quercitrin | 22324-77-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: quercitrin
• 英文别名: quercetin 3-O-rhamnopyranoside；quercetin 3-O-rhamnoside；quercetin-3-O-rhamnoside；quercetin 3-rhamnoside；quercetin-3-rhamnoside；guercitrin；2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
• CAS: 22324-77-2
• 化学式: C₂₁H₂₀O₁₁
• 分子量: 448.383
• InChiKey: OXGUCUVFOIWWQJ-GPTQEAJUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  186
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  quercitrin 在 盐酸 、 水 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 5-氯-2-氟三氟甲苯 、 槲皮素
  参考文献：
  名称：

  Maesa lanceolata 叶的三萜皂苷

  摘要：

  对 Maesa lanceolata 叶含水 MeOH 提取物的化学研究导致分离出八种新的三萜糖苷，鉴定为 16-oxo-28-hydroxyolean-12-ene 3-O-β-glupyranosyl-(1''→6')-β -吡喃葡萄糖苷 1, 16α, 28-dihydroxyolean-12-ene 3 -O-β-((6''-O-galloylglupyranosyl-(1''→2'))(β-glupyranosyl-(1'''→6) '))-β-吡喃葡萄糖苷 2, 16α, 22α, 28-trihydroxyolean-12-ene 3-O-(β-glupyranosyl-(1''→2')) (α-rhamnopyranosyl-(1'''→6) ')-β-吡喃葡萄糖苷 3, 22α-乙酰基-16α-hydroxyolean-12-en-28-al 3-O-(α-rhamnop

  DOI：

  10.3998/ark.5550190.0012.214

文献信息

• Pyrone analogs for therapeutic treatment
  申请人：Robbins Wendye

  公开号：US20100189653A1

  公开（公告）日：2010-07-29

  Methods are described for the treatment and prevention of metabolic disorders or other diseases by administering a pyrone analog or a derivative thereof. Methods are also described for the treatment and prevention of metabolic disorders and other diseases by administering a pyrone analog, or a derivative thereof, in combination with one or more additional agents such as, for example, lipid lowering agents or glucose lowering agents. Methods are described for the modulation of lipid transporter activity to increase the efflux of lipid from a physiological compartment into an external environment. Methods disclosed herein may be used to assess treatment or prevention of a metabolic disorder following administration of a pyrone analog or a derivative thereof.

  本文介绍了使用吡喃类似物或其衍生物治疗和预防代谢性疾病或其他疾病的方法。本文还介绍了使用吡喃类似物或其衍生物与一个或多个其他药剂（例如，降脂药或降糖药）联合使用治疗和预防代谢性疾病和其他疾病的方法。本文还介绍了调节脂质转运蛋白活性以增加生理隔室中脂质向外部环境排出的方法。本文所披露的方法可用于评估使用吡喃类似物或其衍生物后治疗或预防代谢性疾病的效果。
• PHOSPHORYLATED AND PHOSPHONATED PYRONE ANALOGS FOR THERAPEUTIC TREATMENT
  申请人：Lee May Dean-Ming

  公开号：US20100297020A1

  公开（公告）日：2010-11-25

  Methods are described for the treatment and prevention of metabolic disorders or other diseases by administering a pyrone analog or a derivative thereof. Methods are also described for the treatment and prevention of metabolic disorders and other diseases by administering a pyrone analog, or a derivative thereof, in combination with one or more additional agents such as, for example, lipid lowering agents or glucose lowering agents. Methods are described for the modulation of lipid transporter activity to increase the efflux of lipid from a physiological compartment into an external environment. Methods disclosed herein may be used to assess treatment or prevention of a metabolic disorder following administration of a pyrone analog or a derivative thereof.

  本文描述了通过给予吡喃类似物或其衍生物的方法来治疗和预防代谢性疾病或其他疾病。还描述了通过给予吡喃类似物或其衍生物与一个或多个额外的药物如降脂药或降糖药组合的方法来治疗和预防代谢性疾病和其他疾病。本文还描述了调节脂质转运蛋白活性以增加生理区域中脂质向外部环境的外流的方法。本文所披露的方法可用于评估在给予吡喃类似物或其衍生物后治疗或预防代谢性疾病的效果。
• Schwer lösliche Salze von Aminoglykosidantibiotika
  申请人：MERCK PATENT GmbH

  公开号：EP0065123A1

  公开（公告）日：1982-11-24

  Neue schwer lösliche Flavanoidphosphate von Aminoglykosidantibiotika, insbesondere Hesperidinphosphate wie Gentamycin-hesperidinphosphat, bewirken eine langsame Freisetzung dieser Antibiotika.

  氨基糖苷类抗生素的新型难溶性黄酮类磷酸盐，特别是橙皮甙磷酸盐（如庆大霉素橙皮甙磷酸盐），可使这些抗生素缓慢释放。
• New extracts of ginkgo biloba and their methods of preparation
  申请人：INDENA S.p.A.

  公开号：EP0360556A1

  公开（公告）日：1990-03-28

  A process is provided for producing a purified extract from Ginkgo biloba leaves by solvent extraction with selected solvents. In the process, a crude or partially purified extract is subjected to solvent extraction with a solvent comprising a C₆₋₈ aromatic hydrocarbon and a C₃₋₆ lower alkanol. Pharmaceutical compositions comprising dimeric flavones and/or polyphenols are also described.

  提供了一种用选定溶剂进行溶剂萃取从银杏叶中提取纯化提取物的工艺。在该工艺中，粗提取物或部分纯化提取物用一种溶剂进行溶剂萃取，该溶剂包括一种 C₆₋₈芳香烃和一种 C₃₋₆低级烷醇。还描述了包含二聚黄酮和/或多酚的药物组合物。
• Tire with rubber containing flavone
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP1391327A1

  公开（公告）日：2004-02-25

  The invention relates to a rubber composition and a pneumatic tire having a component comprising a rubber containing the reaction product of a flavone and a methylene donor.

  本发明涉及一种橡胶组合物和充气轮胎，其成分包括含有黄酮和亚甲基供体反应产物的橡胶。