6-phenoxyhexan-1-ol | 16654-54-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-phenoxyhexan-1-ol
• 英文别名: 6-(phenoxy)-1-hexanol；1-Hexanol, 6-phenoxy-
• CAS: 16654-54-9
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: KGAAHYOKTFZJFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-phenoxyhexan-1-ol 在 氢碘酸 作用下， 生成 ((6-iodohexyl)oxy)benzene
  参考文献：
  名称：

  v. Braun; Deutsch; Schmatloch, Chemische Berichte, 1912, vol. 45, p. 1255

  摘要：

  DOI：
• 作为产物：
  描述：

  6-phenoxyhexanoic acid 在 lithium aluminium tetrahydride 作用下， 生成 6-phenoxyhexan-1-ol
  参考文献：
  名称：

  Mass spectrometry in structural and stereochemical problems. CLV. Electron impact induced fragmentations and rearrangements of some trimethylsilyl ethers of aliphatic glycols, and related compounds

  摘要：

  DOI：

  10.1021/jo01270a022

文献信息

• Method of treating lipidemia with aryloxyalkylaminobenzoic acids and
  申请人：American Cyanamid Company

  公开号：US04182776A1

  公开（公告）日：1980-01-08

  Aryloxyalkylaminobenzoic acids and esters as hypolipemic compounds.

  芳氧烷基氨基苯甲酸和酯作为降脂化合物。
• Copper-Catalyzed Reduction of Alkyl Triflates and Iodides: An Efficient Method for the Deoxygenation of Primary and Secondary Alcohols
  作者：Hester Dang、Nick Cox、Gojko Lalic

  DOI：10.1002/anie.201307697

  日期：2014.1.13

  We describe an effective method for catalytic reduction of 1° alkyl sulfonates, and 1° and 2° iodides in the presence of a wide range of functional groups. This Cu‐catalyzed reaction provides a means for the effective deoxygenation of alcohols, as demonstrated by the highly selective reduction of 1° alcohols using a triflation/reduction sequence. A preliminary study of the reaction mechanism suggests

  我们描述了一种在多种官能团存在下催化还原1°烷基磺酸盐以及1°和2°碘化物的有效方法。铜催化的反应为醇的有效脱氧提供了一种手段，正如使用三氟甲磺酸化/还原序列对1°醇的高度选择性还原所证明的那样。对反应机理的初步研究表明，还原反应不涉及自由基中间体。
• NHC–copper hydrides as chemoselective reducing agents: catalytic reduction of alkynes, alkyl triflates, and alkyl halides
  作者：Nick Cox、Hester Dang、Aaron M. Whittaker、Gojko Lalic

  DOI：10.1016/j.tet.2014.04.004

  日期：2014.7

  as well as the NHC–copper-catalyzed reduction of primary alkyl triflates and primary and secondary alkyl iodides and bromides are described. The high chemoselectivity demonstrated in these examples illustrates the mild nature of copper hydride complexes as reducing agents, which have applications in synthetic chemistry beyond their traditional role in the reduction of activated alkenes and carbonyl compounds

  介绍了NHC-铜催化的末端炔和内部炔的Z选择性半还原，以及NHC-铜催化的伯烷基三氟甲磺酸酯，伯和仲烷基碘和溴化物的还原。这些实施例中证明的高化学选择性说明了氢化铜络合物作为还原剂的温和性质，其在合成化学中的应用超出了它们在还原活化烯烃和羰基化合物方面的传统作用。
• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE
  申请人：Arvinas, Inc.

  公开号：US20180177750A1

  公开（公告）日：2018-06-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of enhancer of zeste homolog 2 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为增强子锁定同源2的调节剂而发挥作用。具体而言，本公开涉及包含一端为Von Hippel-Lindau、cereblon、凋亡抑制蛋白或鼠双分子同源2配体的双功能化合物，该配体与相应的E3泛素连接酶结合，另一端含有结合目标蛋白的基团，使目标蛋白靠近泛素连接酶以实现目标蛋白的降解（和抑制）。本公开展示了与目标蛋白的降解/抑制相关的广泛药理活性范围。本公开的化合物和组合物用于治疗或预防由目标蛋白聚集或积累导致的疾病或紊乱。
• Supramolecular phenoxy-alkyl maleate-based hydrogels and their enzyme/pH-responsive curcumin release
  作者：Bijari Anil Kumar、Rati Ranjan Nayak

  DOI：10.1039/c8nj05796f

  日期：——

  Low-molecular-weight gelators that self-assemble via non-covalent interactions have been attracting significant attention due to their good biocompatibility, low toxicity, inherent biodegradability as well as their convenience of design. Enzymatically digestible and pH-sensitive hydrogels play an important role in controlled drug delivery applications. In the present study, we synthesized four simple

  通过非共价相互作用自组装的低分子量胶凝剂由于其良好的生物相容性，低毒性，固有的生物降解性以及设计的方便性而受到了广泛的关注。酶可消化且对pH敏感的水凝胶在受控药物递送应用中起着重要作用。在本研究中，我们合成了四个简单的具有不同疏水链长度（C 6 –C 12）的马来酸苯氧基烷基酯两亲物。在磷酸盐缓冲液中检测了四种两亲物的胶凝能力。其中，C 10和C 12的马来酸酯链长分别在最小胶凝浓度（MGC）为1.6和1.3％w / v时显示出胶凝能力。这些水凝胶化剂显示出可以捕获水分子的牢固的三维交联网络。使用差示扫描量热法（DSC），扫描电子显微镜，密度泛函理论（DFT）计算，X射线衍射和流变学研究对获得的超分子水凝胶进行了全面表征。更重要的是，姜黄素（一种疏水性药物）被封装（1％w / v）到凝胶核中，其随后的释放是通过脂酶（生物刺激）诱导的从凝胶到溶胶的转变而实现的。另外，载有药物的水凝胶表现出p