(2,5-Dioxopyrrolidin-1-yl) 3-[(2,4-dimethoxyphenyl)-hydroxy-perylen-3-ylmethyl]benzoate | 292624-80-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (2,5-Dioxopyrrolidin-1-yl) 3-[(2,4-dimethoxyphenyl)-hydroxy-perylen-3-ylmethyl]benzoate
• CAS: 292624-80-7
• 化学式: C₄₀H₂₉NO₇
• 分子量: 635.673
• InChiKey: HIMIKKNZXIFKBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  48
• 可旋转键数：
  8
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (2,5-Dioxopyrrolidin-1-yl) 3-[(2,4-dimethoxyphenyl)-hydroxy-perylen-3-ylmethyl]benzoate 以 二氯甲烷 为溶剂， 生成 N-[3-[2-[2-[3-[[3-[(2,4-dimethoxyphenyl)-hydroxy-perylen-3-ylmethyl]benzoyl]amino]propoxy]ethoxy]ethoxy]propyl]-3-[(2,4-dimethoxyphenyl)-hydroxy-pyren-1-ylmethyl]benzamide
  参考文献：
  名称：

  Tritylisation of pyrene, perylene and coronene: a new family of switchable fluorescent labels

  摘要：

  The synthesis of novel fluorescent labels based on pyrene, perylene and coronene is described. Due to the trityl-type structure, their fluorescence may be reversibly switched on and off by changing the pH. This property can be used to expand the palette of fluorophores available for multicolour DNA detection on DNA chips. Some FRET and surface chemistry applications are also demonstrated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00737-1
• 作为产物：
  描述：

  2,4-二甲氧基苯甲酰氯 在 三氯化铝 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 氯苯 为溶剂， 反应 51.0h， 生成 (2,5-Dioxopyrrolidin-1-yl) 3-[(2,4-dimethoxyphenyl)-hydroxy-perylen-3-ylmethyl]benzoate
  参考文献：
  名称：

  Tritylisation of pyrene, perylene and coronene: a new family of switchable fluorescent labels

  摘要：

  The synthesis of novel fluorescent labels based on pyrene, perylene and coronene is described. Due to the trityl-type structure, their fluorescence may be reversibly switched on and off by changing the pH. This property can be used to expand the palette of fluorophores available for multicolour DNA detection on DNA chips. Some FRET and surface chemistry applications are also demonstrated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00737-1

文献信息

• Trityl derivatives for enhancing mass spectrometry
  申请人：SHCHEPINOV Mikhail Sergeevich

  公开号：US20080248584A1

  公开（公告）日：2008-10-09

  Compounds of formula (IIa): are provided where: X is a group capable of being cleaved from the α-carbon atom to form an ion of formula (I′) C is a carbon atom bearing a single positive charge or a single negative charge; The invention further provides compounds of formula (IIb): where: X is a counter-ion to C . The compounds of formula (IIa) and (IIb) may form ions of formula (I′) by either cleaving the C—X bond between X and the α-carbon atoms in the case of the compounds of formula (IIa) or dissociating X in the case of compounds of formula (IIb).
• Tritylisation of pyrene, perylene and coronene: a new family of switchable fluorescent labels
  作者：Mikhail S Shchepinov、Vladimir A Korshun、Ryan D Egeland、Edwin M Southern

  DOI：10.1016/s0040-4039(00)00737-1

  日期：2000.6

  The synthesis of novel fluorescent labels based on pyrene, perylene and coronene is described. Due to the trityl-type structure, their fluorescence may be reversibly switched on and off by changing the pH. This property can be used to expand the palette of fluorophores available for multicolour DNA detection on DNA chips. Some FRET and surface chemistry applications are also demonstrated. (C) 2000 Elsevier Science Ltd. All rights reserved.