳原子的乙烯酸酯单体(B)液体混合以增加粘度，并根据需要进一步进行聚合反应。由此制得的树脂组合物抑制刺激性物质的渗出，减少内分泌干扰物对人体的不良影响等，并且可以高效制备。该树脂组合物适用于牙科树脂组合物，例如组织调整剂、功能印模材料、填补材料、义齿基材料或口腔器材材料。
• Process for producing resin composition and process for producing molded article
  申请人：Tanaka Jiro

  公开号：US20100184921A1

  公开（公告）日：2010-07-22

  A medical resin composition is produced by mixing a powder of a polymer (A) comprising repeating units having an ester group and a liquid of a vinyl ester monomer (B) having 6 or more carbon atoms to increase a viscosity and, according to demand, further performing a polymerization reaction. The thus produced resin composition inhibits leaching of irritative substances, reduces any adverse effects on the human body by endocrine disruptors, etc. and can be prepared with high operational efficiency. The resin composition is suitably used as a dental resin composition such as a tissue conditioner, a functional impression material, a lining material, a denture base material or a mouth piece material.

  一种医用树脂组合物是通过混合聚合物(A)粉末和含有6个或更多碳原子的乙烯酸酯单体(B)的液体来增加粘度，并根据需要进一步进行聚合反应制备的。因此制得的树脂组合物抑制了刺激性物质的渗出，减少了内分泌干扰物对人体的不良影响等，并且可以高效制备。该树脂组合物适用于牙科树脂组合物，例如组织调节剂、功能印象材料、衬里材料、假牙基材料或口腔器材材料。
• Ultraviolet curable resin composition with excellent adhesion
  申请人：Ajinomoto Co., Inc.

  公开号：EP0552795A1

  公开（公告）日：1993-07-28

  An ultraviolet curable resin composition characterized by incorporating (a) 100 parts by weight of a resin composition which undergoes radical polymerization under ultraviolet light to form a cured substance, and (b) 0.5 - 20 parts by weight of a carboxylic acid vinyl ester compound having at least 2 ethylenically unsaturated double bonds. Adhesion to plastic substrates was improved without deterioration of properties of the starting resin.

  一种可紫外线固化的树脂组合物，其特征在于：(a) 100 重量份的树脂组合物，该树脂组合物在紫外线下发生自由基聚合反应，形成固化物；(b) 0.5 - 20 重量份的羧酸乙烯基酯化合物，该化合物至少具有 2 个乙烯基不饱和双键。 与塑料基材的粘附性得到了改善，而起始树脂的性能没有下降。