2-chloro-3-hydroxypropionic acid | 134267-57-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 2-chloro-3-hydroxypropionic acid
• 英文别名: 2-chloro-3-hydroxypropanoic acid
• CAS: 134267-57-5
• 化学式: C₃H₅ClO₃
• 分子量: 124.524
• InChiKey: GAHMZBZGINHHJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-chloro-3-hydroxypropionic acid 在 硫酸 作用下， 生成 2-氯丙烯酸
  参考文献：
  名称：

  Koelsch, Journal of the American Chemical Society, 1930, vol. 52, p. 3365

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-2,3-二羟基丙酸 在 盐酸 作用下， 生成 2-chloro-3-hydroxypropionic acid
  参考文献：
  名称：

  Michael, Journal fur praktische Chemie (Leipzig 1954), 1899, vol. <2> 60, p. 423

  摘要：

  DOI：

文献信息

• POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS
  申请人：He Wei

  公开号：US20160200730A1

  公开（公告）日：2016-07-14

  Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.

  本文描述了一种新型的多氟取代吡唑嘧啶化合物或其盐。这些化合物是布鲁顿酪氨酸激酶（BTK）抑制剂。这些化合物可能具有更好的BTK抑制选择性和药代动力学特性。本文披露了这些化合物的合成方法。本文还披露了多氟取代苯甲酮和取代苯氧基苯的新型合成方法。还披露了包括上述BTK抑制剂的药物组合物。本发明还涉及包含上述化合物作为活性成分的药物配方。本发明还包括通过给予BTK抑制剂及其配方来治疗和抑制自身免疫疾病、过敏性疾病、炎症性疾病和癌症的治疗方法。
• SYNTHESIS OF INIMERS AND HYPERBRANCHED POLYMERS
  申请人：Pugh Coleen R.

  公开号：US20110046334A1

  公开（公告）日：2011-02-24

  An inimer, and process for making same, having the following formula: wherein X=halogen, nitroxide, thioester; R═H or CH 3 ; and R′=aliphatic, non-aliphatic, linear or branched, mesogenic, non mesogenic, chiral, achiral, hydrocarbon, non-hydrocarbon, selected from fluorocarbon, oligo(oxyethylene) and siloxane substituents, alkyl, aryl, mesogenic group, non-mesogenic group, aliphatic, non-aliphatic, siloxane , perfluoroalkyl, perfluoroaryl, or other fluorocarbon group, and polymers, and the process of making them, from the inimer.

  一种含有以下配方的Inimer及其制备方法： 其中X=卤素、亚硝基、硫酯；R=H或CH3；R′=脂肪族、非脂肪族、直链或支链、向列型、非向列型、手性、非手性、碳氢化合物、非碳氢化合物，选自氟碳、寡聚（氧乙烯）和硅氧烷取代基、烷基、芳基、向列基团、非向列基团、脂肪族、非脂肪族、硅氧烷、全氟烷基、全氟芳基或其他氟碳基团、以及聚合物，以及从Inimer制备它们的方法。
• Synthesis of inimers and hyperbranched polymers
  申请人：Pugh Coleen R.

  公开号：US08524942B2

  公开（公告）日：2013-09-03

  An inimer, and process for making same, having the following formula: wherein X=halogen, nitroxide, thioester; R═H or CH3; and R′=aliphatic, non-aliphatic, linear or branched, mesogenic, non mesogenic, chiral, achiral, hydrocarbon, non-hydrocarbon, selected from fluorocarbon, oligo(oxyethylene) and siloxane substituents, alkyl, aryl, mesogenic group, non-mesogenic group, aliphatic, non-aliphatic, siloxane, perfluoroalkyl, perfluoroaryl, or other fluorocarbon group, and polymers, and the process of making them, from the inimer.

  一种含有以下配方的inimer及其制备方法： 其中X=卤素、亚硝基、硫酯；R=H或CH3；R′=脂肪族、非脂肪族、直链或支链、向列型、非向列型、手性、非手性、碳氢化合物、非碳氢化合物，选自氟碳、寡聚（氧乙烯）和硅氧烷取代基、烷基、芳基、向列基团、非向列基团、脂肪族、非脂肪族、硅氧烷、全氟烷基、全氟芳基或其他氟碳基团、以及聚合物，以及从inimer制备它们的方法。
• Synthesis of Hyperbranched Polyacrylates by a Chloroinimer Approach
  作者：Coleen Pugh、Anirudha Singh、Reichel Samuel、Karla M. Bernal Ramos

  DOI：10.1021/ma100416p

  日期：2010.6.22

  (2-Chloro-2-alkoxycarbonyl)ethyl acrylates with methyl, dodecyl, perfluoroalkyl, siloxane, oligooxyethylene, and mesogenic ester substituents were synthesized as inimers for self-condensing vinyl polymerization (SCVP) to produce hyperbranched polyacrylates. The inimers were polymerized by atom transfer radical polymerization under a variety of conditions to produce soluble polymers with broad polydispersities (up to PDI = 5.24) characteristic of hyperbranched polymers, although the isolated polymers had narrower polydispersities. The molecular weight distribution was followed as a function of time and inimer conversion for the polymerization of the mesogenic inimer. The first-order inimer conversion was linear with time. The buildup of a hyperbranched structure during the SCVP was confirmed by comparison of the error in the GPC(PSt)-determined molecular weights of the mesogenic polymer with those of the corresponding linear, three-arm star, and comb architectures.

  该研究通过开发新型Inimers（一种具有不同取代基的改性丙烯酸酯单体），成功实现了自缩合乙烯聚合（SCVP），制备了一系列超支化聚丙烯酸酯。这些Inimers具有多种功能化取代基，包括甲基、十二烷基、全氟烷基、硅氧烷、寡聚氧乙烯以及介晶取代基。研究采用了原子转移自由基聚合（ATRP）技术，在不同条件下进行聚合，成功制备了具有广泛分子量分布（最高PDI=5.24）的可溶性超支化聚合物，尽管分离出的聚合物分子量分布较窄。通过对具有介晶Inimer的聚合过程进行分析，发现Inimer的转化率与时间呈线性关系，这表明在SCVP过程中形成了明确的支化结构增长特性。通过对比介晶聚合物与对应线性、三臂星型以及梳状结构聚合物在凝胶渗透色谱（GPC，使用聚苯乙烯为标样）测定下的分子量误差，进一步证实了超支化结构的形成。
• Manufacture of hydroxy acids
  申请人：DISTILLERS CO YEAST LTD

  公开号：US02411700A1

  公开（公告）日：1946-11-26